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Journal of Cell Science 115, 689-698 (2002)
© 2002 The Company of Biologists Limited

Commentary

Biological roles and mechanistic actions of co-repressor complexes

Kristen Jepsen1 and Michael G. Rosenfeld1,*

1 Howard Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 920393-0648, USA

* Author for correspondence (e-mail: mrosenfeld{at}ucsd.edu )

Transcriptional repression, which plays a crucial role in diverse biological processes, is mediated in part by non-DNA-binding co-repressors. The closely related co-repressor proteins N-CoR and SMRT, although originally identified on the basis of their ability to associate with and confer transcriptional repression through nuclear receptors, have been shown to be recruited to many classes of transcription factor and are in fact components of multiple protein complexes containing histone deacetylase proteins. This association with histone deacetylase activity provides an important component of the mechanism that allows DNA-binding proteins interacting with N-CoR or SMRT to repress transcription of specific target genes. Both N-CoR and SMRT are important targets for cell signaling pathways, which influence their expression levels, subcellular localization and association with other proteins. Recently, the biological importance of these proteins has been revealed by studies of genetically engineered mice and human diseases such as acute promyelocytic leukemia (APL) and resistance to thyroid hormone (RTH).

Key words: N-CoR, SMRT, Co-repressor, HDAC


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N-CoR and SMRT co-repressors (p. 689)

JCS 2002 115: 401. [Full Text]  



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[Abstract] [Full Text] [PDF]

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J. Cell Biol., June 20, 2005; 169(6): 847 - 857.
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[Abstract] [Full Text] [PDF]

Home page
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J. Biol. Chem., November 19, 2004; 279(47): 49281 - 49288.
[Abstract] [Full Text] [PDF]

Home page
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Mol. Cell. Biol., October 15, 2004; 24(20): 8862 - 8871.
[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

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Development, September 1, 2004; 131(17): 4189 - 4200.
[Abstract] [Full Text] [PDF]

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[Abstract] [Full Text] [PDF]

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[Abstract] [Full Text] [PDF]

Home page
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J. Biochem., August 1, 2004; 136(2): 169 - 176.
[Abstract] [Full Text] [PDF]

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[Abstract] [Full Text] [PDF]

Home page
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J. Biol. Chem., June 18, 2004; 279(25): 26074 - 26081.
[Abstract] [Full Text] [PDF]

Home page
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Mol. Cell. Biol., June 15, 2004; 24(12): 5496 - 5509.
[Abstract] [Full Text] [PDF]

Home page
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Home page
 EndocrinologyHome page
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Endocrinology, April 1, 2004; 145(4): 1525 - 1526.
[Full Text] [PDF]

Home page
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Mol. Cell. Biol., January 1, 2004; 24(1): 306 - 319.
[Abstract] [Full Text] [PDF]

Home page
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J. Biol. Chem., October 10, 2003; 278(41): 39296 - 39302.
[Abstract] [Full Text] [PDF]

Home page
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Mol. Cell. Biol., October 1, 2003; 23(19): 6750 - 6758.
[Abstract] [Full Text] [PDF]

Home page
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J. Biol. Chem., August 29, 2003; 278(35): 32489 - 32492.
[Abstract] [Full Text] [PDF]

Home page
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J. Biol. Chem., August 15, 2003; 278(33): 30788 - 30795.
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Home page
 Endocr. Rev.Home page
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[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
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J. Biol. Chem., June 27, 2003; 278(27): 24858 - 24864.
[Abstract] [Full Text] [PDF]

Home page
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F. Zhao, R. McCarrick-Walmsley, P. Akerblad, M. Sigvardsson, and T. Kadesch
Inhibition of p300/CBP by Early B-Cell Factor
Mol. Cell. Biol., June 1, 2003; 23(11): 3837 - 3846.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
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J. Biol. Chem., May 23, 2003; 278(21): 19209 - 19219.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
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J. Biol. Chem., May 23, 2003; 278(22): 20059 - 20068.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
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J. Immunol., March 15, 2003; 170(6): 3125 - 3133.
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