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First published online April 16, 2004
doi: 10.1242/10.1242/jcs.01176

Journal of Cell Science 117, 1885-1897 (2004)
Published by The Company of Biologists 2004
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Commentary

Sticky worms: adhesion complexes in C. elegans

Elisabeth A. Cox* and Jeff Hardin

Department of Zoology, University of Wisconsin, 1117 W. Johnson Street, Madison, WI 53706, USA

* Author for correspondence (e-mail: eacox{at}wisc.edu)

Caenorhabditis elegans is a powerful model system for investigating the establishment, regulation and function of adhesive structures in vivo. C. elegans has several adhesion complexes related to those in vertebrates. These include: (1) epithelial apical junctions, which have features of both adherens and tight junctions; (2) dense bodies, which are muscle-attachment structures similar to focal adhesions; (3) fibrous organelles, which resemble hemidesmosomes and mediate mechanical coupling between tissues; and (4) a putative dystrophin-glycoprotein complex that has potential roles in muscle function and embryogenesis. Recent work has increased our understanding of these structures and has given new insights into the functions of their vertebrate counterparts.

Key words: Cell adhesion, Adherens junctions, Integrins, Hemidesmosomes, Dystrophin-glycoprotein complex


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