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First published online June 8, 2005
doi: 10.1242/10.1242/jcs.02402

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Two novel proteins recruited by synaptonemal complex protein 1 (SYCP1) are at the centre of meiosis

Yael Costa¹, Robert Speed¹, Rupert Öllinger², Manfred Alsheimer², Colin A. Semple¹, Philippe Gautier¹, Klio Maratou^1,*, Ivana Novak³, Christer Höög³, Ricardo Benavente² and Howard J. Cooke^1,

¹ MRC Human Genetics Unit, Western General Hospital, Crewe Rd, Edinburgh, EH4 2XU, UK
² Department of Cell and Developmental Biology, Biocenter of the University of Würzburg, 97074 Würzburg, Germany
³ Center for Genomics and Bioinformatics (CGB) and Department of Cell and Molecular Biology (CMB), Karolinska Institutet, Berzelius väg 35, S-171 77 Stockholm, Sweden

Author for correspondence (e-mail: howard.cooke{at}hgu.mrc.ac.uk)

Accepted 23 March 2005

Completion of meiosis in mammals depends on the formation of the synaptonemal complex, a tripartite structure that physically links homologous chromosomes during prophase I. Several components of the synaptonemal complex are known, including constituents of the cohesin core, the axial/lateral element and the transverse filaments. No protein has previously been identified as an exclusive component of the central element. Mutations in some synaptonemal-complex proteins results in impaired meiosis. In humans, cases of male infertility have been associated with failure to build the synaptonemal complex. To search for new components of the meiotic machinery, we have used data from microarray expression profiling and found two proteins localising solely to the central element of the mammalian synaptonemal complex. These new proteins, SYCE1 and CESC1, interact with the transverse filament protein SYCP1, and their localisation to the central element appears to depend on recruitment by SYCP1. This suggests a role for SYCE1 and CESC1 in synaptonemal-complex assembly, and perhaps also stability and recombination.

Key words: Synaptonemal complex, Germ cells, Meiosis, Gametogenesis, Recombination

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