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doi: 10.1242/10.1242/jcs.00373


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Journal of Cell Science 116, 1409-1416 (2003)
doi: 10.1242/jcs.00373


Commentary

Focal adhesion kinase: the first ten years

J. Thomas Parsons

Department of Microbiology, Box 800734, University of Virginia Health System, Charlottesville, VA 22908, USA

e-mail: jtp{at}virginia.edu

The protein tyrosine kinase focal adhesion kinase (FAK) plays a prominent role in integrin signaling. FAK activation, demonstrated by an increase in phosphorylation of Tyr397 as well as other sites in the protein, is best understood in the context of the engagement of integrins at the cell surface. Activation of FAK results in recruitment of a number of SH2-domain- and SH3-domain-containing proteins, which mediate signaling to several downstream pathways. FAK-dependent activation of these pathways has been implicated in a diverse array of cellular processes, including cell migration, growth factor signaling, cell cycle progression and cell survival.

Key words: Kinase, Focal Adhesion, Migration, Cytoskeleton




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[Abstract] [Full Text] [PDF]


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Home page
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[Abstract] [Full Text] [PDF]


Home page
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Home page
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[Abstract] [Full Text] [PDF]


Home page
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Sci. Signal., March 13, 2007; 2007(377): pe10 - pe10.
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Home page
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[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
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J. Virol., February 1, 2007; 81(3): 1209 - 1219.
[Abstract] [Full Text] [PDF]


Home page
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J. H. Lorch, T. O. Thomas, and H.-J. Schmoll
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Cancer Res., January 15, 2007; 67(2): 727 - 734.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
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Am J Physiol Lung Cell Mol Physiol, January 1, 2007; 292(1): L334 - L342.
[Abstract] [Full Text] [PDF]


Home page
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M. Takeji, T. Moriyama, S. Oseto, N. Kawada, M. Hori, E. Imai, and T. Miwa
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J. Biol. Chem., December 29, 2006; 281(52): 40193 - 40200.
[Abstract] [Full Text] [PDF]


Home page
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[Abstract] [Full Text] [PDF]


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Home page
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[Abstract] [Full Text] [PDF]


Home page
Circ. Res.Home page
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Carcinogenesis, September 1, 2006; 27(9): 1748 - 1757.
[Abstract] [Full Text] [PDF]


Home page
J. Cell Sci.Home page
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Home page
Mol. Biol. CellHome page
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Mol. Biol. Cell, August 1, 2006; 17(8): 3508 - 3520.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
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J. Biol. Chem., July 14, 2006; 281(28): 19631 - 19644.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. Biol.Home page
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Mol. Cell. Biol., July 1, 2006; 26(13): 5155 - 5167.
[Abstract] [Full Text] [PDF]


Home page
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Home page
J. Biol. Chem.Home page
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