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First published online 29 June 2004
doi: 10.1242/jcs.01222

Journal of Cell Science 117, 3539-3545 (2004)
Published by The Company of Biologists 2004
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Research Article

CD133, a novel marker for human prostatic epithelial stem cells

Gavin D. Richardson1, Craig N. Robson1, Shona H. Lang2, David E. Neal3, Norman J. Maitland2 and Anne T. Collins2,*

1 Prostate Research Group, Surgical Oncology, Medical School, Framlington Place, University of Newcastle upon Tyne, Newcastle upon Tyne, NE2 4HH, UK
2 YCR Cancer Research Unit (Area 13), Department of Biology, University of York, PO BOX 373, York, YO10 5DD, UK
3 Department of Oncology, Addenbrooke's Hospital, University of Cambridge, Hills Road, Cambridge, CB2 2QQ, UK

* Author for correspondence (e-mail: ac43{at}york.ac.uk)

Accepted 15 March 2004

Stem cells are clonogenic cells with self-renewal and differentiation properties, which may represent a major target for genetic damage leading to prostate cancer and benign prostatic hyperplasia. Stem cells remain poorly characterised because of the absence of specific molecular markers that permit us to distinguish them from their progeny, the transit amplifying cells, which have a more restricted proliferative potential. Human CD133 antigen, also known as AC133, was recently identified as a haematopoietic stem cell marker. Here we show that a small population (approximately 1%) of human prostate basal cells express the cell surface marker CD133 and are restricted to the {alpha}2ß1hi population, previously shown to be a marker of stem cells in prostate epithelia (Collins, A. T., Habib, F. K., Maitland, N. J. and Neal, D. E. (2001). J. Cell Sci. 114, 3865-3872). {alpha}2ß1hi/CD133+ cells exhibit two important attributes of epithelial stem cells: they possess a high in vitro proliferative potential and can reconstitute prostatic-like acini in immunocompromised male nude mice.

Key words: Stem cells, CD133, Integrins, Prostate


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