|
|
|
|
|
|
|
|
|||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | |||||
First published online November 3, 2003
doi: 10.1242/10.1242/jcs.00840
Commentary |
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
(e-mail: ben{at}mrc-lmb.cam.ac.uk)
Endocytosis of various endogenous plasma membrane molecules, including signalling receptors, glycosphingolipids and glycosylphosphatidylinositol (GPI)-linked proteins, occurs in the absence of functional clathrin-coated pits. Most of these molecules are found in biochemically defined lipid rafts, which suggests that at least some clathrin-independent endocytosis may be raft specific or raft mediated. However, recent studies of the uptake of raft markers have revealed a diversity of internalization methods. Although lipid rafts may somehow be recognized by endocytic machinery, at this stage the data do not readily fit with the idea of a single raft-specific or raft-dependent endocytic pathway. Many studies report uptake of raft molecules by caveolar endocytosis (defined by sensitivity to cholesterol depletion and to overexpression of a specific mutant of dynamin 2). It is now apparent that this is a highly regulated process, and caveolin 1, one of the characteristic protein components of caveolae, might in fact act to slow or inhibit endocytosis. The molecular details of caveolar endocytosis have yet to be elucidated. Several sources indicate that clathrin-independent uptake to a distinct class of caveolin-1-containing endosome, termed the caveosome, allows different types of endocytic mechanisms to have different functional consequences for the cell. It is likely that there are mechanisms that allow recruitment and targeting of specific molecules to caveosomes.
Key words: Caveosome, Endocytosis, Lipid raft
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  S. M. Stamatovic, R. F. Keep, M. M. Wang, I. Jankovic, and A. V. Andjelkovic Caveolae-mediated Internalization of Occludin and Claudin-5 during CCL2-induced Tight Junction Remodeling in Brain Endothelial Cells J. Biol. Chem., July 10, 2009; 284(28): 19053 - 19066. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. L. Schnabl, M. Larcelet, A. B. R. Thomson, and M. T. Clandinin Uptake and fate of ganglioside GD3 in human intestinal Caco-2 cells Am J Physiol Gastrointest Liver Physiol, July 1, 2009; 297(1): G52 - G59. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. W. Zhang and N. A. Monteiro-Riviere Mechanisms of Quantum Dot Nanoparticle Cellular Uptake Toxicol. Sci., July 1, 2009; 110(1): 138 - 155. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Masuyama, T. Kuronita, R. Tanaka, T. Muto, Y. Hirota, A. Takigawa, H. Fujita, Y. Aso, J. Amano, and Y. Tanaka HM1.24 Is Internalized from Lipid Rafts by Clathrin-mediated Endocytosis through Interaction with {alpha}-Adaptin J. Biol. Chem., June 5, 2009; 284(23): 15927 - 15941. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. G. Hansen and B. J. Nichols Molecular mechanisms of clathrin-independent endocytosis J. Cell Sci., June 1, 2009; 122(11): 1713 - 1721. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Mandrekar, Q. Jiang, C. Y. D. Lee, J. Koenigsknecht-Talboo, D. M. Holtzman, and G. E. Landreth Microglia Mediate the Clearance of Soluble A{beta} through Fluid Phase Macropinocytosis J. Neurosci., April 1, 2009; 29(13): 4252 - 4262. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Parker, D. S. Walker, S. Ly, and H. A. Baylis Caveolin-2 Is Required for Apical Lipid Trafficking and Suppresses Basolateral Recycling Defects in the Intestine of Caenorhabditis elegans Mol. Biol. Cell, March 15, 2009; 20(6): 1763 - 1771. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. Bantel-Schaal, I. Braspenning-Wesch, and J. Kartenbeck Adeno-associated virus type 5 exploits two different entry pathways in human embryo fibroblasts J. Gen. Virol., February 1, 2009; 90(2): 317 - 322. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Okada, E. Yamada, T. Saito, K. Ohshima, K. Hashimoto, M. Yamada, Y. Uehara, T. Tsuchiya, H. Shimizu, K. Tatei, et al. CDK5-dependent Phosphorylation of the Rho Family GTPase TC10{alpha} Regulates Insulin-stimulated GLUT4 Translocation J. Biol. Chem., December 19, 2008; 283(51): 35455 - 35463. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. H. Weiss, J. Carbajo Lozoya, S. Tuma, D. Gotthardt, J. Reichert, R. Ehehalt, W. Stremmel, and J. Fullekrug Copper-Induced Translocation of the Wilson Disease Protein ATP7B Independent of Murr1/COMMD1 and Rab7 Am. J. Pathol., December 1, 2008; 173(6): 1783 - 1794. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Cai, H. Wang, Y. Chen, L. Liu, W. T Gunning, L. E. M. Quintas, and Z.-J. Xie Regulation of caveolin-1 membrane trafficking by the Na/K-ATPase J. Cell Biol., September 22, 2008; 182(6): 1153 - 1169. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Pietrella, P. Lupo, A. Rachini, S. Sandini, A. Ciervo, S. Perito, F. Bistoni, and A. Vecchiarelli A Candida albicans Mannoprotein Deprived of Its Mannan Moiety Is Efficiently Taken Up and Processed by Human Dendritic Cells and Induces T-Cell Activation without Stimulating Proinflammatory Cytokine Production Infect. Immun., September 1, 2008; 76(9): 4359 - 4367. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Delva, J. M. Jennings, C. C. Calkins, M. D. Kottke, V. Faundez, and A. P. Kowalczyk Pemphigus Vulgaris IgG-induced Desmoglein-3 Endocytosis and Desmosomal Disassembly Are Mediated by a Clathrin- and Dynamin-independent Mechanism J. Biol. Chem., June 27, 2008; 283(26): 18303 - 18313. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Hernandez-Deviez, M. T. Howes, S. H. Laval, K. Bushby, J. F. Hancock, and R. G. Parton Caveolin Regulates Endocytosis of the Muscle Repair Protein, Dysferlin J. Biol. Chem., March 7, 2008; 283(10): 6476 - 6488. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Nohe and N. O. Petersen Image Correlation Spectroscopy Sci. Signal., December 18, 2007; 2007(417): pl7 - pl7. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. I. Gonzalez, E. Krizman-Genda, and M. B. Robinson Caveolin-1 Regulates the Delivery and Endocytosis of the Glutamate Transporter, Excitatory Amino Acid Carrier 1 J. Biol. Chem., October 12, 2007; 282(41): 29855 - 29865. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. P. Atshaves, A. L. McIntosh, H. R. Payne, A. M. Gallegos, K. Landrock, N. Maeda, A. B. Kier, and F. Schroeder SCP-2/SCP-x gene ablation alters lipid raft domains in primary cultured mouse hepatocytes J. Lipid Res., October 1, 2007; 48(10): 2193 - 2211. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. N. Atapattu and C. J. Czuprynski Mannheimia haemolytica Leukotoxin Binds to Lipid Rafts in Bovine Lymphoblastoid Cells and Is Internalized in a Dynamin-2- and Clathrin-Dependent Manner Infect. Immun., October 1, 2007; 75(10): 4719 - 4727. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Moriyama, J. P. Marquez, T. Wakatsuki, and A. Sorokin Caveolar Endocytosis Is Critical for BK Virus Infection of Human Renal Proximal Tubular Epithelial Cells J. Virol., August 15, 2007; 81(16): 8552 - 8562. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Shiokawa, T. Matsushita, Y. Shika, M. Shimizu, M. Maeda, and S.-i. Tanuma DNase X Is a Glycosylphosphatidylinositol-anchored Membrane Enzyme That Provides a Barrier to Endocytosis-mediated Transfer of a Foreign Gene J. Biol. Chem., June 8, 2007; 282(23): 17132 - 17140. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. G. Martinez, S. M. Cordo, and N. A. Candurra Characterization of Junin arenavirus cell entry J. Gen. Virol., June 1, 2007; 88(6): 1776 - 1784. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Pizzato, A. Helander, E. Popova, A. Calistri, A. Zamborlini, G. Palu, and H. G. Gottlinger Dynamin 2 is required for the enhancement of HIV-1 infectivity by Nef PNAS, April 17, 2007; 104(16): 6812 - 6817. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Michihara, K. Toda, M. Suenobu, K. Akasaki, and H. Tsuji Decrease of Cholesterol in Mouse Melanoma Causes Secretion of Lysosomal Enzymes J. Biochem., February 1, 2007; 141(2): 239 - 250. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. M. Mutch, R. Sanyal, T. L. Unruh, L. Grigoriou, M. Zhu, W. Zhang, and J. P. Deans Activation-induced endocytosis of the raft-associated transmembrane adaptor protein LAB/NTAL in B lymphocytes: evidence for a role in internalization of the B cell receptor Int. Immunol., January 1, 2007; 19(1): 19 - 30. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Mani, F. Cheng, and L.-A. Fransson Constitutive and vitamin C-induced, NO-catalyzed release of heparan sulfate from recycling glypican-1 in late endosomes Glycobiology, December 1, 2006; 16(12): 1251 - 1261. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Liu and A. Askari beta-Subunit of cardiac Na+-K+-ATPase dictates the concentration of the functional enzyme in caveolae Am J Physiol Cell Physiol, October 1, 2006; 291(4): C569 - C578. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Mani, F. Cheng, and L.-A. Fransson Defective nitric oxide-dependent, deaminative cleavage of glypican-1 heparan sulfate in Niemann-Pick C1 fibroblasts Glycobiology, August 1, 2006; 16(8): 711 - 718. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. T. Browman, M. E. Resek, L. D. Zajchowski, and S. M. Robbins Erlin-1 and erlin-2 are novel members of the prohibitin family of proteins that define lipid-raft-like domains of the ER J. Cell Sci., August 1, 2006; 119(15): 3149 - 3160. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Blanchard, S. Belouzard, L. Goueslain, T. Wakita, J. Dubuisson, C. Wychowski, and Y. Rouille Hepatitis C Virus Entry Depends on Clathrin-Mediated Endocytosis J. Virol., July 15, 2006; 80(14): 6964 - 6972. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Garcion, A. Lamprecht, B. Heurtault, A. Paillard, A. Aubert-Pouessel, B. Denizot, P. Menei, and J.-P. Benoit A new generation of anticancer, drug-loaded, colloidal vectors reverses multidrug resistance in glioma and reduces tumor progression in rats. Mol. Cancer Ther., July 1, 2006; 5(7): 1710 - 1722. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. M. Smith, A. Nesterova, S. C. Alley, M. Y. Torgov, and P. J. Carter Potent cytotoxicity of an auristatin-containing antibody-drug conjugate targeting melanoma cells expressing melanotransferrin/p97. Mol. Cancer Ther., June 1, 2006; 5(6): 1474 - 1482. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Lugini, P. Matarrese, A. Tinari, F. Lozupone, C. Federici, E. Iessi, M. Gentile, F. Luciani, G. Parmiani, L. Rivoltini, et al. Cannibalism of live lymphocytes by human metastatic but not primary melanoma cells. Cancer Res., April 1, 2006; 66(7): 3629 - 3638. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. C.-H. Chen, P. J. Schweinsberg, S. Vashist, D. P. Mareiniss, E. J. Lambie, and B. D. Grant RAB-10 Is Required for Endocytic Recycling in the Caenorhabditis elegans Intestine Mol. Biol. Cell, March 1, 2006; 17(3): 1286 - 1297. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Orlichenko, B. Huang, E. Krueger, and M. A. McNiven Epithelial Growth Factor-induced Phosphorylation of Caveolin 1 at Tyrosine 14 Stimulates Caveolae Formation in Epithelial Cells J. Biol. Chem., February 24, 2006; 281(8): 4570 - 4579. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Sachdev, R. Singh, Y. Fujita-Yamaguchi, and D. Yee Down-regulation of Insulin Receptor by Antibodies against the Type I Insulin-Like Growth Factor Receptor: Implications for Anti-Insulin-Like Growth Factor Therapy in Breast Cancer Cancer Res., February 15, 2006; 66(4): 2391 - 2402. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Kasai, T. Shima, and M. Okada Role of Src family tyrosine kinases in the down-regulation of epidermal growth factor signaling in PC12 cells Genes Cells, December 1, 2005; 10(12): 1175 - 1187. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Schwarz-Romond, C. Merrifield, B. J. Nichols, and M. Bienz The Wnt signalling effector Dishevelled forms dynamic protein assemblies rather than stable associations with cytoplasmic vesicles J. Cell Sci., November 15, 2005; 118(22): 5269 - 5277. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. M. Urs, K. T. Jones, P. D. Salo, J. E. Severin, J. Trejo, and H. Radhakrishna A requirement for membrane cholesterol in the {beta}-arrestin- and clathrin-dependent endocytosis of LPA1 lysophosphatidic acid receptors J. Cell Sci., November 15, 2005; 118(22): 5291 - 5304. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Freche, P. Guillaumot, J. Charmetant, L. Pelletier, C. Luquain, D. Christiansen, M. Billaud, and S. N. Manie Inducible Dimerization of RET Reveals a Specific AKT Deregulation in Oncogenic Signaling J. Biol. Chem., November 4, 2005; 280(44): 36584 - 36591. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. R. Taylor, N. T. Watt, W. S. S. Perera, and N. M. Hooper Assigning functions to distinct regions of the N-terminus of the prion protein that are involved in its copper-stimulated, clathrin-dependent endocytosis J. Cell Sci., November 1, 2005; 118(21): 5141 - 5153. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-X. Zhu, S. Goldoni, G. Bix, R. T. Owens, D. J. McQuillan, C. C. Reed, and R. V. Iozzo Decorin Evokes Protracted Internalization and Degradation of the Epidermal Growth Factor Receptor via Caveolar Endocytosis J. Biol. Chem., September 16, 2005; 280(37): 32468 - 32479. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Marchant, S. J. D. Neil, K. Aubin, C. Schmitz, and A. McKnight An Envelope-Determined, pH-Independent Endocytic Route of Viral Entry Determines the Susceptibility of Human Immunodeficiency Virus Type 1 (HIV-1) and HIV-2 to Lv2 Restriction J. Virol., August 1, 2005; 79(15): 9410 - 9418. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Gaus, M. Rodriguez, K. R. Ruberu, I. Gelissen, T. M. Sloane, L. Kritharides, and W. Jessup Domain-specific lipid distribution in macrophage plasma membranes J. Lipid Res., July 1, 2005; 46(7): 1526 - 1538. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Allen, J. Z. Yu, R. J. Donati, and M. M. Rasenick {beta}-Adrenergic Receptor Stimulation Promotes G{alpha}s Internalization through Lipid Rafts: A Study in Living Cells Mol. Pharmacol., May 1, 2005; 67(5): 1493 - 1504. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Pol, S. Martin, M. A. Fernandez, M. Ingelmo-Torres, C. Ferguson, C. Enrich, and R. G. Parton Cholesterol and Fatty Acids Regulate Dynamic Caveolin Trafficking through the Golgi Complex and between the Cell Surface and Lipid Bodies Mol. Biol. Cell, April 1, 2005; 16(4): 2091 - 2105. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Monastyrskaya, A. Hostettler, S. Buergi, and A. Draeger The NK1 Receptor Localizes to the Plasma Membrane Microdomains, and Its Activation Is Dependent on Lipid Raft Integrity J. Biol. Chem., February 25, 2005; 280(8): 7135 - 7146. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. W. Zaas, M. J. Duncan, G. Li, J. R. Wright, and S. N. Abraham Pseudomonas Invasion of Type I Pneumocytes Is Dependent on the Expression and Phosphorylation of Caveolin-2 J. Biol. Chem., February 11, 2005; 280(6): 4864 - 4872. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Signoret, L. Hewlett, S. Wavre, A. Pelchen-Matthews, M. Oppermann, and M. Marsh Agonist-induced Endocytosis of CC Chemokine Receptor 5 Is Clathrin Dependent Mol. Biol. Cell, February 1, 2005; 16(2): 902 - 917. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E.-M. Damm, L. Pelkmans, J. Kartenbeck, A. Mezzacasa, T. Kurzchalia, and A. Helenius Clathrin- and caveolin-1-independent endocytosis: entry of simian virus 40 into cells devoid of caveolae J. Cell Biol., January 31, 2005; 168(3): 477 - 488. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Sauvonnet, A. Dujeancourt, and A. Dautry-Varsat Cortactin and dynamin are required for the clathrin-independent endocytosis of {gamma}c cytokine receptor J. Cell Biol., January 3, 2005; 168(1): 155 - 163. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Cocucci, G. Racchetti, P. Podini, M. Rupnik, and J. Meldolesi Enlargeosome, an Exocytic Vesicle Resistant to Nonionic Detergents, Undergoes Endocytosis via a Nonacidic Route Mol. Biol. Cell, December 1, 2004; 15(12): 5356 - 5368. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Sandgren, A. Wittrup, F. Cheng, M. Jonsson, E. Eklund, S. Busch, and M. Belting The Human Antimicrobial Peptide LL-37 Transfers Extracellular DNA Plasmid to the Nuclear Compartment of Mammalian Cells via Lipid Rafts and Proteoglycan-dependent Endocytosis J. Biol. Chem., April 23, 2004; 279(17): 17951 - 17956. [Abstract] [Full Text] [PDF]
|
|
