|
|
|
|
|
|
|
|
|||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | |||||
Commentary |
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
e-mail: bouillet{at}wehi.edu.au or strasser{at}wehi.edu.au
The BH3-only members of the Bcl-2 protein family are essential initiators of programmed cell death and are required for apoptosis induced by cytotoxic stimuli. These proteins have evolved to recognise distinct forms of cell stress. In response, they unleash the apoptotic cascade by inactivating the protective function of the pro-survival members of the Bcl-2 family and by activating the Bax/Bax-like pro-apoptotic family members.
Key words: Apoptosis, Cell death, Bcl-2, BH3-only proteins, Signal transduction
Related articles in JCS:
This article has been cited by other articles:
|
|
 |
|
  K. F. Wan, S.-L. Chan, S. K. Sukumaran, M.-C. Lee, and V. C. Yu Chelerythrine Induces Apoptosis through a Bax/Bak-independent Mitochondrial Mechanism J. Biol. Chem., March 28, 2008; 283(13): 8423 - 8433. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Diwan, J. Wansapura, F. M. Syed, S. J. Matkovich, J. N. Lorenz, and G. W. Dorn II Nix-Mediated Apoptosis Links Myocardial Fibrosis, Cardiac Remodeling, and Hypertrophy Decompensation Circulation, January 22, 2008; 117(3): 396 - 404. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Luhrmann and C. R. Roy Coxiella burnetii Inhibits Activation of Host Cell Apoptosis through a Mechanism That Involves Preventing Cytochrome c Release from Mitochondria Infect. Immun., November 1, 2007; 75(11): 5282 - 5289. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. W. Moseley, D. M. Roth, M. A. DeJesus, D. L. Leyton, R. P. Filmer, C. W. Pouton, and D. A. Jans Dynein Light Chain Association Sequences Can Facilitate Nuclear Protein Import Mol. Biol. Cell, August 1, 2007; 18(8): 3204 - 3213. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Diwan, A. G. Koesters, A. M. Odley, S. Pushkaran, C. P. Baines, B. T. Spike, D. Daria, A. G. Jegga, H. Geiger, B. J. Aronow, et al. Unrestrained erythroblast development in Nix-/- mice reveals a mechanism for apoptotic modulation of erythropoiesis PNAS, April 17, 2007; 104(16): 6794 - 6799. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Ekoff, A. Strasser, and G. Nilsson Fc{epsilon}RI Aggregation Promotes Survival of Connective Tissue-Like Mast Cells but Not Mucosal-Like Mast Cells J. Immunol., April 1, 2007; 178(7): 4177 - 4183. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. M. Mhaidat, Y. Wang, K. A. Kiejda, X. D. Zhang, and P. Hersey Docetaxel-induced apoptosis in melanoma cells is dependent on activation of caspase-2 Mol. Cancer Ther., February 1, 2007; 6(2): 752 - 761. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Benito, O. Gutierrez, C. Pipaon, P. J. Real, F. Gachon, A. E. Ritchie, and J. L. Fernandez-Luna A Novel Role for Proline- and Acid-rich Basic Region Leucine Zipper (PAR bZIP) Proteins in the Transcriptional Regulation of a BH3-only Proapoptotic Gene J. Biol. Chem., December 15, 2006; 281(50): 38351 - 38357. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Pirbhai, F. Dong, Y. Zhong, K. Z. Pan, and G. Zhong The Secreted Protease Factor CPAF Is Responsible for Degrading Pro-apoptotic BH3-only Proteins in Chlamydia trachomatis-infected Cells J. Biol. Chem., October 20, 2006; 281(42): 31495 - 31501. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Naresh, W. Long, G. A. Vidal, W. C. Wimley, L. Marrero, C. I. Sartor, S. Tovey, T. G. Cooke, J. M.S. Bartlett, and F. E. Jones The ERBB4/HER4 Intracellular Domain 4ICD Is a BH3-Only Protein Promoting Apoptosis of Breast Cancer Cells. Cancer Res., June 15, 2006; 66(12): 6412 - 6420. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Liu, R. Dawes, S. Petrova, P. C. Beverley, and E. Z Tchilian CD45 regulates apoptosis in peripheral T lymphocytes Int. Immunol., June 1, 2006; 18(6): 959 - 966. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. W. Ward, M. Rehm, H. Duessmann, S. Kacmar, C. G. Concannon, and J. H. M. Prehn Real Time Single Cell Analysis of Bid Cleavage and Bid Translocation during Caspase-dependent and Neuronal Caspase-independent Apoptosis J. Biol. Chem., March 3, 2006; 281(9): 5837 - 5844. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Manka, Z. Spicer, and D. E. Millhorn Bcl-2/Adenovirus E1B 19 kDa Interacting Protein-3 Knockdown Enables Growth of Breast Cancer Metastases in the Lung, Liver, and Bone Cancer Res., December 15, 2005; 65(24): 11689 - 11693. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. K. Wong, M. Fricker, A. Wyttenbach, A. Villunger, E. M. Michalak, A. Strasser, and A. M. Tolkovsky Mutually Exclusive Subsets of BH3-Only Proteins Are Activated by the p53 and c-Jun N-Terminal Kinase/c-Jun Signaling Pathways during Cortical Neuron Apoptosis Induced by Arsenite Mol. Cell. Biol., October 1, 2005; 25(19): 8732 - 8747. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Morrison, M. A. English, and J. D. Licht WT1 Induces Apoptosis through Transcriptional Regulation of the Proapoptotic Bcl-2 Family Member Bak Cancer Res., September 15, 2005; 65(18): 8174 - 8182. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Mathai, M. Germain, and G. C. Shore BH3-only BIK Regulates BAX,BAK-dependent Release of Ca2+ from Endoplasmic Reticulum Stores and Mitochondrial Apoptosis during Stress-induced Cell Death J. Biol. Chem., June 24, 2005; 280(25): 23829 - 23836. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. Garcia-Saez, M. Coraiola, M. Dalla Serra, I. Mingarro, G. Menestrina, and J. Salgado Peptides Derived from Apoptotic Bax and Bid Reproduce the Poration Activity of the Parent Full-Length Proteins Biophys. J., June 1, 2005; 88(6): 3976 - 3990. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. A. Vidal, A. Naresh, L. Marrero, and F. E. Jones Presenilin-dependent {gamma}-Secretase Processing Regulates Multiple ERBB4/HER4 Activities J. Biol. Chem., May 20, 2005; 280(20): 19777 - 19783. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Uo, Y. Kinoshita, and R. S. Morrison Neurons Exclusively Express N-Bak, a BH3 Domain-only Bak Isoform That Promotes Neuronal Apoptosis J. Biol. Chem., March 11, 2005; 280(10): 9065 - 9073. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Ying, B. M. Seiffert, G. Hacker, and S. F. Fischer Broad Degradation of Proapoptotic Proteins with the Conserved Bcl-2 Homology Domain 3 during Infection with Chlamydia trachomatis Infect. Immun., March 1, 2005; 73(3): 1399 - 1403. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Dong, M. Pirbhai, Y. Xiao, Y. Zhong, Y. Wu, and G. Zhong Degradation of the Proapoptotic Proteins Bik, Puma, and Bim with Bcl-2 Domain 3 Homology in Chlamydia trachomatis-Infected Cells Infect. Immun., March 1, 2005; 73(3): 1861 - 1864. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Klee and F. X. Pimentel-Muinos Bcl-XL specifically activates Bak to induce swelling and restructuring of the endoplasmic reticulum J. Cell Biol., February 28, 2005; 168(5): 723 - 734. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Gerl and D. L. Vaux Apoptosis in the development and treatment of cancer Carcinogenesis, February 1, 2005; 26(2): 263 - 270. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kirschnek, S. Ying, S. F. Fischer, H. Hacker, A. Villunger, H. Hochrein, and G. Hacker Phagocytosis-Induced Apoptosis in Macrophages Is Mediated by Up-Regulation and Activation of the Bcl-2 Homology Domain 3-Only Protein Bim J. Immunol., January 15, 2005; 174(2): 671 - 679. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-R. Liu, E. Gao, A. Hu, L. Tao, Y. Qu, P. Most, W. J. Koch, T. A. Christopher, B. L. Lopez, E. S. Alnemri, et al. Role of Omi/HtrA2 in Apoptotic Cell Death After Myocardial Ischemia and Reperfusion Circulation, January 4, 2005; 111(1): 90 - 96. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Hess, P. Angel, and M. Schorpp-Kistner AP-1 subunits: quarrel and harmony among siblings J. Cell Sci., December 1, 2004; 117(25): 5965 - 5973. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Papa, F. Zazzeroni, C. G. Pham, C. Bubici, and G. Franzoso Linking JNK signaling to NF-{kappa}B: a key to survival J. Cell Sci., October 15, 2004; 117(22): 5197 - 5208. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. F. Fischer, J. Vier, S. Kirschnek, A. Klos, S. Hess, S. Ying, and G. Hacker Chlamydia Inhibit Host Cell Apoptosis by Degradation of Proapoptotic BH3-only Proteins J. Exp. Med., October 4, 2004; 200(7): 905 - 916. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Mayorga, N. Bahi, M. Ballester, J. X. Comella, and D. Sanchis Bcl-2 Is a Key Factor for Cardiac Fibroblast Resistance to Programmed Cell Death J. Biol. Chem., August 13, 2004; 279(33): 34882 - 34889. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Valentijn and A. P. Gilmore Translocation of Full-length Bid to Mitochondria during Anoikis J. Biol. Chem., July 30, 2004; 279(31): 32848 - 32857. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. G. Broustas, P. C. Gokhale, A. Rahman, A. Dritschilo, I. Ahmad, and U. Kasid BRCC2, a Novel BH3-like Domain-containing Protein, Induces Apoptosis in a Caspase-dependent Manner J. Biol. Chem., June 18, 2004; 279(25): 26780 - 26788. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. M. Beere `The stress of dying': the role of heat shock proteins in the regulation of apoptosis J. Cell Sci., June 1, 2004; 117(13): 2641 - 2651. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Han, L. A. Goldstein, B. R. Gastman, C. J. Froelich, X.-M. Yin, and H. Rabinowich Degradation of Mcl-1 by Granzyme B: IMPLICATIONS FOR Bim-MEDIATED MITOCHONDRIAL APOPTOTIC EVENTS J. Biol. Chem., May 21, 2004; 279(21): 22020 - 22029. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Zhang and P. A. Insel The Pro-apoptotic Protein Bim Is a Convergence Point for cAMP/Protein Kinase A- and Glucocorticoid-promoted Apoptosis of Lymphoid Cells J. Biol. Chem., May 14, 2004; 279(20): 20858 - 20865. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Imaizumi, A. Benito, S. Kiryu-Seo, V. Gonzalez, N. Inohara, A. P. Leiberman, H. Kiyama, and G. Nunez Critical Role for DP5/Harakiri, a Bcl-2 Homology Domain 3-Only Bcl-2 Family Member, in Axotomy-Induced Neuronal Cell Death J. Neurosci., April 14, 2004; 24(15): 3721 - 3725. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. D. Zhang, S. K. Gillespie, and P. Hersey Staurosporine induces apoptosis of melanoma by both caspase-dependent and -independent apoptotic pathways Mol. Cancer Ther., February 1, 2004; 3(2): 187 - 197. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. S. Sulistijo, T. M. Jaszewski, and K. R. MacKenzie Sequence-specific Dimerization of the Transmembrane Domain of the "BH3-only" Protein BNIP3 in Membranes and Detergent J. Biol. Chem., December 19, 2003; 278(51): 51950 - 51956. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Pervin, R. Singh, W. A. Freije, and G. Chaudhuri MKP-1-Induced Dephosphorylation of Extracellular Signal-Regulated Kinase Is Essential for Triggering Nitric Oxide-Induced Apoptosis in Human Breast Cancer Cell Lines: Implications in Breast Cancer Cancer Res., December 15, 2003; 63(24): 8853 - 8860. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Thomenius and C. W. Distelhorst Bcl-2 on the endoplasmic reticulum: protecting the mitochondria from a distance J. Cell Sci., November 15, 2003; 116(22): 4493 - 4499. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Zazzeroni, S. Papa, A. Algeciras-Schimnich, K. Alvarez, T. Melis, C. Bubici, N. Majewski, N. Hay, E. De Smaele, M. E. Peter, et al. Gadd45{beta} mediates the protective effects of CD40 costimulation against Fas-induced apoptosis Blood, November 1, 2003; 102(9): 3270 - 3279. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. H. Maclean, U. B. Keller, C. Rodriguez-Galindo, J. A. Nilsson, and J. L. Cleveland c-Myc Augments Gamma Irradiation-Induced Apoptosis by Suppressing Bcl-XL Mol. Cell. Biol., October 15, 2003; 23(20): 7256 - 7270. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Haupt, M. Berger, Z. Goldberg, and Y. Haupt Apoptosis - the p53 network J. Cell Sci., October 15, 2003; 116(20): 4077 - 4085. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Adams Ways of dying: multiple pathways to apoptosis Genes & Dev., October 15, 2003; 17(20): 2481 - 2495. [Full Text] [PDF]
|
|
|
|
|
|
T. Shibue, K. Takeda, E. Oda, H. Tanaka, H. Murasawa, A. Takaoka, Y. Morishita, S. Akira, T. Taniguchi, and N. Tanaka Integral role of Noxa in p53-mediated apoptotic response Genes & Dev., September 15, 2003; 17(18): 2233 - 2238. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P.-F. Cartron, P. Juin, L. Oliver, S. Martin, K. Meflah, and F. M. Vallette Nonredundant Role of Bax and Bak in Bid-Mediated Apoptosis Mol. Cell. Biol., July 1, 2003; 23(13): 4701 - 4712. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Wang, M. Nguyen, D. G. Breckenridge, M. Stojanovic, P. A. Clemons, S. Kuppig, and G. C. Shore Uncleaved BAP31 in Association with A4 Protein at the Endoplasmic Reticulum Is an Inhibitor of Fas-initiated Release of Cytochrome c from Mitochondria J. Biol. Chem., April 11, 2003; 278(16): 14461 - 14468. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Henderson, M. Mizzau, G. Paroni, R. Maestro, C. Schneider, and C. Brancolini Role of Caspases, Bid, and p53 in the Apoptotic Response Triggered by Histone Deacetylase Inhibitors Trichostatin-A (TSA) and Suberoylanilide Hydroxamic Acid (SAHA) J. Biol. Chem., March 28, 2003; 278(14): 12579 - 12589. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Lei and R. J. Davis JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis PNAS, March 4, 2003; 100(5): 2432 - 2437. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Yu, Z. Wang, K. W. Kinzler, B. Vogelstein, and L. Zhang PUMA mediates the apoptotic response to p53 in colorectal cancer cells PNAS, February 18, 2003; 100(4): 1931 - 1936. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. C. Biswas and L. A. Greene Nerve Growth Factor (NGF) Down-regulates the Bcl-2 Homology 3 (BH3) Domain-only Protein Bim and Suppresses Its Proapoptotic Activity by Phosphorylation J. Biol. Chem., December 13, 2002; 277(51): 49511 - 49516. [Abstract] [Full Text] [PDF]
|
|
