QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

doi: 10.1242/10.1242/jcs.00248

This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Starr, D. A. Articles by Han, M. Search for Related Content PubMed PubMed Citation Articles by Starr, D. A. Articles by Han, M.

ANChors away: an actin based mechanism of nuclear positioning

Howard Hughes Medical Institute and Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309, USA

^* Author for correspondence (e-mail: daniel.starr{at}colorado.edu)

Mechanisms for nuclear migration and nuclear anchorage function together to control nuclear positioning. Both tubulin and actin networks play important roles in nuclear positioning. The actin cytoskeleton has been shown to position nuclei in a variety of systems from yeast to plants and animals. It can either act as a stable skeleton to anchor nuclei or supply the active force to move nuclei. Two C. elegans genes and their homologues play important roles in these processes. Syne/ANC-1 anchors nuclei by directly tethering the nuclear envelope to the actin cytoskeleton, and UNC-84/SUN functions at the nuclear envelope to recruit Syne/ANC-1.

Key words: Nuclear migration, Nuclear anchorage, UNC-84, SUN domain, ANC-1, Muscular dystrophy, Nuclear envelope

Related articles in JCS:

Nuclear ANChors

JCS 2003 116: 202. [Full Text]  

This article has been cited by other articles:

				Y. Luke, H. Zaim, I. Karakesisoglou, V. M. Jaeger, L. Sellin, W. Lu, M. Schneider, S. Neumann, A. Beijer, M. Munck, et al. Nesprin-2 Giant (NUANCE) maintains nuclear envelope architecture and composition in skin J. Cell Sci., June 1, 2008; 121(11): 1887 - 1898. [Abstract] [Full Text] [PDF]

				Q. Zhang, C. Bethmann, N. F. Worth, J. D. Davies, C. Wasner, A. Feuer, C. D. Ragnauth, Q. Yi, J. A. Mellad, D. T. Warren, et al. Nesprin-1 and -2 are involved in the pathogenesis of Emery Dreifuss muscular dystrophy and are critical for nuclear envelope integrity Hum. Mol. Genet., December 1, 2007; 16(23): 2816 - 2833. [Abstract] [Full Text] [PDF]

				M. Ketema, K. Wilhelmsen, I. Kuikman, H. Janssen, D. Hodzic, and A. Sonnenberg Requirements for the localization of nesprin-3 at the nuclear envelope and its interaction with plectin J. Cell Sci., October 1, 2007; 120(19): 3384 - 3394. [Abstract] [Full Text] [PDF]

				J. S. H. Lee, C. M. Hale, P. Panorchan, S. B. Khatau, J. P. George, Y. Tseng, C. L. Stewart, D. Hodzic, and D. Wirtz Nuclear Lamin A/C Deficiency Induces Defects in Cell Mechanics, Polarization, and Migration Biophys. J., October 1, 2007; 93(7): 2542 - 2552. [Abstract] [Full Text] [PDF]

				Y.-H. Chi, K. Haller, J.-M. Peloponese Jr., and K.-T. Jeang Histone Acetyltransferase hALP and Nuclear Membrane Protein hsSUN1 Function in De-condensation of Mitotic Chromosomes J. Biol. Chem., September 14, 2007; 282(37): 27447 - 27458. [Abstract] [Full Text] [PDF]

				M. Tsujikawa, Y. Omori, J. Biyanwila, and J. Malicki Mechanism of positioning the cell nucleus in vertebrate photoreceptors PNAS, September 11, 2007; 104(37): 14819 - 14824. [Abstract] [Full Text] [PDF]

				M. N. Conrad, C.-Y. Lee, J. L. Wilkerson, and M. E. Dresser MPS3 mediates meiotic bouquet formation in Saccharomyces cerevisiae PNAS, May 22, 2007; 104(21): 8863 - 8868. [Abstract] [Full Text] [PDF]

				J. Schmitt, R. Benavente, D. Hodzic, C. Hoog, C. L. Stewart, and M. Alsheimer Transmembrane protein Sun2 is involved in tethering mammalian meiotic telomeres to the nuclear envelope PNAS, May 1, 2007; 104(18): 7426 - 7431. [Abstract] [Full Text] [PDF]

				X. Zhang, R. Xu, B. Zhu, X. Yang, X. Ding, S. Duan, T. Xu, Y. Zhuang, and M. Han Syne-1 and Syne-2 play crucial roles in myonuclear anchorage and motor neuron innervation Development, March 1, 2007; 134(5): 901 - 908. [Abstract] [Full Text] [PDF]

				I. M. Sehring, C. Reiner, J. Mansfeld, H. Plattner, and R. Kissmehl A broad spectrum of actin paralogs in Paramecium tetraurelia cells display differential localization and function J. Cell Sci., January 1, 2007; 120(1): 177 - 190. [Abstract] [Full Text] [PDF]

				K. Wilhelmsen, M. Ketema, H. Truong, and A. Sonnenberg KASH-domain proteins in nuclear migration, anchorage and other processes J. Cell Sci., December 15, 2006; 119(24): 5021 - 5029. [Abstract] [Full Text] [PDF]

				F. Haque, D. J. Lloyd, D. T. Smallwood, C. L. Dent, C. M. Shanahan, A. M. Fry, R. C. Trembath, and S. Shackleton SUN1 Interacts with Nuclear Lamin A and Cytoplasmic Nesprins To Provide a Physical Connection between the Nuclear Lamina and the Cytoskeleton Mol. Cell. Biol., May 15, 2006; 26(10): 3738 - 3751. [Abstract] [Full Text] [PDF]

				H. Masuda, R. Miyamoto, T. Haraguchi, and Y. Hiraoka The carboxy-terminus of Alp4 alters microtubule dynamics to induce oscillatory nuclear movement led by the spindle pole body in Schizosaccharomyces pombe Genes Cells, April 1, 2006; 11(4): 337 - 352. [Abstract] [Full Text] [PDF]

				M. D. McGee, R. Rillo, A. S. Anderson, and D. A. Starr UNC-83 Is a KASH Protein Required for Nuclear Migration and Is Recruited to the Outer Nuclear Membrane by a Physical Interaction with the SUN Protein UNC-84 Mol. Biol. Cell, April 1, 2006; 17(4): 1790 - 1801. [Abstract] [Full Text] [PDF]

				M. Crisp, Q. Liu, K. Roux, J.B. Rattner, C. Shanahan, B. Burke, P. D. Stahl, and D. Hodzic Coupling of the nucleus and cytoplasm: role of the LINC complex J. Cell Biol., January 3, 2006; 172(1): 41 - 53. [Abstract] [Full Text] [PDF]

				K. Wilhelmsen, S. H.M. Litjens, I. Kuikman, N. Tshimbalanga, H. Janssen, I. van den Bout, K. Raymond, and A. Sonnenberg Nesprin-3, a novel outer nuclear membrane protein, associates with the cytoskeletal linker protein plectin J. Cell Biol., December 5, 2005; 171(5): 799 - 810. [Abstract] [Full Text] [PDF]

				J. Lammerding, J. Hsiao, P. C. Schulze, S. Kozlov, C. L. Stewart, and R. T. Lee Abnormal nuclear shape and impaired mechanotransduction in emerin-deficient cells J. Cell Biol., August 29, 2005; 170(5): 781 - 791. [Abstract] [Full Text] [PDF]

				V.C. Padmakumar, T. Libotte, W. Lu, H. Zaim, S. Abraham, A. A. Noegel, J. Gotzmann, R. Foisner, and I. Karakesisoglou The inner nuclear membrane protein Sun1 mediates the anchorage of Nesprin-2 to the nuclear envelope J. Cell Sci., August 1, 2005; 118(15): 3419 - 3430. [Abstract] [Full Text] [PDF]

				L. C. Mounkes, S. V. Kozlov, J. N. Rottman, and C. L. Stewart Expression of an LMNA-N195K variant of A-type lamins results in cardiac conduction defects and death in mice Hum. Mol. Genet., August 1, 2005; 14(15): 2167 - 2180. [Abstract] [Full Text] [PDF]

				T. Libotte, H. Zaim, S. Abraham, V. C. Padmakumar, M. Schneider, W. Lu, M. Munck, C. Hutchison, M. Wehnert, B. Fahrenkrog, et al. Lamin A/C-dependent Localization of Nesprin-2, a Giant Scaffolder at the Nuclear Envelope Mol. Biol. Cell, July 1, 2005; 16(7): 3411 - 3424. [Abstract] [Full Text] [PDF]

				M. A. Ruegg Organization of synaptic myonuclei by Syne proteins and their role during the formation of the nerve-muscle synapse PNAS, April 19, 2005; 102(16): 5643 - 5644. [Full Text] [PDF]

				R. M. Grady, D. A. Starr, G. L. Ackerman, J. R. Sanes, and M. Han From the Cover: Syne proteins anchor muscle nuclei at the neuromuscular junction PNAS, March 22, 2005; 102(12): 4359 - 4364. [Abstract] [Full Text] [PDF]

				Y. Guo, S. Jangi, and M. A. Welte Organelle-specific Control of Intracellular Transport: Distinctly Targeted Isoforms of the Regulator Klar Mol. Biol. Cell, March 1, 2005; 16(3): 1406 - 1416. [Abstract] [Full Text] [PDF]

				D. R. Croft, M. L. Coleman, S. Li, D. Robertson, T. Sullivan, C. L. Stewart, and M. F. Olson Actin-myosin-based contraction is responsible for apoptotic nuclear disintegration J. Cell Biol., January 17, 2005; 168(2): 245 - 255. [Abstract] [Full Text] [PDF]

				R. Kissmehl, I. M. Sehring, E. Wagner, and H. Plattner Immunolocalization of Actin in Paramecium Cells J. Histochem. Cytochem., December 1, 2004; 52(12): 1543 - 1559. [Abstract] [Full Text] [PDF]

				J. Pouwels, T. van der Velden, J. Willemse, J. W. Borst, J. van Lent, T. Bisseling, and J. Wellink Studies on the origin and structure of tubules made by the movement protein of Cowpea mosaic virus J. Gen. Virol., December 1, 2004; 85(12): 3787 - 3796. [Abstract] [Full Text] [PDF]

				J. A. Fischer, S. Acosta, A. Kenny, C. Cater, C. Robinson, and J. Hook Drosophila Klarsicht Has Distinct Subcellular Localization Domains for Nuclear Envelope and Microtubule Localization in the Eye Genetics, November 1, 2004; 168(3): 1385 - 1393. [Abstract] [Full Text] [PDF]

				J. L. Whited, A. Cassell, M. Brouillette, and P. A. Garrity Dynactin is required to maintain nuclear position within postmitotic Drosophila photoreceptor neurons Development, October 1, 2004; 131(19): 4677 - 4686. [Abstract] [Full Text] [PDF]

				L. Gerace TorsinA and torsion dystonia: Unraveling the architecture of the nuclear envelope PNAS, June 15, 2004; 101(24): 8839 - 8840. [Full Text] [PDF]

				D. M. Hodzic, D. B. Yeater, L. Bengtsson, H. Otto, and P. D. Stahl Sun2 Is a Novel Mammalian Inner Nuclear Membrane Protein J. Biol. Chem., June 11, 2004; 279(24): 25805 - 25812. [Abstract] [Full Text] [PDF]

				A. Fridkin, E. Mills, A. Margalit, E. Neufeld, K. K. Lee, N. Feinstein, M. Cohen, K. L. Wilson, and Y. Gruenbaum Matefin, a Caenorhabditis elegans germ line-specific SUN-domain nuclear membrane protein, is essential for early embryonic and germ cell development PNAS, May 4, 2004; 101(18): 6987 - 6992. [Abstract] [Full Text] [PDF]

				N. Wagner, D. Weber, S. Seitz, and G. Krohne The lamin B receptor of Drosophila melanogaster J. Cell Sci., April 15, 2004; 117(10): 2015 - 2028. [Abstract] [Full Text] [PDF]

				K.-H. Kuo and C. Y. Seow Contractile filament architecture and force transmission in swine airway smooth muscle J. Cell Sci., March 15, 2004; 117(8): 1503 - 1511. [Abstract] [Full Text] [PDF]

				M. S. Zastrow, S. Vlcek, and K. L. Wilson Proteins that bind A-type lamins: integrating isolated clues J. Cell Sci., March 1, 2004; 117(7): 979 - 987. [Abstract] [Full Text] [PDF]

				K. Patterson, A. B. Molofsky, C. Robinson, S. Acosta, C. Cater, and J. A. Fischer The Functions of Klarsicht and Nuclear Lamin in Developmentally Regulated Nuclear Migrations of Photoreceptor Cells in the Drosophila Eye Mol. Biol. Cell, February 1, 2004; 15(2): 600 - 610. [Abstract] [Full Text] [PDF]