|
|
|
|
|
||
|
|||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | |||||
First published online May 4, 2004
doi: 10.1242/10.1242/jcs.01227
Commentary |
Massachusetts General Hospital Cancer Center, Bldg 149, 13th Street, Charlestown, MA 02129, USA
* Author for correspondence (e-mail: dyson{at}helix.mgh.harvard.edu)
Alterations in transcription of genes regulated by members of the E2F family of transcription factors can be viewed as a measure of the ebb and flow in a constantly evolving battle between repressor and activator complexes. Various chromatin regulatory complexes have been linked to Rb/E2F proteins, and changes in histone modifications correlate with states of E2F-dependent transcription. E2F has traditionally been viewed in the context of cell-cycle control. However, several recent studies have revealed a new aspect of E2F function in which pRB/E2F-family proteins confer stable repression of transcription. Such repression is evident in both actively proliferating cells and in cells that have withdrawn from the cell cycle.
Key words: Rb/E2F, Cell cycle, Transcription repression, Histone acetylation, Histone methylation
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  K. R. Stengel, C. Thangavel, D. A. Solomon, S. P. Angus, Y. Zheng, and E. S. Knudsen Retinoblastoma/p107/p130 Pocket Proteins: PROTEIN DYNAMICS AND INTERACTIONS WITH TARGET GENE PROMOTERS J. Biol. Chem., July 17, 2009; 284(29): 19265 - 19271. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Lee, J. A. Kim, V. Barbier, A. Fotedar, and R. Fotedar DNA Damage Triggers p21WAF1-dependent Emi1 Down-Regulation That Maintains G2 Arrest Mol. Biol. Cell, April 1, 2009; 20(7): 1891 - 1902. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. A. Sabelli, G. Hoerster, L. E. Lizarraga, S. W. Brown, W. J. Gordon-Kamm, and B. A. Larkins Positive regulation of minichromosome maintenance gene expression, DNA replication, and cell transformation by a plant retinoblastoma gene PNAS, March 10, 2009; 106(10): 4042 - 4047. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Suzuki, Y. Zhao, S. Ito, S. Sawatsubashi, T. Murata, T. Furutani, Y. Shirode, K. Yamagata, M. Tanabe, S. Kimura, et al. Aberrant E2F activation by polyglutamine expansion of androgen receptor in SBMA neurotoxicity PNAS, March 10, 2009; 106(10): 3818 - 3822. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Kornet and B. Scheres Stem Cell Factors in Plants: Chromatin Connections Cold Spring Harb Symp Quant Biol, January 15, 2009; (2009) sqb.2008.73.043v1. [Abstract] [PDF]
|
|
|
|
 |
|
 D Araujo-Vilar, G Lattanzi, B Gonzalez-Mendez, A T Costa-Freitas, D Prieto, M Columbaro, E Mattioli, B Victoria, N Martinez-Sanchez, A Ramazanova, et al. Site-dependent differences in both prelamin A and adipogenic genes in subcutaneous adipose tissue of patients with type 2 familial partial lipodystrophy J. Med. Genet., January 1, 2009; 46(1): 40 - 48. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. A. M. de Bruin, T. I. Kalashnikova, and C. Wittenberg Stb1 Collaborates with Other Regulators To Modulate the G1-Specific Transcriptional Circuit Mol. Cell. Biol., November 15, 2008; 28(22): 6919 - 6928. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Dutta, P. K. Patel, A. Rosebrock, A. Oliva, J. Leatherwood, and N. Rhind The DNA Replication Checkpoint Directly Regulates MBF-Dependent G1/S Transcription Mol. Cell. Biol., October 1, 2008; 28(19): 5977 - 5985. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Marlowe, Y. Fan, X. Chang, L. Peng, E. S. Knudsen, Y. Xia, and A. Puga The Aryl Hydrocarbon Receptor Binds to E2F1 and Inhibits E2F1-induced Apoptosis Mol. Biol. Cell, August 1, 2008; 19(8): 3263 - 3271. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. J. Genovese, N. S. Banerjee, T. R. Broker, and L. T. Chow Casein Kinase II Motif-Dependent Phosphorylation of Human Papillomavirus E7 Protein Promotes p130 Degradation and S-Phase Induction in Differentiated Human Keratinocytes J. Virol., May 15, 2008; 82(10): 4862 - 4873. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ashe, R. A. M. de Bruin, T. Kalashnikova, W. H. McDonald, J. R. Yates III, and C. Wittenberg The SBF- and MBF-associated Protein Msa1 Is Required for Proper Timing of G1-specific Transcription in Saccharomyces cerevisiae J. Biol. Chem., March 7, 2008; 283(10): 6040 - 6049. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Vandromme, C. Chailleux, F. Escaffit, and D. Trouche Binding of the Retinoblastoma Protein Is Not the Determinant for Stable Repression of Some E2F-Regulated Promoters in Muscle Cells Mol. Cancer Res., March 1, 2008; 6(3): 418 - 425. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Boehrer, L. Ades, T. Braun, L. Galluzzi, J. Grosjean, C. Fabre, G. Le Roux, C. Gardin, A. Martin, S. de Botton, et al. Erlotinib exhibits antineoplastic off-target effects in AML and MDS: a preclinical study Blood, February 15, 2008; 111(4): 2170 - 2180. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. A. Darnell, W. A. Schroder, T. M. Antalis, E. Lambley, L. Major, J. Gardner, G. Birrell, A. Cid-Arregui, and A. Suhrbier Human Papillomavirus E7 Requires the Protease Calpain to Degrade the Retinoblastoma Protein J. Biol. Chem., December 28, 2007; 282(52): 37492 - 37500. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Medina, M. van der Deen, A. Miele-Chamberland, R.-L. Xie, A. J. van Wijnen, J. L. Stein, and G. S. Stein The HiNF-P/p220NPAT Cell Cycle Signaling Pathway Controls Nonhistone Target Genes Cancer Res., November 1, 2007; 67(21): 10334 - 10342. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. B. Furnari, T. Fenton, R. M. Bachoo, A. Mukasa, J. M. Stommel, A. Stegh, W. C. Hahn, K. L. Ligon, D. N. Louis, C. Brennan, et al. Malignant astrocytic glioma: genetics, biology, and paths to treatment Genes & Dev., November 1, 2007; 21(21): 2683 - 2710. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. R. Calvi, B. A. Byrnes, and A. J. Kolpakas Conservation of Epigenetic Regulation, ORC Binding and Developmental Timing of DNA Replication Origins in the Genus Drosophila Genetics, November 1, 2007; 177(3): 1291 - 1301. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Garneau, L. Alvarez, M.-C. Paquin, C. Lussier, C. Rancourt, E. Tremblay, J.-F. Beaulieu, and N. Rivard Nuclear expression of E2F4 induces cell death via multiple pathways in normal human intestinal epithelial crypt cells but not in colon cancer cells Am J Physiol Gastrointest Liver Physiol, October 1, 2007; 293(4): G758 - G772. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Wang, B. Larris, T. H. Peiris, L. Zhang, J. Le Lay, Y. Gao, and L. E. Greenbaum C/EBPbeta Activates E2F-regulated Genes in Vivo via Recruitment of the Coactivator CREB-binding Protein/P300 J. Biol. Chem., August 24, 2007; 282(34): 24679 - 24688. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. W. Gunawardena, S. R. Fox, H. Siddiqui, and E. S. Knudsen SWI/SNF Activity Is Required for the Repression of Deoxyribonucleotide Triphosphate Metabolic Enzymes via the Recruitment of mSin3B J. Biol. Chem., July 13, 2007; 282(28): 20116 - 20123. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Sharma, C. E.S. Comstock, E. S. Knudsen, K. H. Cao, J. K. Hess-Wilson, L. M. Morey, J. Barrera, and K. E. Knudsen Retinoblastoma Tumor Suppressor Status Is a Critical Determinant of Therapeutic Response in Prostate Cancer Cells Cancer Res., July 1, 2007; 67(13): 6192 - 6203. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Hayakawa, Y. Ohtani, N. Hayakawa, K. Shinmyozu, M. Saito, F. Ishikawa, and J.-i. Nakayama RBP2 is an MRG15 complex component and down-regulates intragenic histone H3 lysine 4 methylation Genes Cells, June 1, 2007; 12(6): 811 - 826. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Lu, M.-L. Ruhf, N. Perrimon, and P. Leder A genome-wide RNA interference screen identifies putative chromatin regulators essential for E2F repression PNAS, May 29, 2007; 104(22): 9381 - 9386. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. W. Reddien, E. C. Andersen, M. C. Huang, and H. R. Horvitz DPL-1 DP, LIN-35 Rb and EFL-1 E2F Act With the MCD-1 Zinc-Finger Protein to Promote Programmed Cell Death in Caenorhabditis elegans Genetics, April 1, 2007; 175(4): 1719 - 1733. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Ullah, M. S. Buckley, D. N. Arnosti, and R. W. Henry Retinoblastoma Protein Regulation by the COP9 Signalosome Mol. Biol. Cell, April 1, 2007; 18(4): 1179 - 1186. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Johung, E. C. Goodwin, and D. DiMaio Human Papillomavirus E7 Repression in Cervical Carcinoma Cells Initiates a Transcriptional Cascade Driven by the Retinoblastoma Family, Resulting in Senescence J. Virol., March 1, 2007; 81(5): 2102 - 2116. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Shibutani, L. M. Swanhart, and R. J. Duronio Rbf1-independent termination of E2f1-target gene expression during early Drosophila embryogenesis Development, February 1, 2007; 134(3): 467 - 478. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Maeda, V. Dave, and J. A. Whitsett Transcriptional Control of Lung Morphogenesis Physiol Rev, January 1, 2007; 87(1): 219 - 244. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Reimer, S. Sadr, A. Wiedemair, S. Stadlmann, N. Concin, G. Hofstetter, E. Muller-Holzner, C. Marth, and A. G. Zeimet Clinical Relevance of E2F Family Members in Ovarian Cancer--An Evaluation in a Training Set of 77 Patients Clin. Cancer Res., January 1, 2007; 13(1): 144 - 151. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L.-J. Zhao, T. Subramanian, and G. Chinnadurai Changes in C-terminal Binding Protein 2 (CtBP2) Corepressor Complex Induced by E1A and Modulation of E1A Transcriptional Activity by CtBP2 J. Biol. Chem., December 1, 2006; 281(48): 36613 - 36623. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. A. Braden, J. M. Lenihan, Z. Lan, K. S. Luce, W. Zagorski, E. Bosco, M. F. Reed, J. G. Cook, and E. S. Knudsen Distinct Action of the Retinoblastoma Pathway on the DNA Replication Machinery Defines Specific Roles for Cyclin-Dependent Kinase Complexes in Prereplication Complex Assembly and S-Phase Progression Mol. Cell. Biol., October 15, 2006; 26(20): 7667 - 7681. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Zhang, M. Liao, and M. L. Dufau Phosphatidylinositol 3-Kinase/Protein Kinase C{zeta}-Induced Phosphorylation of Sp1 and p107 Repressor Release Have a Critical Role in Histone Deacetylase Inhibitor-Mediated Depression of Transcription of the Luteinizing Hormone Receptor Gene Mol. Cell. Biol., September 15, 2006; 26(18): 6748 - 6761. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Aiello, G. Pandini, F. Frasca, E. Conte, A. Murabito, A. Sacco, M. Genua, R. Vigneri, and A. Belfiore Peroxisomal Proliferator-Activated Receptor-{gamma} Agonists Induce Partial Reversion of Epithelial-Mesenchymal Transition in Anaplastic Thyroid Cancer Cells Endocrinology, September 1, 2006; 147(9): 4463 - 4475. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. B. Nijman, E. M. Hijmans, S. E. Messaoudi, M. M. W. van Dongen, C. Sardet, and R. Bernards A Functional Genetic Screen Identifies TFE3 as a Gene That Confers Resistance to the Anti-proliferative Effects of the Retinoblastoma Protein and Transforming Growth Factor-beta J. Biol. Chem., August 4, 2006; 281(31): 21582 - 21587. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. T. Nitta, S. A. Jameson, B. A. Kudlow, L. A. Conlan, and B. K. Kennedy Stabilization of the Retinoblastoma Protein by A-Type Nuclear Lamins Is Required for INK4A-Mediated Cell Cycle Arrest Mol. Cell. Biol., July 15, 2006; 26(14): 5360 - 5372. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. F. Reed, W. A. Zagorski, J. A. Howington, J. T. Zilfou, and E. S. Knudsen Inhibition of retinoblastoma tumor suppressor activity by RNA interference in lung cancer lines. Ann. Thorac. Surg., July 1, 2006; 82(1): 249 - 253. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Louie, A. S. Revenko, J. X. Zou, J. Yao, and H.-W. Chen Direct Control of Cell Cycle Gene Expression by Proto-Oncogene Product ACTR, and Its Autoregulation Underlies Its Transforming Activity Mol. Cell. Biol., May 15, 2006; 26(10): 3810 - 3823. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. W. Harbour Eye Cancer: Unique Insights into Oncogenesis The Cogan Lecture Invest. Ophthalmol. Vis. Sci., May 1, 2006; 47(5): 1737 - 1745. [Full Text] [PDF]
|
|
|
|
 |
|
 M. Bieda, X. Xu, M. A. Singer, R. Green, and P. J. Farnham Unbiased location analysis of E2F1-binding sites suggests a widespread role for E2F1 in the human genome Genome Res., May 1, 2006; 16(5): 595 - 605. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Liu and W.-H. Lee CtIP Activates Its Own and Cyclin D1 Promoters via the E2F/RB Pathway during G1/S Progression Mol. Cell. Biol., April 15, 2006; 26(8): 3124 - 3134. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Dorner, S. Vlcek, N. Foeger, A. Gajewski, C. Makolm, J. Gotzmann, C. J. Hutchison, and R. Foisner Lamina-associated polypeptide 2{alpha} regulates cell cycle progression and differentiation via the retinoblastoma-E2F pathway. J. Cell Biol., April 10, 2006; 173(1): 83 - 93. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. G. Jackson and O. M. Pereira-Smith Primary and Compensatory Roles for RB Family Members at Cell Cycle Gene Promoters That Are Deacetylated and Downregulated in Doxorubicin-Induced Senescence of Breast Cancer Cells Mol. Cell. Biol., April 1, 2006; 26(7): 2501 - 2510. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Chesney, A. R. Kidd III, and J. Kimble gon-14 Functions With Class B and Class C Synthetic Multivulva Genes to Control Larval Growth in Caenorhabditis elegans Genetics, February 1, 2006; 172(2): 915 - 928. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Grishok and P. A. Sharp Negative regulation of nuclear divisions in Caenorhabditis elegans by retinoblastoma and RNA interference-related genes PNAS, November 29, 2005; 102(48): 17360 - 17365. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Guo, G. Sheng, and B. W. Warner Epidermal Growth Factor-induced Rapid Retinoblastoma Phosphorylation at Ser780 and Ser795 Is Mediated by ERK1/2 in Small Intestine Epithelial Cells J. Biol. Chem., October 28, 2005; 280(43): 35992 - 35998. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A. Sabelli, R. A. Dante, J. T. Leiva-Neto, R. Jung, W. J. Gordon-Kamm, and B. A. Larkins Inaugural Article: RBR3, a member of the retinoblastoma-related family from maize, is regulated by the RBR1/E2F pathway PNAS, September 13, 2005; 102(37): 13005 - 13012. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Jung, T.-g. Kim, G. E. Lyons, H.-R. C. Kim, and Y. Lee Jumonji Regulates Cardiomyocyte Proliferation via Interaction with Retinoblastoma Protein J. Biol. Chem., September 2, 2005; 280(35): 30916 - 30923. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Krajewska, H. Kim, C. Kim, H. Kang, K. Welsh, S.-i. Matsuzawa, M. Tsukamoto, R. G. Thomas, N. Assa-Munt, Z. Piao, et al. Analysis of Apoptosis Protein Expression in Early-Stage Colorectal Cancer Suggests Opportunities for New Prognostic Biomarkers Clin. Cancer Res., August 1, 2005; 11(15): 5451 - 5461. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Markovics, P. A. Carroll, M. T. S. Robles, H. Pope, C. M. Coopersmith, and J. M. Pipas Intestinal Dysplasia Induced by Simian Virus 40 T Antigen Is Independent of p53 J. Virol., June 15, 2005; 79(12): 7492 - 7502. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Nemethova, M. Smutny, and E. Wintersberger Transactivation of E2F-Regulated Genes by Polyomavirus Large T Antigen: Evidence for a Two-Step Mechanism Mol. Cell. Biol., December 15, 2004; 24(24): 10986 - 10994. [Abstract] [Full Text] [PDF]
|
|
