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doi: 10.1242/10.1242/jcs.00373
Commentary |
Department of Microbiology, Box 800734, University of Virginia Health System, Charlottesville, VA 22908, USA
e-mail: jtp{at}virginia.edu
The protein tyrosine kinase focal adhesion kinase (FAK) plays a prominent role in integrin signaling. FAK activation, demonstrated by an increase in phosphorylation of Tyr397 as well as other sites in the protein, is best understood in the context of the engagement of integrins at the cell surface. Activation of FAK results in recruitment of a number of SH2-domain- and SH3-domain-containing proteins, which mediate signaling to several downstream pathways. FAK-dependent activation of these pathways has been implicated in a diverse array of cellular processes, including cell migration, growth factor signaling, cell cycle progression and cell survival.
Key words: Kinase, Focal Adhesion, Migration, Cytoskeleton
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M. Ozaki, H. Ogita, and Y. Takai Involvement of integrin-induced activation of protein kinase C in the formation of adherens junctions Genes Cells, May 1, 2007; 12(5): 651 - 662. [Abstract] [Full Text] [PDF]
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S. Murakami, D. Umetsu, Y. Maeyama, M. Sato, S. Yoshida, and T. Tabata Focal adhesion kinase controls morphogenesis of the Drosophila optic stalk Development, April 15, 2007; 134(8): 1539 - 1548. [Abstract] [Full Text] [PDF]
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W. T. Gerthoffer Mechanisms of Vascular Smooth Muscle Cell Migration Circ. Res., March 16, 2007; 100(5): 607 - 621. [Abstract] [Full Text] [PDF]
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 Y.-l. Wang Flux at Focal Adhesions: Slippage Clutch, Mechanical Gauge, or Signal Depot Sci. Signal., March 13, 2007; 2007(377): pe10 - pe10. [Abstract] [Full Text] [PDF]
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 K. M. Bourzac, C. M. Botham, and K. Guillemin Helicobacter pylori CagA Induces AGS Cell Elongation through a Cell Retraction Defect That Is Independent of Cdc42, Rac1, and Arp2/3 Infect. Immun., March 1, 2007; 75(3): 1203 - 1213. [Abstract] [Full Text] [PDF]
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 A. J. Pruijssers and M. R. Strand PTP-H2 and PTP-H3 from Microplitis demolitor Bracovirus Localize to Focal Adhesions and Are Antiphagocytic in Insect Immune Cells J. Virol., February 1, 2007; 81(3): 1209 - 1219. [Abstract] [Full Text] [PDF]
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J. H. Lorch, T. O. Thomas, and H.-J. Schmoll Bortezomib Inhibits Cell-Cell Adhesion and Cell Migration and Enhances Epidermal Growth Factor Receptor Inhibitor-Induced Cell Death in Squamous Cell Cancer Cancer Res., January 15, 2007; 67(2): 727 - 734. [Abstract] [Full Text] [PDF]
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 S. K. Quadri and J. Bhattacharya Resealing of endothelial junctions by focal adhesion kinase Am J Physiol Lung Cell Mol Physiol, January 1, 2007; 292(1): L334 - L342. [Abstract] [Full Text] [PDF]
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M. Takeji, T. Moriyama, S. Oseto, N. Kawada, M. Hori, E. Imai, and T. Miwa Smooth Muscle {alpha}-Actin Deficiency in Myofibroblasts Leads to Enhanced Renal Tissue Fibrosis J. Biol. Chem., December 29, 2006; 281(52): 40193 - 40200. [Abstract] [Full Text] [PDF]
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Y. Zhao, S. Itoh, X. Wang, T. Isaji, E. Miyoshi, Y. Kariya, K. Miyazaki, N. Kawasaki, N. Taniguchi, and J. Gu Deletion of Core Fucosylation on {alpha}3beta1 Integrin Down-regulates Its Functions J. Biol. Chem., December 15, 2006; 281(50): 38343 - 38350. [Abstract] [Full Text] [PDF]
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M. Kurayoshi, N. Oue, H. Yamamoto, M. Kishida, A. Inoue, T. Asahara, W. Yasui, and A. Kikuchi Expression of Wnt-5a Is Correlated with Aggressiveness of Gastric Cancer by Stimulating Cell Migration and Invasion Cancer Res., November 1, 2006; 66(21): 10439 - 10448. [Abstract] [Full Text] [PDF]
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 H. Xu, L. Zeng, H. Peng, S. Chen, J. Jones, T.-L. Chew, M. M. Sadeghi, Y. S. Kanwar, and F. R. Danesh HMG-CoA reductase inhibitor simvastatin mitigates VEGF-induced "inside-out" signaling to extracellular matrix by preventing RhoA activation Am J Physiol Renal Physiol, November 1, 2006; 291(5): F995 - F1004. [Abstract] [Full Text] [PDF]
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J. Shi and J. E. Casanova Invasion of Host Cells by Salmonella typhimurium Requires Focal Adhesion Kinase and p130Cas Mol. Biol. Cell, November 1, 2006; 17(11): 4698 - 4708. [Abstract] [Full Text] [PDF]
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K. Yokouchi, Y. Numaguchi, R. Kubota, M. Ishii, H. Imai, R. Murakami, Y. Ogawa, T. Kondo, K. Okumura, D. E. Ingber, et al. l-Caldesmon Regulates Proliferation and Migration of Vascular Smooth Muscle Cells and Inhibits Neointimal Formation After Angioplasty Arterioscler Thromb Vasc Biol, October 1, 2006; 26(10): 2231 - 2237. [Abstract] [Full Text] [PDF]
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L. A. DiMichele, J. T. Doherty, M. Rojas, H. E. Beggs, L. F. Reichardt, C. P. Mack, and J. M. Taylor Myocyte-Restricted Focal Adhesion Kinase Deletion Attenuates Pressure Overload-Induced Hypertrophy Circ. Res., September 15, 2006; 99(6): 636 - 645. [Abstract] [Full Text] [PDF]
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A. Beardsley, D. M Robertson, and L. O'Donnell A complex containing {alpha}6{beta}1-integrin and phosphorylated focal adhesion kinase between Sertoli cells and elongated spermatids during spermatid release from the seminiferous epithelium. J. Endocrinol., September 1, 2006; 190(3): 759 - 770. [Abstract] [Full Text] [PDF]
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 T. C. Sroka, M. E. Pennington, and A. E. Cress Synthetic D-amino acid peptide inhibits tumor cell motility on laminin-5 Carcinogenesis, September 1, 2006; 27(9): 1748 - 1757. [Abstract] [Full Text] [PDF]
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N. Desban, J.-C. Lissitzky, P. Rousselle, and J.-L. Duband {alpha}1{beta}1-integrin engagement to distinct laminin-1 domains orchestrates spreading, migration and survival of neural crest cells through independent signaling pathways J. Cell Sci., August 1, 2006; 119(15): 3206 - 3218. [Abstract] [Full Text] [PDF]
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F. Le Boeuf, F. Houle, M. Sussman, and J. Huot Phosphorylation of Focal Adhesion Kinase (FAK) on Ser732 Is Induced by Rho-dependent Kinase and Is Essential for Proline-rich Tyrosine Kinase-2-mediated Phosphorylation of FAK on Tyr407 in Response to Vascular Endothelial Growth Factor Mol. Biol. Cell, August 1, 2006; 17(8): 3508 - 3520. [Abstract] [Full Text] [PDF]
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Y. Sakamoto, H. Ogita, T. Hirota, T. Kawakatsu, T. Fukuyama, M. Yasumi, N. Kanzaki, M. Ozaki, and Y. Takai Interaction of Integrin {alpha}vbeta3 with Nectin: IMPLICATION IN CROSS-TALK BETWEEN CELL-MATRIX AND CELL-CELL JUNCTIONS J. Biol. Chem., July 14, 2006; 281(28): 19631 - 19644. [Abstract] [Full Text] [PDF]
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S.-Y. Chen and H.-C. Chen Direct Interaction of Focal Adhesion Kinase (FAK) with Met Is Required for FAK To Promote Hepatocyte Growth Factor-Induced Cell Invasion Mol. Cell. Biol., July 1, 2006; 26(13): 5155 - 5167. [Abstract] [Full Text] [PDF]
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N. N. Mon, H. Hasegawa, A. A. Thant, P. Huang, Y. Tanimura, T. Senga, and M. Hamaguchi A Role for Focal Adhesion Kinase Signaling in Tumor Necrosis Factor-{alpha}-Dependent Matrix Metalloproteinase-9 Production in a Cholangiocarcinoma Cell Line, CCKS1. Cancer Res., July 1, 2006; 66(13): 6778 - 6784. [Abstract] [Full Text] [PDF]
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K. Shiraishi and M. Ascoli Activation of the Lutropin/Choriogonadotropin Receptor in MA-10 Cells Stimulates Tyrosine Kinase Cascades that Activate Ras and the Extracellular Signal Regulated Kinases (ERK1/2) Endocrinology, July 1, 2006; 147(7): 3419 - 3427. [Abstract] [Full Text] [PDF]
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J. S. Swaney, H. H. Patel, U. Yokoyama, B. P. Head, D. M. Roth, and P. A. Insel Focal Adhesions in (Myo)fibroblasts Scaffold Adenylyl Cyclase with Phosphorylated Caveolin J. Biol. Chem., June 23, 2006; 281(25): 17173 - 17179. [Abstract] [Full Text] [PDF]
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J. H. Kim, H.-w. Kim, H. Jeon, P.-G. Suh, and S. H. Ryu Phospholipase D1 Regulates Cell Migration in a Lipase Activity-independent Manner J. Biol. Chem., June 9, 2006; 281(23): 15747 - 15756. [Abstract] [Full Text] [PDF]
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 K. He, J. Huang, C. F. Lagenaur, and E. Aizenman Methylisothiazolinone, A Neurotoxic Biocide, Disrupts the Association of Src Family Tyrosine Kinases with Focal Adhesion Kinase in Developing Cortical Neurons J. Pharmacol. Exp. Ther., June 1, 2006; 317(3): 1320 - 1329. [Abstract] [Full Text] [PDF]
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P. M.F. Siesser and S. K. Hanks The Signaling and Biological Implications of FAK Overexpression in Cancer. Clin. Cancer Res., June 1, 2006; 12(11): 3233 - 3237. [Full Text] [PDF]
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M. J. Bouchard, L. Wang, and R. J. Schneider Activation of Focal Adhesion Kinase by Hepatitis B Virus HBx Protein: Multiple Functions in Viral Replication J. Virol., May 1, 2006; 80(9): 4406 - 4414. [Abstract] [Full Text] [PDF]
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R. Eisen, S. Walid, D. R. Ratcliffe, and G. K. Ojakian Regulation of epithelial tubule formation by Rho family GTPases Am J Physiol Cell Physiol, May 1, 2006; 290(5): C1297 - C1309. [Abstract] [Full Text] [PDF]
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B. Gabriel, A. zur Hausen, E. Stickeler, C. Dietz, G. Gitsch, D.-C. Fischer, J. Bouda, C. Tempfer, and A. Hasenburg Weak Expression of Focal Adhesion Kinase (pp125FAK) in Patients with Cervical Cancer Is Associated with Poor Disease Outcome Clin. Cancer Res., April 15, 2006; 12(8): 2476 - 2483. [Abstract] [Full Text] [PDF]
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