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Journal of Cell Science 115, 737-744 (2002)
© 2002 The Company of Biologists Limited

Research Article

Two members of the beige/CHS (BEACH) family are involved at different stages in the organization of the endocytic pathway in Dictyostelium

Sophie Cornillon1, Annick Dubois2, Franz Brückert3, Yaya Lefkir2, Anna Marchetti1, Mohammed Benghezal1, Arturo De Lozanne4, François Letourneur2 and Pierre Cosson1,*

1 Université de Genève, Centre Médical Universitaire, Département de morphologie, 1 Rue Michel Servet, CH1211 Genève 4, Switzerland
2 Institut de Biologie et de Chimie des Protéines, UMR5086-CNRS, Université Lyon I, 7 Passage du Vercors, 69367 Lyon cedex 07, France
3 Laboratoire de Biochimie et Biophysique des Systèmes Intégrés, UMR314 CNRS, CEA, 38054 Grenoble, France
4 Section of Molecular Cell and Developmental Biology and Institute for Cellular and Molecular Biology, 241 Patterson Bldg., Mail code C0930, University of Texas, Austin, TX 78712, USA

* Author for correspondence (e-mail: Pierre.Cosson{at}medecine.unige.ch )

Accepted 5 November 2001

Proteins of the Chediak-Higashi/Beige (BEACH) family have been implicated in the function of lysosomes, as well as in signal transduction, but their molecular role is still poorly understood. In Dictyostelium, at least six members of the family can be identified. Here cells with mutations in two of these genes, LVSA and LVSB, were analyzed. Interestingly both mutants exhibited defects in the organization of the endocytic pathway, albeit at distinct stages. In lvsB mutant cells, the regulated secretion of lysosomal enzymes was enhanced, a phenotype reminiscent of the Chediak-Higashi syndrome. LvsA mutant cells exhibited alterations in the organization and function of the early endocytic and phagocytic pathway. The LvsA protein may participate in the signaling pathway, which links adhesion of a particle to the subsequent formation of a phagocytic cup. Further genetic analysis will be necessary to determine whether other members of the BEACH family of proteins are also involved in controlling the organization of the endocytic pathway.

Key words: Beige, BEACH domain, Chediak-Higashi, phagocytosis, lysosome, Lvs, Dictyostelium


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