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First published online July 10, 2003
doi: 10.1242/10.1242/jcs.00667
Commentary |
1 Department of Chemistry, Graduate School of Science, Nagoya University,
Chikusa-ku, Nagoya 464-8602, Japan
2 Core Research for Evolutional Science and Technology, Japan Science and
Technology Corporation, Japan
* Author for correspondence (e-mail: endo{at}biochem.chem.nagoya-u.ac.jp)
Nearly all mitochondrial proteins are synthesized in the cytosol and
subsequently imported into mitochondria with the aid of translocators: the TOM
complex in the outer membrane, and the TIM23 and TIM22 complexes in the inner
membrane. The TOM complex and the TIM complexes cooperate to achieve efficient
transport of proteins to the matrix or into the inner membrane and several
components, including Tom22, Tim23, Tim50 and small Tim proteins, mediate
functional coupling of the two translocator systems. The TOM complex can be
disconnected from the TIM systems and their energy sources (ATP and
), however, using alternative mechanisms to achieve vectorial
protein translocation across the outer membrane
Key words: Mitochondria, Protein import, Translocator, TOM, TIM
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