|
|
|
|
|
|
|
|
|||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | |||||
Commentary |
Department of Biochemistry, Molecular Biology and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL 60208, USA
* Author for correspondence (e-mail: r-morimoto{at}northwestern.edu )
Heat shock proteins interact with multiple key components of signaling pathways that regulate growth and development. The molecular relationships between heat shock proteins, various signaling proteins and partner proteins appear to be critical for the normal function of signal transduction pathways. The relative levels of these proteins may be important, as too little or too much Hsp70 or Hsp90 can result in aberrant growth control, developmental malformations and cell death. Although the functions of heat shock proteins as molecular chaperones have been well characterized, their complementary role as a `stress-induced' proteins to monitor changes and alter the biochemical environment of the cell remains elusive. Genetic and molecular interactions between heat shock proteins, their co-chaperones and components of signaling pathways suggest that crosstalk between these proteins can regulate proliferation and development by preventing or enhancing cell growth and cell death as the levels of heat shock proteins vary in response to environmental stress or disease.
Key words: Signal transduction, Hsp70, Hsp90, Bag1, Nuclear hormone receptors, Kinases, Molecular chaperones, Protein folding, Protein aggregation
Related articles in JCS:
This article has been cited by other articles:
|
|
 |
|
  E. Guisbert, T. Yura, V. A. Rhodius, and C. A. Gross Convergence of Molecular, Modeling, and Systems Approaches for an Understanding of the Escherichia coli Heat Shock Response Microbiol. Mol. Biol. Rev., September 1, 2008; 72(3): 545 - 554. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Thompson, N. J. Croft, A. Sotiriou, H. D. Piggins, and S. K. Crosthwaite Neurospora crassa heat shock factor 1 Is an Essential Gene; a Second Heat Shock Factor-Like Gene, hsf2, Is Required for Asexual Spore Formation Eukaryot. Cell, September 1, 2008; 7(9): 1573 - 1581. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. I. Morimoto Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging Genes & Dev., June 1, 2008; 22(11): 1427 - 1438. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Hirayama, Y. Yamazaki, A. Kitamura, Y. Oda, D. Morito, K. Okawa, H. Kimura, D. M. Cyr, H. Kubota, and K. Nagata MKKS Is a Centrosome-shuttling Protein Degraded by Disease-causing Mutations via CHIP-mediated Ubiquitination Mol. Biol. Cell, March 1, 2008; 19(3): 899 - 911. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-h. Xi, F. Bai, J. Gross, R. R. Townsend, A. S. Menko, and U. P. Andley Mechanism of Small Heat Shock Protein Function in Vivo: A KNOCK-IN MOUSE MODEL DEMONSTRATES THAT THE R49C MUTATION IN {alpha}A-CRYSTALLIN ENHANCES PROTEIN INSOLUBILITY AND CELL DEATH J. Biol. Chem., February 29, 2008; 283(9): 5801 - 5814. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Sidera, M. Gaitanou, D. Stellas, R. Matsas, and E. Patsavoudi A Critical Role for HSP90 in Cancer Cell Invasion Involves Interaction with the Extracellular Domain of HER-2 J. Biol. Chem., January 25, 2008; 283(4): 2031 - 2041. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. T. Jacobs and L. J. Marnett Heat Shock Factor 1 Attenuates 4-Hydroxynonenal-mediated Apoptosis: CRITICAL ROLE FOR HEAT SHOCK PROTEIN 70 INDUCTION AND STABILIZATION OF Bcl-XL J. Biol. Chem., November 16, 2007; 282(46): 33412 - 33420. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Yura, E. Guisbert, M. Poritz, C. Z. Lu, E. Campbell, and C. A. Gross Analysis of {sigma}32 mutants defective in chaperone-mediated feedback control reveals unexpected complexity of the heat shock response PNAS, November 6, 2007; 104(45): 17638 - 17643. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Qi, X. Chen, R. E. Gilbert, Y. Zhang, M. Waltham, M. Schache, D. J. Kelly, and C. A. Pollock High Glucose-Induced Thioredoxin-Interacting Protein in Renal Proximal Tubule Cells Is Independent of Transforming Growth Factor-{beta}1 Am. J. Pathol., September 1, 2007; 171(3): 744 - 754. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Hamdoun and D. Epel Embryo stability and vulnerability in an always changing world PNAS, February 6, 2007; 104(6): 1745 - 1750. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Gao and A. C. Newton Invariant Leu Preceding Turn Motif Phosphorylation Site Controls the Interaction of Protein Kinase C with Hsp70 J. Biol. Chem., October 27, 2006; 281(43): 32461 - 32468. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-K. Kim, J. Suarez, Y. Hu, P. M. McDonough, C. Boer, D. J. Dix, and W. H. Dillmann Deletion of the Inducible 70-kDa Heat Shock Protein Genes in Mice Impairs Cardiac Contractile Function and Calcium Handling Associated With Hypertrophy Circulation, June 6, 2006; 113(22): 2589 - 2597. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Citri, D. Harari, G. Shohat, P. Ramakrishnan, J. Gan, S. Lavi, M. Eisenstein, A. Kimchi, D. Wallach, S. Pietrokovski, et al. Hsp90 Recognizes a Common Surface on Client Kinases J. Biol. Chem., May 19, 2006; 281(20): 14361 - 14369. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. De Los Rios, A. Ben-Zvi, O. Slutsky, A. Azem, and P. Goloubinoff Hsp70 chaperones accelerate protein translocation and the unfolding of stable protein aggregates by entropic pulling PNAS, April 18, 2006; 103(16): 6166 - 6171. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Cen, A. Nitta, S. Ohya, Y. Zhao, N. Ozawa, A. Mouri, D. Ibi, L. Wang, M. Suzuki, K. Saito, et al. An analog of a dipeptide-like structure of FK506 increases glial cell line-derived neurotrophic factor expression through cAMP response element-binding protein activated by heat shock protein 90/Akt signaling pathway. J. Neurosci., March 22, 2006; 26(12): 3335 - 3344. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Wang, B. Thomas, R. Sachdeva, L. Arterburn, L. Frye, P. G. Hatcher, D. G. Cornwell, and J. Ma Mechanism of arylating quinone toxicity involving Michael adduct formation and induction of endoplasmic reticulum stress PNAS, March 7, 2006; 103(10): 3604 - 3609. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. H. Arlander, S. J. Felts, J. M. Wagner, B. Stensgard, D. O. Toft, and L. M. Karnitz Chaperoning Checkpoint Kinase 1 (Chk1), an Hsp90 Client, with Purified Chaperones J. Biol. Chem., February 3, 2006; 281(5): 2989 - 2998. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Wang, M. A. Khaleque, M. J. Zhao, R. Zhong, M. Gaestel, and S. K. Calderwood Phosphorylation of HSF1 by MAPK-Activated Protein Kinase 2 on Serine 121, Inhibits Transcriptional Activity and Promotes HSP90 Binding J. Biol. Chem., January 13, 2006; 281(2): 782 - 791. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. R. Stankiewicz, G. Lachapelle, C. P. Z. Foo, S. M. Radicioni, and D. D. Mosser Hsp70 Inhibits Heat-induced Apoptosis Upstream of Mitochondria by Preventing Bax Translocation J. Biol. Chem., November 18, 2005; 280(46): 38729 - 38739. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kodiha, A. Chu, O. Lazrak, and U. Stochaj Stress inhibits nucleocytoplasmic shuttling of heat shock protein hsc70 Am J Physiol Cell Physiol, October 1, 2005; 289(4): C1034 - C1041. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. E. Hofmann Patterns of Hsp gene expression in ectothermic marine organisms on small to large biogeographic scales Integr. Comp. Biol., April 1, 2005; 45(2): 247 - 255. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Morishima Control of Cell Fate by Hsp70: More than an Evanescent Meeting J. Biochem., April 1, 2005; 137(4): 449 - 453. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Petersen Shay, Z. Wang, P.-x. Xing, I. F.C. McKenzie, and N. S. Magnuson Pim-1 Kinase Stability Is Regulated by Heat Shock Proteins and the Ubiquitin-Proteasome Pathway Mol. Cancer Res., March 1, 2005; 3(3): 170 - 181. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. R. Rieger, R. I. Morimoto, and V. Hatzimanikatis Mathematical Modeling of the Eukaryotic Heat-Shock Response: Dynamics of the hsp70 Promoter Biophys. J., March 1, 2005; 88(3): 1646 - 1658. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. B. Ferguson, E. S. Anderson, R. B. Harshaw, T. Thate, N. L. Craig, and H. C. M. Nelson Protein Kinase A Regulates Constitutive Expression of Small Heat-Shock Genes in an Msn2/4p-Independent and Hsf1p-Dependent Manner in Saccharomyces cerevisiae Genetics, March 1, 2005; 169(3): 1203 - 1214. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Korbelik, J. Sun, and I. Cecic Photodynamic Therapy-Induced Cell Surface Expression and Release of Heat Shock Proteins: Relevance for Tumor Response Cancer Res., February 1, 2005; 65(3): 1018 - 1026. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Moussatche and H. J. Klee Autophosphorylation Activity of the Arabidopsis Ethylene Receptor Multigene Family J. Biol. Chem., November 19, 2004; 279(47): 48734 - 48741. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Guisbert, C. Herman, C. Z. Lu, and C. A. Gross A chaperone network controls the heat shock response in E. coli Genes & Dev., November 15, 2004; 18(22): 2812 - 2821. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Kimata, D. Oikawa, Y. Shimizu, Y. Ishiwata-Kimata, and K. Kohno A role for BiP as an adjustor for the endoplasmic reticulum stress-sensing protein Ire1 J. Cell Biol., November 8, 2004; 167(3): 445 - 456. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. R. Brasier, H. Spratt, Z. Wu, I. Boldogh, Y. Zhang, R. P. Garofalo, A. Casola, J. Pashmi, A. Haag, B. Luxon, et al. Nuclear Heat Shock Response and Novel Nuclear Domain 10 Reorganization in Respiratory Syncytial Virus-Infected A549 Cells Identified by High-Resolution Two-Dimensional Gel Electrophoresis J. Virol., November 1, 2004; 78(21): 11461 - 11476. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Le Boeuf, F. Houle, and J. Huot Regulation of Vascular Endothelial Growth Factor Receptor 2-mediated Phosphorylation of Focal Adhesion Kinase by Heat Shock Protein 90 and Src Kinase Activities J. Biol. Chem., September 10, 2004; 279(37): 39175 - 39185. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. P. Place, M. L. Zippay, and G. E. Hofmann Constitutive roles for inducible genes: evidence for the alteration in expression of the inducible hsp70 gene in Antarctic notothenioid fishes Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2004; 287(2): R429 - R436. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Myers and L. M. Mulligan The RET Receptor Is Linked to Stress Response Pathways Cancer Res., July 1, 2004; 64(13): 4453 - 4463. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Sitia and S. N. Molteni Stress, Protein (Mis)folding, and Signaling: The Redox Connection Sci. Signal., June 29, 2004; 2004(239): pe27 - pe27. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. D. Nair, T. Yuen, C. W. Olanow, and S. C. Sealfon Early Single Cell Bifurcation of Pro- and Antiapoptotic States during Oxidative Stress J. Biol. Chem., June 25, 2004; 279(26): 27494 - 27501. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. ZHU and J. TYTGAT Evolutionary epitopes of Hsp90 and p23: implications for their interaction FASEB J, June 1, 2004; 18(9): 940 - 947. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. M. Beere `The stress of dying': the role of heat shock proteins in the regulation of apoptosis J. Cell Sci., June 1, 2004; 117(13): 2641 - 2651. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Zhang, W. Wu, Y. Du, S. J. Santos, S. E. Conrad, J. T. Watson, N. Grammatikakis, and K. A. Gallo Hsp90/p50cdc37 Is Required for Mixed-lineage Kinase (MLK) 3 Signaling J. Biol. Chem., May 7, 2004; 279(19): 19457 - 19463. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. F. Morley and R. I. Morimoto Regulation of Longevity in Caenorhabditis elegans by Heat Shock Factor and Molecular Chaperones Mol. Biol. Cell, February 1, 2004; 15(2): 657 - 664. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-M. Wu, L. Xiao, X.-K. Cheng, L.-X. Cui, N.-H. Wu, and Y.-F. Shen PKC{epsilon} Is a Unique Regulator for hsp90{beta} Gene in Heat Shock Response J. Biol. Chem., December 19, 2003; 278(51): 51143 - 51149. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Fortugno, E. Beltrami, J. Plescia, J. Fontana, D. Pradhan, P. C. Marchisio, W. C. Sessa, and D. C. Altieri Regulation of survivin function by Hsp90 PNAS, November 25, 2003; 100(24): 13791 - 13796. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. de Candia, D. B. Solit, D. Giri, E. Brogi, P. M. Siegel, A. B. Olshen, W. J. Muller, N. Rosen, and R. Benezra Angiogenesis impairment in Id-deficient mice cooperates with an Hsp90 inhibitor to completely suppress HER2/neu-dependent breast tumors PNAS, October 14, 2003; 100(21): 12337 - 12342. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Adinolfi, M. Kim, M. T. Young, F. Di Virgilio, and A. Surprenant Tyrosine Phosphorylation of HSP90 within the P2X7 Receptor Complex Negatively Regulates P2X7 Receptors J. Biol. Chem., September 26, 2003; 278(39): 37344 - 37351. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Saydam, F. Steiner, O. Georgiev, and W. Schaffner Heat and Heavy Metal Stress Synergize to Mediate Transcriptional Hyperactivation by Metal-responsive Transcription Factor MTF-1 J. Biol. Chem., August 22, 2003; 278(34): 31879 - 31883. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. K. Chatterjee and R. A. Fisher Mild Heat and Proteotoxic Stress Promote Unique Subcellular Trafficking and Nucleolar Accumulation of RGS6 and Other RGS Proteins: ROLE OF THE RGS DOMAIN IN STRESS-INDUCED TRAFFICKING OF RGS PROTEINS J. Biol. Chem., August 8, 2003; 278(32): 30272 - 30282. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. McLellan, D. A. Raynes, and V. Guerriero HspBP1, an Hsp70 Cochaperone, Has Two Structural Domains and Is Capable of Altering the Conformation of the Hsp70 ATPase Domain J. Biol. Chem., May 23, 2003; 278(21): 19017 - 19022. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Grasso, C. Scifo, V. Cardile, R. Gulino, and M. Renis Adaptive Responses to the Stress Induced by Hyperthermia or Hydrogen Peroxide in Human Fibroblasts Experimental Biology and Medicine, May 1, 2003; 228(5): 491 - 498. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Slavotinek and L. G. Biesecker Genetic modifiers in human development and malformation syndromes, including chaperone proteins Hum. Mol. Genet., April 2, 2003; 12(90001): R45 - 50. [Abstract] [Full Text] [PDF]
|
|
