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doi: 10.1242/10.1242/jcs.00407
Commentary |
MRC Immunochemistry Unit, Department of Biochemistry, South Parks Road, Oxford OX1 3QU, UK
* Author for correspondence (e-mail: tony.day{at}bioch.ox.ac.uk)
TSG-6 expression is upregulated in many cell types in response to a variety
of proinflammatory mediators and growth factors. This protein is detected in
several inflammatory disease states (e.g. rheumatoid arthritis) and in the
context of inflammation-like processes, such as ovulation, and is often
associated with extracellular matrix remodelling. TSG-6 has anti-inflammatory
and chondroprotective effects in various models of inflammation and arthritis,
which suggest that it is a component of a negative feedback loop capable of
downregulating the inflammatory response. Growing evidence also indicates that
TSG-6 acts as a crucial factor in ovulation by influencing the expansion of
the hyaluronan-rich cumulus extracellular matrix in the preovulatory follicle.
TSG-6 is a member of the Link module superfamily and binds to hyaluronan (a
vital component of extracellular matrix), as well as other glycosaminoglycans,
via its Link module. In addition, TSG-6 forms both covalent and non-covalent
complexes with inter-
-inhibitor (a serine protease inhibitor present at
high levels in serum) and potentiates its anti-plasmin activity.
Key words: TSG-6, Hyaluronan, Inter--inhibitor, Ovulation, Inflammation, Arthritis
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