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doi: 10.1242/10.1242/jcs.00249

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Journal of Cell Science 116, 441-445 (2003)
doi: 10.1242/jcs.00249

Hypothesis

Sexy splicing: regulatory interplays governing sex determination from Drosophila to mammals

Enzo Lalli1,*, Kenji Ohe1, Elisa Latorre2, Marco E. Bianchi2 and Paolo Sassone-Corsi1,*

1 Institut de Génétique et de Biologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Université Louis Pasteur, B.P. 163, 67404 Illkirch, Strasbourg, France
2 Università San Raffaele, Via Olgettina 58, 20132 Milano, Italy

* Authors for correspondence (e-mail: ninino{at}igbmc.u-strasbg.fr; paolosc{at}igbmc.u-strasbg.fr)

A remarkable array of strategies is used to produce sexual differentiation in different species. Complex gene hierarchies govern sex determination pathways, as exemplified by the classic D. melanogaster paradigm, where an interplay of transcriptional, splicing and translational mechanisms operate. Molecular studies support the hypothesis that genetic sex determination pathways evolved in reverse order, from downstream to upstream genes, in the cascade. The recent identification of a role for the key regulatory factors SRY and WT1(+KTS) in pre-mRNA splicing indicates that important steps in the mammalian sex determination process are likely to operate at the post-transcriptional level.

Key words: Sex determination, Splicing factors, Developmental pathways, Sox factor


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