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Journal of Cell Science, Vol 114, Issue 8 1439-1445, Copyright © 2001 by Company of Biologists

JOURNAL ARTICLES

Phosphoinositide 3-kinase signalling pathways

DA Cantrell
Lymphocyte Activation Laboratory, Imperial Cancer Research Fund, London, WC2A 3PX, UK. d.cantrell@icrf.icnet.uk

Phosphoinositide 3-kinases (PI3Ks) phosphorylate the 3'-OH position of the inositol ring of inositol phospholipids, producing three lipid products: PtdIns(3)P, PtdIns(3,4)P(2) and PtdIns(3,4,5)P(3). These lipids bind to the pleckstrin homology (PH) domains of proteins and control the activity and subcellular localisation of a diverse array of signal transduction molecules. Three major classes of signalling molecule are regulated by binding of D-3 phosphoinositides to PH domains: guanine-nucleotide-exchange proteins for &Rgr; family GTPases, the TEC family tyrosine kinases such as BTK and ITK in B and T lymphocytes, respectively, and the AGC superfamily of serine/threonine protein kinases. These molecules are activated by a variety of extracellular stimuli and have been implicated in a wide range of cellular processes, including cell cycle progression, cell growth, cell motility, cell adhesion and cell survival.


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