spacer gif spacer gif spacer gif spacer gif Propose a workshop for 2011 spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

doi: 10.1242/10.1242/jcs.00107

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in JCS
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hutagalung, A. H.
Right arrow Articles by Epstein, H. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hutagalung, A. H.
Right arrow Articles by Epstein, H. F.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?
Journal of Cell Science 115, 3983-3990 (2002)
Copyright © 2002 The Company of Biologists Limited
doi: 10.1242/jcs.00107

Commentary

The UCS family of myosin chaperones

Alex H. Hutagalung1, Megan L. Landsverk1, Maureen G. Price2 and Henry F. Epstein1,2,*

1 Departments of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
2 Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA

* Author for correspondence (e-mail: hepstein{at}bcm.tmc.edu)

The canonical UCS (UNC-45/Cro1/She4p) protein, Caenorhabditis elegans UNC-45, was one of the earliest molecules to be shown genetically to be necessary for sarcomere assembly. Genetic analyses of homologues in several fungal species indicate that the conserved UCS domain functionally interacts with conventional type II and unconventional type V myosins. In C. elegans and other invertebrate species, UNC-45 and its orthologues interact with both sarcomeric and non-sarcomeric myosins whereas, in vertebrates, there are two UNC-45 isoforms: a general cell (GC) and a striated muscle (SM) isoform. Although the mechanism of action of UCS proteins is unknown, recent biochemical studies suggest that they may act as molecular chaperones that facilitate the folding and/or maturation of myosin.

Key words: UCS, Myosin, chaperone, UNC-45, Protein folding


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?

Related articles in JCS:

Chaperoning myosins

JCS 2002 115: 2101. [Full Text]  



This article has been cited by other articles:


Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Lord, T. E. Sladewski, and T. D. Pollard
Yeast UCS proteins promote actomyosin interactions and limit myosin turnover in cells
PNAS, June 10, 2008; 105(23): 8014 - 8019.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Chadli, S. J. Felts, and D. O. Toft
GCUNC45 Is the First Hsp90 Co-chaperone to Show {alpha}/{beta} Isoform Specificity
J. Biol. Chem., April 11, 2008; 283(15): 9509 - 9512.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
C. Etard, U. Roostalu, and U. Strahle
Shuttling of the chaperones Unc45b and Hsp90a between the A band and the Z line of the myofibril
J. Cell Biol., March 24, 2008; 180(6): 1163 - 1175.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. J. Du, H. Li, Y. Bian, and Y. Zhong
Heat-shock protein 90{alpha}1 is required for organized myofibril assembly in skeletal muscles of zebrafish embryos
PNAS, January 15, 2008; 105(2): 554 - 559.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
M. Bazzaro, A. Santillan, Z. Lin, T. Tang, M. K. Lee, R. E. Bristow, I.-M. Shih, and R. B.S. Roden
Myosin II Co-Chaperone General Cell UNC-45 Overexpression Is Associated with Ovarian Cancer, Rapid Proliferation, and Motility
Am. J. Pathol., November 1, 2007; 171(5): 1640 - 1649.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
M. L. Landsverk, S. Li, A. H. Hutagalung, A. Najafov, T. Hoppe, J. M. Barral, and H. F. Epstein
The UNC-45 chaperone mediates sarcomere assembly through myosin degradation in Caenorhabditis elegans
J. Cell Biol., April 23, 2007; 177(2): 205 - 210.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
A. Chadli, J. D. Graham, M. G. Abel, T. A. Jackson, D. F. Gordon, W. M. Wood, S. J. Felts, K. B. Horwitz, and D. Toft
GCUNC-45 Is a Novel Regulator for the Progesterone Receptor/hsp90 Chaperoning Pathway.
Mol. Cell. Biol., March 1, 2006; 26(5): 1722 - 1730.
[Abstract] [Full Text] [PDF]

Home page
 Eukaryot CellHome page
S. H. Millson, A. W. Truman, V. King, C. Prodromou, L. H. Pearl, and P. W. Piper
A Two-Hybrid Screen of the Yeast Proteome for Hsp90 Interactors Uncovers a Novel Hsp90 Chaperone Requirement in the Activity of a Stress-Activated Mitogen-Activated Protein Kinase, Slt2p (Mpk1p)
Eukaryot. Cell, May 1, 2005; 4(5): 849 - 860.
[Abstract] [Full Text] [PDF]

Home page
 Eukaryot CellHome page
M. Mishra, V. M. D'souza, K. C. Chang, Y. Huang, and M. K. Balasubramanian
Hsp90 Protein in Fission Yeast Swo1p and UCS Protein Rng3p Facilitate Myosin II Assembly and Function
Eukaryot. Cell, March 1, 2005; 4(3): 567 - 576.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
M. Lord and T. D. Pollard
UCS protein Rng3p activates actin filament gliding by fission yeast myosin-II
J. Cell Biol., October 25, 2004; 167(2): 315 - 325.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
T. Kachur, W. Ao, J. Berger, and D. Pilgrim
Maternal UNC-45 is involved in cytokinesis and colocalizes with non-muscle myosin in the early Caenorhabditis elegans embryo
J. Cell Sci., October 15, 2004; 117(22): 5313 - 5321.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
R. Srikakulam and D. A. Winkelmann
Chaperone-mediated folding and assembly of myosin in striated muscle
J. Cell Sci., February 1, 2004; 117(4): 641 - 652.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
M. G. Price, M. L. Landsverk, J. M. Barral, and H. F. Epstein
Two mammalian UNC-45 isoforms are related to distinct cytoskeletal and muscle-specific functions
J. Cell Sci., November 1, 2002; 115(21): 4013 - 4023.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2002