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First published online September 15, 2004
doi: 10.1242/10.1242/jcs.01481

Journal of Cell Science 117, 4619-4628 (2004)
Published by The Company of Biologists 2004
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Commentary

MAP kinases and cell migration

Cai Huang1,*, Ken Jacobson1,2,3 and Michael D. Schaller1,2,3,{ddagger}

1 Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, NC 27599-7090, USA
2 Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599-7090, USA
3 Comprehensive Center for Inflammatory Disorders, University of North Carolina, Chapel Hill, NC 27599-7090, USA

{ddagger} Author for correspondence (e-mail: crispy4{at}med.unc.edu)

Recent studies have demonstrated that mitogen-activated protein kinases (MAPKs), including Jun N-terminus kinase (JNK), p38 and Erk, play crucial roles in cell migration. JNK, for example, regulates cell migration by phosphorylating paxillin, DCX, Jun and microtubule-associated proteins. Studies of p38 show that this MAPK modulates migration by phosphorylating MAPK-activated protein kinase 2/3 (MAPKAP 2/3), which appears to be important for directionality of migration. Erk governs cell movement by phosphorylating myosin light chain kinase (MLCK), calpain or FAK. Thus, the different kinases in the MAPK family all seem able to regulate cell migration but by distinct mechanisms.

Key words: Cell migration, JNK, p38, Erk, Paxillin, Phosphorylation


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Microtubule-Destabilizing Agents Induce Focal Adhesion Structure Disorganization and Anoikis in Cancer Cells
J. Pharmacol. Exp. Ther., February 1, 2007; 320(2): 853 - 864.
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 JCBHome page
C. Tolg, S. R. Hamilton, K.-A. Nakrieko, F. Kooshesh, P. Walton, J. B. McCarthy, M. J. Bissell, and E. A. Turley
Rhamm-/- fibroblasts are defective in CD44-mediated ERK1,2 motogenic signaling, leading to defective skin wound repair
J. Cell Biol., December 18, 2006; 175(6): 1017 - 1028.
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 Cancer Res.Home page
C.-L. Tsai, H.-P. Li, Y.-J. Lu, C. Hsueh, Y. Liang, C.-L. Chen, S. W. Tsao, K.-P. Tse, J.-S. Yu, and Y.-S. Chang
Activation of DNA Methyltransferase 1 by EBV LMP1 Involves c-Jun NH2-Terminal Kinase Signaling
Cancer Res., December 15, 2006; 66(24): 11668 - 11676.
[Abstract] [Full Text] [PDF]

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 BloodHome page
K. Szczur, H. Xu, S. Atkinson, Y. Zheng, and M.-D. Filippi
Rho GTPase CDC42 regulates directionality and random movement via distinct MAPK pathways in neutrophils
Blood, December 15, 2006; 108(13): 4205 - 4213.
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 Cancer Res.Home page
L. Yen, Z. Cao, X. Wu, E. R.Q. Ingalla, C. Baron, L. J.T. Young, J. P. Gregg, R. D. Cardiff, A. D. Borowsky, C. Sweeney, et al.
Loss of Nrdp1 Enhances ErbB2/ErbB3-Dependent Breast Tumor Cell Growth
Cancer Res., December 1, 2006; 66(23): 11279 - 11286.
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 Cancer Res.Home page
F. Acconcia, B. Manavathi, J. Mascarenhas, A. H. Talukder, G. Mills, and R. Kumar
An Inherent Role of Integrin-Linked Kinase-Estrogen Receptor {alpha} Interaction in Cell Migration.
Cancer Res., November 15, 2006; 66(22): 11030 - 11038.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
N. Asai, T. Fukuda, Z. Wu, A. Enomoto, V. Pachnis, M. Takahashi, and F. Costantini
Targeted mutation of serine 697 in the Ret tyrosine kinase causes migration defect of enteric neural crest cells
Development, November 15, 2006; 133(22): 4507 - 4516.
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 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
J. Benitez-Rajal, M.-J. Lorite, A. D. Burt, C. P. Day, and M. G. Thompson
Phospholipase D and extracellular signal-regulated kinase in hepatic stellate cells: effects of platelet-derived growth factor and extracellular nucleotides.
Am J Physiol Gastrointest Liver Physiol, November 1, 2006; 291(5): G977 - G986.
[Abstract] [Full Text] [PDF]

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 Molecular Cancer TherapeuticsHome page
S.-O. Yoon, S. Shin, H.-J. Lee, H.-K. Chun, and A.-S. Chung
Isoginkgetin inhibits tumor cell invasion by regulating phosphatidylinositol 3-kinase/Akt-dependent matrix metalloproteinase-9 expression.
Mol. Cancer Ther., November 1, 2006; 5(11): 2666 - 2675.
[Abstract] [Full Text] [PDF]

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 Mol Cancer ResHome page
W.-S. Wu, R. K. Tsai, C. H. Chang, S. Wang, J.-R. Wu, and Y.-X. Chang
Reactive Oxygen Species Mediated Sustained Activation of Protein Kinase C {alpha} and Extracellular Signal-Regulated Kinase for Migration of Human Hepatoma Cell Hepg2
Mol. Cancer Res., October 1, 2006; 4(10): 747 - 758.
[Abstract] [Full Text] [PDF]

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 JCBHome page
S. Osmanagic-Myers, M. Gregor, G. Walko, G. Burgstaller, S. Reipert, and G. Wiche
Plectin-controlled keratin cytoarchitecture affects MAP kinases involved in cellular stress response and migration
J. Cell Biol., August 14, 2006; 174(4): 557 - 568.
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K. Amagasaki, H. Kaneto, C.-H. Heldin, and J. Lennartsson
c-Jun N-terminal Kinase Is Necessary for Platelet-derived Growth Factor-mediated Chemotaxis in Primary Fibroblasts
J. Biol. Chem., August 4, 2006; 281(31): 22173 - 22179.
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M. Ding, R. Feng, S. Y. Wang, L. Bowman, Y. Lu, Y. Qian, V. Castranova, B.-H. Jiang, and X. Shi
Cyanidin-3-glucoside, a Natural Product Derived from Blackberry, Exhibits Chemopreventive and Chemotherapeutic Activity
J. Biol. Chem., June 23, 2006; 281(25): 17359 - 17368.
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M. J. Williams, M.-L. Wiklund, S. Wikman, and D. Hultmark
Rac1 signalling in the Drosophila larval cellular immune response
J. Cell Sci., May 15, 2006; 119(10): 2015 - 2024.
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 Mol. Cell. Biol.Home page
M. G. H. Scott, V. Pierotti, H. Storez, E. Lindberg, A. Thuret, O. Muntaner, C. Labbe-Jullie, J. A. Pitcher, and S. Marullo
Cooperative Regulation of Extracellular Signal-Regulated Kinase Activation and Cell Shape Change by Filamin A and {beta}-Arrestins.
Mol. Cell. Biol., May 1, 2006; 26(9): 3432 - 3445.
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 J. Lipid Res.Home page
N. Dronadula, F. Rizvi, E. Blaskova, Q. Li, and G. N. Rao
Involvement of cAMP-response element binding protein-1 in arachidonic acid-induced vascular smooth muscle cell motility
J. Lipid Res., April 1, 2006; 47(4): 767 - 777.
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 Circ. Res.Home page
L. H. Romer, K. G. Birukov, and J. G.N. Garcia
Focal Adhesions: Paradigm for a Signaling Nexus
Circ. Res., March 17, 2006; 98(5): 606 - 616.
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 Proc. Natl. Acad. Sci. USAHome page
C. S. Collins, J. Hong, L. Sapinoso, Y. Zhou, Z. Liu, K. Micklash, P. G. Schultz, and G. M. Hampton
A small interfering RNA screen for modulators of tumor cell motility identifies MAP4K4 as a promigratory kinase.
PNAS, March 7, 2006; 103(10): 3775 - 3780.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
T. Takino, M. Nakada, H. Miyamori, Y. Watanabe, T. Sato, D. Gantulga, K. Yoshioka, K. M. Yamada, and H. Sato
JSAP1/JIP3 Cooperates with Focal Adhesion Kinase to Regulate c-Jun N-terminal Kinase and Cell Migration
J. Biol. Chem., November 11, 2005; 280(45): 37772 - 37781.
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 Am. J. Pathol.Home page
M. Kobel, G. Pohl, W. D. Schmitt, S. Hauptmann, T.-L. Wang, and I.-M. Shih
Activation of Mitogen-Activated Protein Kinase Is Required for Migration and Invasion of Placental Site Trophoblastic Tumor
Am. J. Pathol., September 1, 2005; 167(3): 879 - 885.
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 Arterioscler. Thromb. Vasc. Bio.Home page
H. Ohtsu, M. Mifune, G. D. Frank, S. Saito, T. Inagami, S. Kim-Mitsuyama, Y. Takuwa, T. Sasaki, J. D. Rothstein, H. Suzuki, et al.
Signal-Crosstalk Between Rho/ROCK and c-Jun NH2-Terminal Kinase Mediates Migration of Vascular Smooth Muscle Cells Stimulated by Angiotensin II
Arterioscler Thromb Vasc Biol, September 1, 2005; 25(9): 1831 - 1836.
[Abstract] [Full Text] [PDF]

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M. Ebisuya, K. Kondoh, and E. Nishida
The duration, magnitude and compartmentalization of ERK MAP kinase activity: mechanisms for providing signaling specificity
J. Cell Sci., July 15, 2005; 118(14): 2997 - 3002.
[Abstract] [Full Text] [PDF]

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 BioinformaticsHome page
S. Hautaniemi, S. Kharait, A. Iwabu, A. Wells, and D. A. Lauffenburger
Modeling of signal-response cascades using decision tree analysis
Bioinformatics, May 1, 2005; 21(9): 2027 - 2035.
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 Cancer Res.Home page
P. Timpson, D. K. Lynch, D. Schramek, F. Walker, and R. J. Daly
Cortactin Overexpression Inhibits Ligand-Induced Down-regulation of the Epidermal Growth Factor Receptor
Cancer Res., April 15, 2005; 65(8): 3273 - 3280.
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