|
|
|
|
|
|
|
|
|||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | |||||
First published online November 18, 2003
doi: 10.1242/10.1242/jcs.00872
Commentary |
point the way
1 Center for Molecular Medicine, Maine Medical Center Research Institute, 81 Research Drive, Scarborough, Maine 04074, USA
2 Department of Oncology, Catholic University of Rome, School of Medicine, Rome 00168, Italy
3 Department of Geriatric Medicine, University of Florence, School of Medicine, Florence 50139, Italy
* Author for correspondence (e-mail: maciat{at}mmc.org)
Non-classical protein release independent of the ER-Golgi pathway has been reported for an increasing number of proteins lacking an N-terminal signal sequence. The export of FGF1 and IL-1
, two pro-angiogenic polypeptides, provides two such examples. In both cases, export is based on the Cu2+-dependent formation of multiprotein complexes containing the S100A13 protein and might involve translocation of the protein across the membrane as a `molten globule'. FGF1 and IL-1 are involved in pathological processes such as restenosis and tumor formation. Inhibition of their export by Cu2+ chelators is thus an effective strategy for treatment of several diseases.
Key words: Fibroblast growth factor 1, FGF1, Interleukin 1, IL-1, Release, Non-classical, Copper, Synaptotagmin 1, S100A13
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  L. C. Torrado, K. Temmerman, H.-M. Muller, M. P. Mayer, C. Seelenmeyer, R. Backhaus, and W. Nickel An intrinsic quality-control mechanism ensures unconventional secretion of fibroblast growth factor 2 in a folded conformation J. Cell Sci., September 15, 2009; 122(18): 3322 - 3329. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Lu, J. Ito, N. Iwamoto, T. Nishimaki-Mogami, and S. Yokoyama FGF-1 induces expression of LXR{alpha} and production of 25-hydroxycholesterol to upregulate the apoE gene in rat astrocytes J. Lipid Res., June 1, 2009; 50(6): 1156 - 1164. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. S. Chen, C. M. Nelson, D. Khauv, S. Bennett, E. S. Radisky, Y. Hirai, M. J. Bissell, and D. C. Radisky Homology with Vesicle Fusion Mediator Syntaxin-1a Predicts Determinants of Epimorphin/Syntaxin-2 Function in Mammary Epithelial Morphogenesis J. Biol. Chem., March 13, 2009; 284(11): 6877 - 6884. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. J. Mintz, M. Cardo-Vila, M. G. Ozawa, A. Hajitou, R. Rangel, L. Guzman-Rojas, D. R. Christianson, M. A. Arap, R. J. Giordano, G. R. Souza, et al. An unrecognized extracellular function for an intracellular adapter protein released from the cytoplasm into the tumor microenvironment PNAS, February 17, 2009; 106(7): 2182 - 2187. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Duarte, V. Kolev, D. Kacer, C. Mouta-Bellum, R. Soldi, I. Graziani, A. Kirov, R. Friesel, L. Liaw, D. Small, et al. Novel Cross-Talk between Three Cardiovascular Regulators: Thrombin Cleavage Fragment of Jagged1 Induces Fibroblast Growth Factor 1 Expression and Release Mol. Biol. Cell, November 1, 2008; 19(11): 4863 - 4874. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. L. Chaffin Candida albicans Cell Wall Proteins Microbiol. Mol. Biol. Rev., September 1, 2008; 72(3): 495 - 544. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Nickel Unconventional secretion: an extracellular trap for export of fibroblast growth factor 2 J. Cell Sci., July 15, 2007; 120(14): 2295 - 2299. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Hirai, C. M. Nelson, K. Yamazaki, K. Takebe, J. Przybylo, B. Madden, and D. C. Radisky Non-classical export of epimorphin and its adhesion to {alpha}v-integrin in regulation of epithelial morphogenesis J. Cell Sci., June 15, 2007; 120(12): 2032 - 2043. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. S. Mambula and S. K. Calderwood Heat Shock Protein 70 Is Secreted from Tumor Cells by a Nonclassical Pathway Involving Lysosomal Endosomes J. Immunol., December 1, 2006; 177(11): 7849 - 7857. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Zehe, A. Engling, S. Wegehingel, T. Schafer, and W. Nickel Cell-surface heparan sulfate proteoglycans are essential components of the unconventional export machinery of FGF-2 PNAS, October 17, 2006; 103(42): 15479 - 15484. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Lynes, K. Zaffuto, D. W. Unfricht, G. Marusov, J. S. Samson, and X. Yin The physiological roles of extracellular metallothionein. Experimental Biology and Medicine, October 1, 2006; 231(9): 1548 - 1554. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Omer, D. Meredith, J. F. Morris, and H. C. Christian Evidence for the Role of Adenosine 5'-Triphosphate-Binding Cassette (ABC)-A1 in the Externalization of Annexin 1 from Pituitary Folliculostellate Cells and ABCA1-Transfected Cell Models Endocrinology, July 1, 2006; 147(7): 3219 - 3227. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Thomas, K. Jordan, J. Simek, Q. Shao, C. Jedeszko, P. Walton, and D. W. Laird Mechanisms of Cx43 and Cx26 transport to the plasma membrane and gap junction regeneration J. Cell Sci., October 1, 2005; 118(19): 4451 - 4462. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Stegmayer, A. Kehlenbach, S. Tournaviti, S. Wegehingel, C. Zehe, P. Denny, D. F. Smith, B. Schwappach, and W. Nickel Direct transport across the plasma membrane of mammalian cells of Leishmania HASPB as revealed by a CHO export mutant J. Cell Sci., February 1, 2005; 118(3): 517 - 527. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Wiedlocha, T. Nilsen, J. Wesche, V. Sorensen, J. Malecki, E. Marcinkowska, and S. Olsnes Phosphorylation-regulated Nucleocytoplasmic Trafficking of Internalized Fibroblast Growth Factor-1 Mol. Biol. Cell, February 1, 2005; 16(2): 794 - 810. [Abstract] [Full Text] [PDF]
|
|
