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First published online 2 July 2003
doi: 10.1242/jcs.00649

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Journal of Cell Science 116, 3387-3397 (2003)
doi: 10.1242/jcs.00649

Research Article

Superoxide signalling required for multicellular development of Dictyostelium

Gareth Bloomfield* and Catherine Pears{ddagger}

Biochemistry Department, Oxford University, South Parks Road, Oxford OX1 3QU, UK

{ddagger} Author for correspondence (e-mail: pears{at}bioch.ox.ac.uk)

Accepted 6 May 2003

Reactive oxygen species are known to have a signalling role in many organisms. In bacteria and yeast various response systems have evolved to combat oxidative stress which are triggered by reactive oxygen species. Mammals and plants are known to actively generate reactive oxygen species such as superoxide during signalling responses to a variety of extracellular factors. We report here the generation of superoxide as a signalling molecule in early development of Dictyostelium discoideum. Dictyostelium grows as single amoebae but, on starvation, the single cells aggregate to form a multicellular organism. Superoxide is generated in response to a secreted factor during the transition to the multicellular phase of development. Scavenging superoxide, either pharmacologically or by overexpressing the enzyme superoxide dismutase, inhibits the formation of the aggregate. This report of the use of superoxide as a signalling molecule in a lower eukaryote as it switches to a multicellular phase suggests that this signalling mechanism arose early in the evolution of multicellular organisms, perhaps as a necessary consequence of the need to diversify the number and type of signalling pathways available to facilitate intercellular communication.

Key words: Superoxide, Cell signalling, Dictyostelium discoideum, Superoxide dismutase


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© The Company of Biologists Ltd 2003