QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

doi: 10.1242/10.1242/jcs.00310

This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by González-Reyes, A. Search for Related Content PubMed PubMed Citation Articles by González-Reyes, A.

Stem cells, niches and cadherins: a view from Drosophila

Instituto de Parasitología y Biomedicina-CSIC, C/Ventanilla 11, 18001 Granada, Spain

e-mail: agr{at}ipb.csic.es

Stem cells are essential for the correct development and homeostasis of adult organisms, as well as having obvious potential therapeutic importance. Analysis of the biology of stem cells and their regulatory microenvironment in adult organs has, however, been hindered by the rarity of these cells in mature tissues and by the lack of positive markers for them. The ovary of the Drosophila melanogaster female is a stem cell niche in which such analyses can be performed. The stromal cells of the microenvironment act as a regulatory centre to control the proliferation and differentiation of the germline stem cells, using several signalling molecules, among them the protein DPP – a Drosophila homologue of the human bone morphogenetic proteins BMP2 and BMP4. Recent work shows that DE-cadherin-mediated adhesion is used for the initial recruitment and posterior anchoring of the germline-derived stem cells in their niche.

Key words: Stem cells, DE cadherin, germline, Drosophila

Related articles in JCS:

Modelling stem cell niches

JCS 2003 116: 601. [Full Text]  

This article has been cited by other articles:

				L. Lopez-Onieva, A. Fernandez-Minan, and A. Gonzalez-Reyes Jak/Stat signalling in niche support cells regulates dpp transcription to control germline stem cell maintenance in the Drosophila ovary Development, February 1, 2008; 135(3): 533 - 540. [Abstract] [Full Text] [PDF]

				J. A. Martinez-Agosto, H. K.A. Mikkola, V. Hartenstein, and U. Banerjee The hematopoietic stem cell and its niche: a comparative view Genes & Dev., December 1, 2007; 21(23): 3044 - 3060. [Abstract] [Full Text] [PDF]

				T. Oyama, T. Nagai, H. Wada, A. T. Naito, K. Matsuura, K. Iwanaga, T. Takahashi, M. Goto, Y. Mikami, N. Yasuda, et al. Cardiac side population cells have a potential to migrate and differentiate into cardiomyocytes in vitro and in vivo J. Cell Biol., January 29, 2007; 176(3): 329 - 341. [Abstract] [Full Text] [PDF]

				A. Leri, J. Kajstura, and P. Anversa Cardiac Stem Cells and Mechanisms of Myocardial Regeneration Physiol Rev, October 1, 2005; 85(4): 1373 - 1416. [Abstract] [Full Text] [PDF]

				A. Klebes, A. Sustar, K. Kechris, H. Li, G. Schubiger, and T. B. Kornberg Regulation of cellular plasticity in Drosophila imaginal disc cells by the Polycomb group, trithorax group and lama genes Development, August 15, 2005; 132(16): 3753 - 3765. [Abstract] [Full Text] [PDF]

				R. Benetti, T. Copetti, S. Dell'Orso, E. Melloni, C. Brancolini, M. Monte, and C. Schneider The Calpain System Is Involved in the Constitutive Regulation of {beta}-Catenin Signaling Functions J. Biol. Chem., June 10, 2005; 280(23): 22070 - 22080. [Abstract] [Full Text] [PDF]

				Y. M. Yamashita, M. T. Fuller, and D. L. Jones Signaling in stem cell niches: lessons from the Drosophila germline J. Cell Sci., February 15, 2005; 118(4): 665 - 672. [Abstract] [Full Text] [PDF]

				W. J. Nelson and R. Nusse Convergence of Wnt, {beta}-Catenin, and Cadherin Pathways Science, March 5, 2004; 303(5663): 1483 - 1487. [Abstract] [Full Text] [PDF]