QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Kim, J. Articles by Carlson, J. R. Search for Related Content PubMed PubMed Citation Articles by Kim, J. Articles by Carlson, J. R. Social Bookmarking                         What's this?

Gene discovery by e-genetics: Drosophila odor and taste receptors

¹ Department of Molecular, Cellular and Developmental Biology, Yale University, P.O. Box 208103, New Haven, CT 06520-8103, USA
² Department of Ecology and Evolutionary Biology and Department of Statistics, Yale University, P.O. Box 208106, New Haven, CT 06520-8106, USA

^* Author for correspondence (e-mail: john.carlson{at}yale.edu )

A new algorithm that examines DNA databases for proteins that have a particular structure, as opposed to a particular sequence, represents a novel `e-genetics' approach to gene discovery. The algorithm has successfully identified new G-protein-coupled receptors, which have a characteristic seven-transmembrane-domain structure, from the Drosophila genome database. In particular, it has revealed novel families of odor receptors and taste receptors, which had long eluded identification by other means. The two new gene families, the Or and Gr genes, are expressed in neurons of olfactory and taste sensilla and are highly divergent from all other known G-protein-coupled receptor genes. Modification of the algorithm should allow identification of other classes of multitransmembrane-domain protein.

Key words: Receptor, Olfaction, Taste, Drosophila, G-protein-coupled receptor

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				S. Guo and J. Kim Molecular Evolution of Drosophila Odorant Receptor Genes Mol. Biol. Evol., May 1, 2007; 24(5): 1198 - 1207. [Abstract] [Full Text] [PDF]

				H. M. Robertson, C. G. Warr, and J. R. Carlson Molecular evolution of the insect chemoreceptor gene superfamily in Drosophila melanogaster PNAS, November 25, 2003; 100(suppl_2): 14537 - 14542. [Abstract] [Full Text]