spacer gif spacer gif spacer gif spacer gif Propose a workshop for 2011 spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

First published online May 28, 2004
doi: 10.1242/10.1242/jcs.01131

Journal of Cell Science 117, 2805-2812 (2004)
Published by The Company of Biologists 2004
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kabeya, Y.
Right arrow Articles by Yoshimori, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kabeya, Y.
Right arrow Articles by Yoshimori, T.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Research Article

LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation

Yukiko Kabeya1, Noboru Mizushima1,2,*, Akitsugu Yamamoto3, Satsuki Oshitani-Okamoto1, Yoshinori Ohsumi1 and Tamotsu Yoshimori1,4,5,6,{ddagger}

1 Department of Cell Biology, National Institute for Basic Biology, Myodaiji 38, Okazaki 444-8585, Japan
2 PRESTO, Japan Science and Technology Agency, Honcho 4-1-8, Kawaguchi 332-0012, Japan
3 Department of Bio-Science, Nagahama Institute of Bio-Science and Technology, Tamura 1266, Nagahama 526-0829, Japan
4 Department of Cell Genetics, National Institute of Genetics, Yata 1111, Mishima 411-8540, Japan
5 Department of Genetics, The Graduate University for Advanced Studies, Yata 1111, Mishima 411-8540, Japan
6 CREST, Japan Science and Technology Agency, Honcho 4-1-8, Kawaguchi 332-0012, Japan

{ddagger} Author for correspondence (e-mail: tamyoshi{at}lab.nig.ac.jp)

Accepted 30 January 2004

Rat LC3, a homologue of yeast Atg8 (Aut7/Apg8), localizes to autophagosomal membranes after post-translational modifications. The C-terminal fragment of LC3 is cleaved immediately following synthesis to yield a cytosolic form called LC3-I. A subpopulation of LC3-I is further converted to an autophagosome-associating form, LC3-II.

Because yeast Atg8 is conjugated with phosphatidylethanolamine (PE) by a ubiquitin-like system, it has been hypothesized that LC3 is modified in a similar manner. Here, we show that [14C]-ethanolamine was preferentially incorporated into LC3-II, suggesting that LC3-II is a PE-conjugated form. LC3-II can be a substrate of mammalian Atg4B, a homologue of yeast Atg8-PE deconjugase, supporting the idea that LC3-II is LC3-PE. Moreover, two other mammalian homologues of yeast Atg8, {gamma}-aminobutyric-acid-type-A-receptor-associated protein (GABARAP) and Golgi-associated ATPase enhancer of 16 kDa (GATE16) also generate form II, which are recovered in membrane fractions. Generation of the form II correlates with autophagosome association of GABARAP and GATE16. These results suggest that all mammalian Atg8 homologues receive a common modification to associate with autophagosomal membrane as the form II.

Key words: Autophagy, ATG, Autophagosome, UBL, Deconjugation, Phosphatidylethanolamine


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Int ImmunolHome page
T. Noda and T. Yoshimori
Molecular basis of canonical and bactericidal autophagy
Int. Immunol., November 1, 2009; 21(11): 1199 - 1204.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L. Baisamy, S. Cavin, N. Jurisch, and D. Diviani
The Ubiquitin-like Protein LC3 Regulates the Rho-GEF Activity of AKAP-Lbc
J. Biol. Chem., October 9, 2009; 284(41): 28232 - 28242.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
L. Zhou, J. Zhang, Q. Fang, M. Liu, X. Liu, W. Jia, L. Q. Dong, and F. Liu
Autophagy-Mediated Insulin Receptor Down-Regulation Contributes to Endoplasmic Reticulum Stress-Induced Insulin Resistance
Mol. Pharmacol., September 1, 2009; 76(3): 596 - 603.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Dreux, P. Gastaminza, S. F. Wieland, and F. V. Chisari
The autophagy machinery is required to initiate hepatitis C virus replication
PNAS, August 18, 2009; 106(33): 14046 - 14051.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. Wang, M. W. Whiteman, H. Lian, G. Wang, A. Singh, D. Huang, and T. Denmark
A Non-canonical MEK/ERK Signaling Pathway Regulates Autophagy via Regulating Beclin 1
J. Biol. Chem., August 7, 2009; 284(32): 21412 - 21424.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Bains, M. L. Florez-McClure, and K. A. Heidenreich
Insulin-like Growth Factor-I Prevents the Accumulation of Autophagic Vesicles and Cell Death in Purkinje Neurons by Increasing the Rate of Autophagosome-to-lysosome Fusion and Degradation
J. Biol. Chem., July 24, 2009; 284(30): 20398 - 20407.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
J. Zhang, M. S. Randall, M. R. Loyd, F. C. Dorsey, M. Kundu, J. L. Cleveland, and P. A. Ney
Mitochondrial clearance is regulated by Atg7-dependent and -independent mechanisms during reticulocyte maturation
Blood, July 2, 2009; 114(1): 157 - 164.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
C. Huttenhower, E. M. Haley, M. A. Hibbs, V. Dumeaux, D. R. Barrett, H. A. Coller, and O. G. Troyanskaya
Exploring the human genome with functional maps
Genome Res., June 1, 2009; 19(6): 1093 - 1106.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
L. Ying, A. Lau, C. M. Alvira, R. West, G. M. Cann, B. Zhou, C. Kinnear, E. Jan, P. Sarnow, M. Van de Rijn, et al.
LC3-mediated fibronectin mRNA translation induces fibrosarcoma growth by increasing connective tissue growth factor
J. Cell Sci., May 1, 2009; 122(9): 1441 - 1451.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
C. H. Jung, C. B. Jun, S.-H. Ro, Y.-M. Kim, N. M. Otto, J. Cao, M. Kundu, and D.-H. Kim
ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery
Mol. Biol. Cell, April 1, 2009; 20(7): 1992 - 2003.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
J. Nowak, C. Archange, J. Tardivel-Lacombe, P. Pontarotti, M.-J. Pebusque, M. I. Vaccaro, G. Velasco, J.-C. Dagorn, and J. L. Iovanna
The TP53INP2 Protein Is Required for Autophagy in Mammalian Cells
Mol. Biol. Cell, February 1, 2009; 20(3): 870 - 881.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Chen, C. Chen, E. Kotsikorou, D. L. Lynch, P. H. Reggio, and L.-Y. Liu-Chen
GEC1-{kappa} Opioid Receptor Binding Involves Hydrophobic Interactions: GEC1 HAS CHAPERONE-LIKE EFFECT
J. Biol. Chem., January 16, 2009; 284(3): 1673 - 1685.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S.-E Choi, S.-M. Lee, Y.-J. Lee, L.-J. Li, S.-J. Lee, J.-H. Lee, Y. Kim, H.-S. Jun, K.-W. Lee, and Y. Kang
Protective Role of Autophagy in Palmitate-Induced INS-1 {beta}-Cell Death
Endocrinology, January 1, 2009; 150(1): 126 - 134.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J.-L. Chen, H. H. Lin, K.-J. Kim, A. Lin, H. J. Forman, and D. K. Ann
Novel Roles for Protein Kinase C{delta}-dependent Signaling Pathways in Acute Hypoxic Stress-induced Autophagy
J. Biol. Chem., December 5, 2008; 283(49): 34432 - 34444.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
W. Shui, L. Sheu, J. Liu, B. Smart, C. J. Petzold, T.-y. Hsieh, A. Pitcher, J. D. Keasling, and C. R. Bertozzi
Membrane proteomics of phagosomes suggests a connection to autophagy
PNAS, November 4, 2008; 105(44): 16952 - 16957.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
Y.-s. Sou, S. Waguri, J.-i. Iwata, T. Ueno, T. Fujimura, T. Hara, N. Sawada, A. Yamada, N. Mizushima, Y. Uchiyama, et al.
The Atg8 Conjugation System Is Indispensable for Proper Development of Autophagic Isolation Membranes in Mice
Mol. Biol. Cell, November 1, 2008; 19(11): 4762 - 4775.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
N. Fujita, M. Hayashi-Nishino, H. Fukumoto, H. Omori, A. Yamamoto, T. Noda, and T. Yoshimori
An Atg4B Mutant Hampers the Lipidation of LC3 Paralogues and Causes Defects in Autophagosome Closure
Mol. Biol. Cell, November 1, 2008; 19(11): 4651 - 4659.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
C. Chu and A. J. Shatkin
Apoptosis and Autophagy Induction in Mammalian Cells by Small Interfering RNA Knockdown of mRNA Capping Enzymes
Mol. Cell. Biol., October 1, 2008; 28(19): 5829 - 5836.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
D. L. Burdette, M. L. Yarbrough, A. Orvedahl, C. J. Gilpin, and K. Orth
Vibrio parahaemolyticus orchestrates a multifaceted host cell infection by induction of autophagy, cell rounding, and then cell lysis
PNAS, August 26, 2008; 105(34): 12497 - 12502.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Ichimura, T. Kumanomidou, Y.-s. Sou, T. Mizushima, J. Ezaki, T. Ueno, E. Kominami, T. Yamane, K. Tanaka, and M. Komatsu
Structural Basis for Sorting Mechanism of p62 in Selective Autophagy
J. Biol. Chem., August 15, 2008; 283(33): 22847 - 22857.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
E. Shvets, E. Fass, R. Scherz-Shouval, and Z. Elazar
The N-terminus and Phe52 residue of LC3 recruit p62/SQSTM1 into autophagosomes
J. Cell Sci., August 15, 2008; 121(16): 2685 - 2695.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
Z. Xie, U. Nair, and D. J. Klionsky
Atg8 Controls Phagophore Expansion during Autophagosome Formation
Mol. Biol. Cell, August 1, 2008; 19(8): 3290 - 3298.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Signorell, J. Jelk, M. Rauch, and P. Butikofer
Phosphatidylethanolamine Is the Precursor of the Ethanolamine Phosphoglycerol Moiety Bound to Eukaryotic Elongation Factor 1A
J. Biol. Chem., July 18, 2008; 283(29): 20320 - 20329.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
T. Nakamura, T. Hayashi, Y. Nasu-Nishimura, F. Sakaue, Y. Morishita, T. Okabe, S. Ohwada, K. Matsuura, and T. Akiyama
PX-RICS mediates ER-to-Golgi transport of the N-cadherin/{beta}-catenin complex
Genes & Dev., May 1, 2008; 22(9): 1244 - 1256.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
F. Lazaro-Dieguez, C. Aguado, E. Mato, Y. Sanchez-Ruiz, I. Esteban, J. Alberch, E. Knecht, and G. Egea
Dynamics of an F-actin aggresome generated by the actin-stabilizing toxin jasplakinolide
J. Cell Sci., May 1, 2008; 121(9): 1415 - 1425.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
N. Fujita, T. Itoh, H. Omori, M. Fukuda, T. Noda, and T. Yoshimori
The Atg16L Complex Specifies the Site of LC3 Lipidation for Membrane Biogenesis in Autophagy
Mol. Biol. Cell, May 1, 2008; 19(5): 2092 - 2100.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
V. E. Alvarez, G. Kosec, C. Sant'Anna, V. Turk, J. J. Cazzulo, and B. Turk
Autophagy Is Involved in Nutritional Stress Response and Differentiation in Trypanosoma cruzi
J. Biol. Chem., February 8, 2008; 283(6): 3454 - 3464.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
R. L. Schweers, J. Zhang, M. S. Randall, M. R. Loyd, W. Li, F. C. Dorsey, M. Kundu, J. T. Opferman, J. L. Cleveland, J. L. Miller, et al.
NIX is required for programmed mitochondrial clearance during reticulocyte maturation
PNAS, December 4, 2007; 104(49): 19500 - 19505.
[Abstract] [Full Text] [PDF]

Home page
 Microbiol. Mol. Biol. Rev.Home page
J. H. Brumell and M. A. Scidmore
Manipulation of Rab GTPase Function by Intracellular Bacterial Pathogens
Microbiol. Mol. Biol. Rev., December 1, 2007; 71(4): 636 - 652.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
M. P. Taylor and K. Kirkegaard
Modification of Cellular Autophagy Protein LC3 by Poliovirus
J. Virol., November 15, 2007; 81(22): 12543 - 12553.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
M. Filimonenko, S. Stuffers, C. Raiborg, A. Yamamoto, L. Malerod, E. M.C. Fisher, A. Isaacs, A. Brech, H. Stenmark, and A. Simonsen
Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease
J. Cell Biol., November 5, 2007; 179(3): 485 - 500.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
N. Jounai, F. Takeshita, K. Kobiyama, A. Sawano, A. Miyawaki, K.-Q. Xin, K. J. Ishii, T. Kawai, S. Akira, K. Suzuki, et al.
The Atg5 Atg12 conjugate associates with innate antiviral immune responses
PNAS, August 28, 2007; 104(35): 14050 - 14055.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Pankiv, T. H. Clausen, T. Lamark, A. Brech, J.-A. Bruun, H. Outzen, A. Overvatn, G. Bjorkoy, and T. Johansen
p62/SQSTM1 Binds Directly to Atg8/LC3 to Facilitate Degradation of Ubiquitinated Protein Aggregates by Autophagy
J. Biol. Chem., August 17, 2007; 282(33): 24131 - 24145.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. Ieguchi, S. Ueda, T. Kataoka, and T. Satoh
Role of the Guanine Nucleotide Exchange Factor Ost in Negative Regulation of Receptor Endocytosis by the Small GTPase Rac1
J. Biol. Chem., August 10, 2007; 282(32): 23296 - 23305.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
K.-J. Park, S.-H. Lee, T.-I. Kim, H.-W. Lee, C.-H. Lee, E.-H. Kim, J.-Y. Jang, K. S. Choi, M.-H. Kwon, and Y.-S. Kim
A Human scFv Antibody against TRAIL Receptor 2 Induces Autophagic Cell Death in Both TRAIL-Sensitive and TRAIL-Resistant Cancer Cells
Cancer Res., August 1, 2007; 67(15): 7327 - 7334.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
G. Marino, N. Salvador-Montoliu, A. Fueyo, E. Knecht, N. Mizushima, and C. Lopez-Otin
Tissue-specific Autophagy Alterations and Increased Tumorigenesis in Mice Deficient in Atg4C/Autophagin-3
J. Biol. Chem., June 22, 2007; 282(25): 18573 - 18583.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
Z.-W. Chen, C.-S. S. Chang, T. A. Leil, and R. W. Olsen
C-Terminal Modification Is Required for GABARAP-Mediated GABAA Receptor Trafficking
J. Neurosci., June 20, 2007; 27(25): 6655 - 6663.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
D. Kessel, J. J. Reiners Jr., S. T. Hazeldine, L. Polin, and J. P. Horwitz
The role of autophagy in the death of L1210 leukemia cells initiated by the new antitumor agents, XK469 and SH80
Mol. Cancer Ther., January 1, 2007; 6(1): 370 - 379.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
M. Ogata, S.-i. Hino, A. Saito, K. Morikawa, S. Kondo, S. Kanemoto, T. Murakami, M. Taniguchi, I. Tanii, K. Yoshinaga, et al.
Autophagy Is Activated for Cell Survival after Endoplasmic Reticulum Stress
Mol. Cell. Biol., December 15, 2006; 26(24): 9220 - 9231.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
E. Fass, E. Shvets, I. Degani, K. Hirschberg, and Z. Elazar
Microtubules Support Production of Starvation-induced Autophagosomes but Not Their Targeting and Fusion with Lysosomes
J. Biol. Chem., November 24, 2006; 281(47): 36303 - 36316.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
F. Demarchi, C. Bertoli, T. Copetti, I. Tanida, C. Brancolini, E.-L. Eskelinen, and C. Schneider
Calpain is required for macroautophagy in mammalian cells
J. Cell Biol., November 20, 2006; 175(4): 595 - 605.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Djavaheri-Mergny, M. Amelotti, J. Mathieu, F. Besancon, C. Bauvy, S. Souquere, G. Pierron, and P. Codogno
NF-{kappa}B Activation Represses Tumor Necrosis Factor-{alpha}-induced Autophagy
J. Biol. Chem., October 13, 2006; 281(41): 30373 - 30382.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Hamacher-Brady, N. R. Brady, and R. A. Gottlieb
Enhancing Macroautophagy Protects against Ischemia/Reperfusion Injury in Cardiac Myocytes
J. Biol. Chem., October 6, 2006; 281(40): 29776 - 29787.
[Abstract] [Full Text] [PDF]

Home page
 Eukaryot CellHome page
T. Tekinay, M. Y. Wu, G. P. Otto, O. R. Anderson, and R. H. Kessin
Function of the Dictyostelium discoideum Atg1 Kinase during Autophagy and Development.
Eukaryot. Cell, October 1, 2006; 5(10): 1797 - 1806.
[Abstract] [Full Text] [PDF]

Home page
 J BiochemHome page
A. Amano, I. Nakagawa, and T. Yoshimori
Autophagy in Innate Immunity against Intracellular Bacteria
J. Biochem., August 1, 2006; 140(2): 161 - 166.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Shibata, T. Lu, T. Furuya, A. Degterev, N. Mizushima, T. Yoshimori, M. MacDonald, B. Yankner, and J. Yuan
Regulation of Intracellular Accumulation of Mutant Huntingtin by Beclin 1
J. Biol. Chem., May 19, 2006; 281(20): 14474 - 14485.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Kamimoto, S. Shoji, T. Hidvegi, N. Mizushima, K. Umebayashi, D. H. Perlmutter, and T. Yoshimori
Intracellular Inclusions Containing Mutant {alpha}1-Antitrypsin Z Are Propagated in the Absence of Autophagic Activity
J. Biol. Chem., February 17, 2006; 281(7): 4467 - 4476.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y.-s. Sou, I. Tanida, M. Komatsu, T. Ueno, and E. Kominami
Phosphatidylserine in Addition to Phosphatidylethanolamine Is an in Vitro Target of the Mammalian Atg8 Modifiers, LC3, GABARAP, and GATE-16
J. Biol. Chem., February 10, 2006; 281(6): 3017 - 3024.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. M. Rowland, J. E. Richmond, J. G. Olsen, D. H. Hall, and B. A. Bamber
Presynaptic Terminals Independently Regulate Synaptic Clustering and Autophagy of GABAA Receptors in Caenorhabditis elegans
J. Neurosci., February 8, 2006; 26(6): 1711 - 1720.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. Sugawara, N. N. Suzuki, Y. Fujioka, N. Mizushima, Y. Ohsumi, and F. Inagaki
Structural Basis for the Specificity and Catalysis of Human Atg4B Responsible for Mammalian Autophagy
J. Biol. Chem., December 2, 2005; 280(48): 40058 - 40065.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
G. Bjorkoy, T. Lamark, A. Brech, H. Outzen, M. Perander, A. Overvatn, H. Stenmark, and T. Johansen
p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death
J. Cell Biol., November 21, 2005; 171(4): 603 - 614.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
W. H. Yu, A. M. Cuervo, A. Kumar, C. M. Peterhoff, S. D. Schmidt, J.-H. Lee, P. S. Mohan, M. Mercken, M. R. Farmery, L. O. Tjernberg, et al.
Macroautophagy--a novel {beta}-amyloid peptide-generating pathway activated in Alzheimer's disease
J. Cell Biol., October 10, 2005; 171(1): 87 - 98.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Kouno, M. Mizuguchi, I. Tanida, T. Ueno, T. Kanematsu, Y. Mori, H. Shinoda, M. Hirata, E. Kominami, and K. Kawano
Solution Structure of Microtubule-associated Protein Light Chain 3 and Identification of Its Functional Subdomains
J. Biol. Chem., July 1, 2005; 280(26): 24610 - 24617.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
M. Komatsu, S. Waguri, T. Ueno, J. Iwata, S. Murata, I. Tanida, J. Ezaki, N. Mizushima, Y. Ohsumi, Y. Uchiyama, et al.
Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice
J. Cell Biol., May 9, 2005; 169(3): 425 - 434.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Yamada, A. R. Carson, I. Caniggia, K. Umebayashi, T. Yoshimori, K. Nakabayashi, and S. W. Scherer
Endothelial Nitric-oxide Synthase Antisense (NOS3AS) Gene Encodes an Autophagy-related Protein (APG9-like2) Highly Expressed in Trophoblast
J. Biol. Chem., May 6, 2005; 280(18): 18283 - 18290.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
D. J. Klionsky
The molecular machinery of autophagy: unanswered questions
J. Cell Sci., January 1, 2005; 118(1): 7 - 18.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
K. Yoshimoto, H. Hanaoka, S. Sato, T. Kato, S. Tabata, T. Noda, and Y. Ohsumi
Processing of ATG8s, Ubiquitin-Like Proteins, and Their Deconjugation by ATG4s Are Essential for Plant Autophagy
PLANT CELL, November 1, 2004; 16(11): 2967 - 2983.
[Abstract] [Full Text] [PDF]

Home page
 GENES CELLSHome page
K. Sugawara, N. N. Suzuki, Y. Fujioka, N. Mizushima, Y. Ohsumi, and F. Inagaki
The crystal structure of microtubule-associated protein light chain 3, a mammalian homologue of Saccharomyces cerevisiae Atg8
Genes Cells, July 1, 2004; 9(7): 611 - 618.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2004