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Journal of Cell Science 115, 1575-1581 (2002)
© 2002 The Company of Biologists Limited

Commentary

Extracellular signal regulated kinase (ERK)/mitogen activated protein kinase (MAPK)-independent functions of Raf kinases

Alison Hindley1 and Walter Kolch1,2,*

1 The Beatson Institute for Cancer Research, CRC Beatson Laboratories, Glasgow, G61 1BD, UK
2 Institute for Biomedical and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK

* Author for correspondence (e-mail: wkolch{at}beatson.gla.ac.uk )

Raf comprises a family of three kinases, A-Raf, B-Raf and Raf-1, which are best known as key regulators of the MEK—MAPK/ERK cascade. This module is often perceived as a linear pathway in which ERK is the effector. However, recent advances have unveiled a role for Raf outside this established signalling unit. Current evidence, including gene-knockout studies in mice, suggests that there are ERK-independent functions of Raf kinases. Regulation of apoptosis is one area in which Raf may function independently of ERK, although its substrates remain to be identified. Other studies have suggested that Raf has kinase-independent functions and may act as a scaffold protein.

Key words: Raf, Apoptosis, ERK/MAPK, Knockout mice, Signal transduction


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© The Company of Biologists Ltd 2002