QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

doi: 10.1242/10.1242/jcs.00488

This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Schnapp, B. J. Search for Related Content PubMed PubMed Citation Articles by Schnapp, B. J.

Trafficking of signaling modules by kinesin motors

Department of Cell and Developmental Biology, Oregon Health Sciences University, Portland, OR 97201-3098, USA

(e-mail: schnappb{at}ohsu.edu)

The human genome has more than 40 kinesin genes whose protein products organize intracellular traffic along microtubules. Research during the past two years has begun to elucidate the cargoes carried by kinesins and the nature of the kinesin-cargo linkage. Modular protein-protein interactions connect kinesins to diverse cellular molecules, which, apart from their other functions, serve as kinesin-cargo linkers. Many of these newly identified linkers are scaffolds for signaling pathways, and mounting evidence now indicates that kinesins transport pre-assembled signaling modules as vesicular cargo. These findings bring together two fields, signal transduction and molecular motors, and lead to a deeper understanding of the interplay between trafficking, localization and intercellular communication.

Key words: Kinesin, Scaffold, Signal transduction, Motors, Cytoskeleton, Protein trafficking

Related articles in JCS:

Motors for signalling modules

JCS 2003 116: 1101. [Full Text]  

This article has been cited by other articles:

				S. Dunn, E. E. Morrison, T. B. Liverpool, C. Molina-Paris, R. A. Cross, M. C. Alonso, and M. Peckham Differential trafficking of Kif5c on tyrosinated and detyrosinated microtubules in live cells J. Cell Sci., April 1, 2008; 121(7): 1085 - 1095. [Abstract] [Full Text] [PDF]

				D. Shiffman, D. I. Chasman, R. Y.L. Zee, O. A. Iakoubova, J. Z. Louie, J. J. Devlin, and P. M. Ridker A kinesin family member 6 variant is associated with coronary heart disease in the Women's Health Study. J. Am. Coll. Cardiol., January 29, 2008; 51(4): 444 - 448. [Abstract] [Full Text] [PDF]

				R. V. Barkus, O. Klyachko, D. Horiuchi, B. J. Dickson, and W. M. Saxton Identification of an Axonal Kinesin-3 Motor for Fast Anterograde Vesicle Transport that Facilitates Retrograde Transport of Neuropeptides Mol. Biol. Cell, January 1, 2008; 19(1): 274 - 283. [Abstract] [Full Text] [PDF]

				N. Terada, N. Ohno, S. Saitoh, G. Seki, M. Komada, T. Suzuki, H. Yamakawa, M. Soleimani, and S. Ohno Interaction of Membrane Skeletal Protein, Protein 4.1B and p55, and Sodium Bicarbonate Cotransporter1 in Mouse Renal S1-S2 Proximal Tubules J. Histochem. Cytochem., December 1, 2007; 55(12): 1199 - 1206. [Abstract] [Full Text] [PDF]

				J. B. Silverman, S. Restituito, W. Lu, L. Lee-Edwards, L. Khatri, and E. B. Ziff Synaptic Anchorage of AMPA Receptors by Cadherins through Neural Plakophilin-Related Arm Protein AMPA Receptor-Binding Protein Complexes J. Neurosci., August 8, 2007; 27(32): 8505 - 8516. [Abstract] [Full Text] [PDF]

				Y. Fang, A. M. Ferrie, N. H. Fontaine, J. Mauro, and J. Balakrishnan Resonant Waveguide Grating Biosensor for Living Cell Sensing Biophys. J., September 1, 2006; 91(5): 1925 - 1940. [Abstract] [Full Text] [PDF]

				K. Kabu, S. Yamasaki, D. Kamimura, Y. Ito, A. Hasegawa, E. Sato, H. Kitamura, K. Nishida, and T. Hirano Zinc Is Required for Fc{epsilon}RI-Mediated Mast Cell Activation J. Immunol., July 15, 2006; 177(2): 1296 - 1305. [Abstract] [Full Text] [PDF]

				Y.-R. J. Lee and B. Liu Cytoskeletal Motors in Arabidopsis. Sixty-One Kinesins and Seventeen Myosins Plant Physiology, December 1, 2004; 136(4): 3877 - 3883. [Full Text] [PDF]

				M. E. K. Olsten, D. A. Canton, C. Zhang, P. A. Walton, and D. W. Litchfield The Pleckstrin Homology Domain of CK2 Interacting Protein-1 Is Required for Interactions and Recruitment of Protein Kinase CK2 to the Plasma Membrane J. Biol. Chem., October 1, 2004; 279(40): 42114 - 42127. [Abstract] [Full Text] [PDF]

				C. Weaver and D. Kimelman Move it or lose it: axis specification in Xenopus Development, August 1, 2004; 131(15): 3491 - 3499. [Abstract] [Full Text] [PDF]

				L. Davidson, A. J. Pawson, R. L. de Maturana, S. H. Freestone, P. Barran, R. P. Millar, and S. Maudsley Gonadotropin-releasing Hormone-induced Activation of Diacylglycerol Kinase-{zeta} and Its Association with Active c-Src J. Biol. Chem., March 19, 2004; 279(12): 11906 - 11916. [Abstract] [Full Text] [PDF]