|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | |||||
Commentary |
The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
*Author for correspondence (e-mail: jkn{at}jax.org)
The identification of a mutation at the tubby (Tub) locus, which causes obesity and neurosensory degeneration, led to the discovery of the tubby-like proteins (TULPs). Tub and the genes that encode three tubby-like proteins (TULP1- TULP3) form a novel, small gene family that plays an important role in maintenance and function of neuronal cells during development and post-differentiation. Although exploration of the molecular function of these genes is still in its infancy, recent biochemical studies have provided entry points into pathways whose elucidation will further our understanding of TULP action. In addition, mRNA expression and translocation of the TUB protein have been shown to be regulated by thyroid hormone and by G-protein-coupled receptor signaling, respectively. These latter findings may help to link the cellular function of TUB to known mechanisms for energy homeostasis.
Key words: Tubby, Tubby-like protein, neuron
This article has been cited by other articles:
![]() |
Y. Yamaguchi, T. Passeron, T. Hoashi, H. Watabe, F. Rouzaud, K.-i. Yasumoto, T. Hara, C. Tohyama, I. Katayama, T. Miki, et al. Dickkopf 1 (DKK1) regulates skin pigmentation and thickness by affecting Wnt/{beta}-catenin signaling in keratinocytes FASEB J, April 1, 2008; 22(4): 1009 - 1020. [Abstract] [Full Text] [PDF] |
||||
![]() |
X. Yi, M. Schubert, N. S. Peachey, K. Suzuma, D. J. Burks, J. A. Kushner, I. Suzuma, C. Cahill, C. L. Flint, M. A. Dow, et al. Insulin Receptor Substrate 2 Is Essential for Maturation and Survival of Photoreceptor Cells J. Neurosci., February 2, 2005; 25(5): 1240 - 1248. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. P. Figlewicz, A. Zavosh, T. Sexton, and J. F. Neumaier Catabolic action of insulin in rat arcuate nucleus is not enhanced by exogenous "tub" expression Am J Physiol Endocrinol Metab, June 1, 2004; 286(6): E1004 - E1010. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. A. William, Y. Su, M. R. Smith, M. Lu, D. A. Baldwin, and D. Wagner Genomic identification of direct target genes of LEAFY PNAS, February 10, 2004; 101(6): 1775 - 1780. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. P. DiNitto, T. C. Cronin, and D. G. Lambright Membrane Recognition and Targeting by Lipid-Binding Domains Sci. Signal., December 16, 2003; 2003(213): re16 - re16. [Abstract] [Full Text] [PDF] |
||||
![]() |
D W Hommes, M P Peppelenbosch, and S J H van Deventer Mitogen activated protein (MAP) kinase signal transduction pathways and novel anti-inflammatory targets Gut, January 1, 2003; 52(1): 144 - 151. [Abstract] [Full Text] [PDF] |
||||