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Journal of Cell Science, Vol 114, Issue 8 1439-1445, Copyright © 2001 by Company of Biologists

JOURNAL ARTICLES

Phosphoinositide 3-kinase signalling pathways

DA Cantrell
Lymphocyte Activation Laboratory, Imperial Cancer Research Fund, London, WC2A 3PX, UK. d.cantrell@icrf.icnet.uk

Phosphoinositide 3-kinases (PI3Ks) phosphorylate the 3'-OH position of the inositol ring of inositol phospholipids, producing three lipid products: PtdIns(3)P, PtdIns(3,4)P(2) and PtdIns(3,4,5)P(3). These lipids bind to the pleckstrin homology (PH) domains of proteins and control the activity and subcellular localisation of a diverse array of signal transduction molecules. Three major classes of signalling molecule are regulated by binding of D-3 phosphoinositides to PH domains: guanine-nucleotide-exchange proteins for &Rgr; family GTPases, the TEC family tyrosine kinases such as BTK and ITK in B and T lymphocytes, respectively, and the AGC superfamily of serine/threonine protein kinases. These molecules are activated by a variety of extracellular stimuli and have been implicated in a wide range of cellular processes, including cell cycle progression, cell growth, cell motility, cell adhesion and cell survival.
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Oxidized LDL-Induced Smooth Muscle Cell Proliferation Involves the EGF Receptor/PI-3 Kinase/Akt and the Sphingolipid Signaling Pathways
Arterioscler Thromb Vasc Biol, December 1, 2002; 22(12): 1990 - 1995.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
J. Kwang Yoo, J. Ho Cho, S. Woo Lee, and Y. Chul Sung
IL-12 Provides Proliferation and Survival Signals to Murine CD4+ T Cells Through Phosphatidylinositol 3-Kinase/Akt Signaling Pathway
J. Immunol., October 1, 2002; 169(7): 3637 - 3643.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
F. Berditchevski, E. Odintsova, S. Sawada, and E. Gilbert
Expression of the Palmitoylation-deficient CD151 Weakens the Association of alpha 3beta 1 Integrin with the Tetraspanin-enriched Microdomains and Affects Integrin-dependent Signaling
J. Biol. Chem., September 27, 2002; 277(40): 36991 - 37000.
[Abstract] [Full Text] [PDF]

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 J. Virol.Home page
Y. He, H. Nakao, S.-L. Tan, S. J. Polyak, P. Neddermann, S. Vijaysri, B. L. Jacobs, and M. G. Katze
Subversion of Cell Signaling Pathways by Hepatitis C Virus Nonstructural 5A Protein via Interaction with Grb2 and P85 Phosphatidylinositol 3-Kinase
J. Virol., September 15, 2002; 76(18): 9207 - 9217.
[Abstract] [Full Text] [PDF]

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 J. Neurophysiol.Home page
L. Lhuillier and S. E. Dryer
Developmental Regulation of Neuronal KCa Channels by TGFbeta 1: An Essential Role for PI3 Kinase Signaling and Membrane Insertion
J Neurophysiol, August 1, 2002; 88(2): 954 - 964.
[Abstract] [Full Text] [PDF]

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 Mol. Biol. CellHome page
L. E. Lindberg, S. Hedjazifar, and D. Baeckstrom
c-erbB2-induced Disruption of Matrix Adhesion and Morphogenesis Reveals a Novel Role for Protein Kinase B as a Negative Regulator of alpha 2beta 1 Integrin Function
Mol. Biol. Cell, August 1, 2002; 13(8): 2894 - 2908.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
N. A. Khan, Y. Wang, K. J. Kim, J. W. Chung, C. A. Wass, and K. S. Kim
Cytotoxic Necrotizing Factor-1 Contributes to Escherichia coli K1 Invasion of the Central Nervous System
J. Biol. Chem., May 3, 2002; 277(18): 15607 - 15612.
[Abstract] [Full Text] [PDF]

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 Cancer Res.Home page
H. Yamaguchi, H. Miki, and T. Takenawa
Neural Wiskott-Aldrich Syndrome Protein Is Involved in Hepatocyte Growth Factor-induced Migration, Invasion, and Tubulogenesis of Epithelial Cells
Cancer Res., May 1, 2002; 62(9): 2503 - 2509.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
K. L. Himmel, F. Bi, H. Shen, N. A. Jenkins, N. G. Copeland, Y. Zheng, and D. A. Largaespada
Activation of Clg, a Novel Dbl Family Guanine Nucleotide Exchange Factor Gene, by Proviral Insertion at Evi24, a Common Integration Site in B Cell and Myeloid Leukemias
J. Biol. Chem., April 12, 2002; 277(16): 13463 - 13472.
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 Proc. Natl. Acad. Sci. USAHome page
M. Ishii, A. Inanobe, and Y. Kurachi
PIP3 inhibition of RGS protein and its reversal by Ca2+/calmodulin mediate voltage-dependent control of the G protein cycle in a cardiac K+ channel
PNAS, April 2, 2002; 99(7): 4325 - 4330.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
J. Huang and C. D. Kontos
PTEN Modulates Vascular Endothelial Growth Factor-Mediated Signaling and Angiogenic Effects
J. Biol. Chem., March 22, 2002; 277(13): 10760 - 10766.
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 J. Cell Sci.Home page
M. A. Lawlor and D. R. Alessi
PKB/Akt: a key mediator of cell proliferation, survival and insulin responses?
J. Cell Sci., March 10, 2002; 114(16): 2903 - 2910.
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 J. Biol. Chem.Home page
E. M. Kovacs, R. G. Ali, A. J. McCormack, and A. S. Yap
E-cadherin Homophilic Ligation Directly Signals through Rac and Phosphatidylinositol 3-Kinase to Regulate Adhesive Contacts
J. Biol. Chem., February 15, 2002; 277(8): 6708 - 6718.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
M. Ishii, A. Inanobe, and Y. Kurachi
PIP3 inhibition of RGS protein and its reversal by Ca2+/calmodulin mediate voltage-dependent control of the G protein cycle in a cardiac K+ channel
PNAS, April 2, 2002; 99(7): 4325 - 4330.
[Abstract] [Full Text] [PDF]

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 Mol. Biol. CellHome page
M. Diakonova, G. Bokoch, and J. A. Swanson
Dynamics of Cytoskeletal Proteins during Fcgamma Receptor-mediated Phagocytosis in Macrophages
Mol. Biol. Cell, February 1, 2002; 13(2): 402 - 411.
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