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Journal of Cell Science 115, 2817-2828 (2002)
© 2002 The Company of Biologists Limited

Commentary

Elastic fibres

Cay M. Kielty1,*, Michael J. Sherratt2 and C. Adrian Shuttleworth2

1 School of Medicine, University of Manchester, Manchester M13 9PT, UK
2 School of Biological Sciences, University of Manchester, Manchester M13 9PT, UK

* Author for correspondence (e-mail: cay.kielty{at}man.ac.uk )

Elastic fibres are essential extracellular matrix macromolecules comprising an elastin core surrounded by a mantle of fibrillin-rich microfibrils. They endow connective tissues such as blood vessels, lungs and skin with the critical properties of elasticity and resilience. The biology of elastic fibres is complex because they have multiple components, a tightly regulated developmental deposition, a multi-step hierarchical assembly and unique biomechanical functions. However, their molecular complexity is at last being unravelled by progress in identifying interactions between component molecules, ultrastructural analyses and studies of informative mouse models.

Key words: Elastic fibres, Microfibrils, Elastin, Fibrillin, MAGP, Fibulin


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Elastic fibres

JCS 2002 115: 1402. [Full Text]  



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