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First published online 16 November 2004
doi: 10.1242/jcs.01523

Journal of Cell Science 117, 6043-6051 (2004)
Published by The Company of Biologists 2004
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Research Article

The human histone gene expression regulator HBP/SLBP is required for histone and DNA synthesis, cell cycle progression and cell proliferation in mitotic cells

Xiujie Zhao, Susan McKillop-Smith and Berndt Müller*

School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK

* Author for correspondence (e-mail: b.mueller{at}abdn.ac.uk)

Accepted 2 September 2004

Histone proteins are essential for chromatin formation, and histone gene expression is coupled to DNA synthesis. In metazoans, the histone RNA binding protein HBP/SLBP is involved in post-transcriptional control of histone gene expression. In vitro assays have demonstrated that human HBP/SLBP is involved in histone mRNA 3' end formation and translation. We have inhibited human HBP/SLBP expression by RNA interference to determine its function during the mitotic cell cycle. Inhibition of HBP/SLBP expression resulted in the inhibition of histone gene expression and DNA synthesis, the inhibition of cell cycle progression in S phase and the inhibition of cell proliferation. These findings indicate that human HBP/SLBP is essential for the coordinate synthesis of DNA and histone proteins and is required for progression through the cell division cycle.

Key words: Cell division cycle, Histone gene expression, DNA synthesis


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© The Company of Biologists Ltd 2004