|
|
|
|
|
|
|
|
|||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | |||||
First published online July 12, 2005
doi: 10.1242/10.1242/jcs.02505
Commentary |
Department of Cell and Developmental Biology, Graduate School of Biostudies, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan
* Author for correspondence (e-mail: L50174{at}sakura.kudpc.kyoto-u.ac.jp)
ERK MAP kinase signaling plays a pivotal role in diverse cellular functions, including cell proliferation, differentiation, migration and survival. One of the central questions concerning this signaling is how activation of the same protein kinase, ERK, elicits distinct cellular outcomes. Recent progress has demonstrated that differences in the duration, magnitude and subcellular compartmentalization of ERK activity generate variations in signaling output that regulate cell fate decisions. Furthermore, several molecules have been identified as spatial, temporal or strength-controlling regulators of ERK activity. Signaling by various extracellular stimuli thus could be modulated by these regulators to give qualitative and quantitative differences in ERK activity, which are then interpreted by the cells as determinants for appropriate responses.
Key words: Cell-fate decision, Cellular response, Growth factor, MAP kinase, Signal transduction
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  M. Isoda, Y. Kanemori, N. Nakajo, S. Uchida, K. Yamashita, H. Ueno, and N. Sagata The Extracellular Signal-regulated Kinase-Mitogen-activated Protein Kinase Pathway Phosphorylates and Targets Cdc25A for SCF{beta}-TrCP-dependent Degradation for Cell Cycle Arrest Mol. Biol. Cell, April 15, 2009; 20(8): 2186 - 2195. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. P. Armstrong, C. J. Caunt, and C. A. McArdle Gonadotropin-Releasing Hormone and Protein Kinase C Signaling to ERK: Spatiotemporal Regulation of ERK by Docking Domains and Dual-Specificity Phosphatases Mol. Endocrinol., April 1, 2009; 23(4): 510 - 519. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. U. Schraufstatter, R. G. DiScipio, M. Zhao, and S. K. Khaldoyanidi C3a and C5a Are Chemotactic Factors for Human Mesenchymal Stem Cells, Which Cause Prolonged ERK1/2 Phosphorylation J. Immunol., March 15, 2009; 182(6): 3827 - 3836. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. D. Hurlbut, M. W. Kankel, and S. Artavanis-Tsakonas Nodal points and complexity of Notch-Ras signal integration PNAS, February 17, 2009; 106(7): 2218 - 2223. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Li, C. Y. Ung, X. H. Ma, B. W. Li, B. C. Low, Z. W. Cao, and Y. Z. Chen Simulation of crosstalk between small GTPase RhoA and EGFR-ERK signaling pathway via MEKK1 Bioinformatics, February 1, 2009; 25(3): 358 - 364. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Ghose, N. V. Oleinik, N. I. Krupenko, and S. A. Krupenko 10-Formyltetrahydrofolate Dehydrogenase-Induced c-Jun-NH2-Kinase Pathways Diverge at the c-Jun-NH2-Kinase Substrate Level in Cells with Different p53 Status Mol. Cancer Res., January 1, 2009; 7(1): 99 - 107. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Sen, L. Lv, N. Bello, J. J. Ireland, and G. W. Smith Cocaine- and Amphetamine-Regulated Transcript Accelerates Termination of Follicle-Stimulating Hormone-Induced Extracellularly Regulated Kinase 1/2 and Akt Activation by Regulating the Expression and Degradation of Specific Mitogen-Activated Protein Kinase Phosphatases in Bovine Granulosa Cells Mol. Endocrinol., December 1, 2008; 22(12): 2655 - 2676. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Imamura, Y. Satoh, S. Endo, and K. Takishima Analysis of Extracellular Signal-Regulated Kinase 2 Function in Neural Stem/Progenitor Cells via Nervous System-Specific Gene Disruption Stem Cells, December 1, 2008; 26(12): 3247 - 3256. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. R. Lampard, C. A. MacAlister, and D. C. Bergmann Arabidopsis Stomatal Initiation Is Controlled by MAPK-Mediated Regulation of the bHLH SPEECHLESS Science, November 14, 2008; 322(5904): 1113 - 1116. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Aranda, M. Alvarez, S. Turro, A. Laguna, and S. de la Luna Sprouty2-Mediated Inhibition of Fibroblast Growth Factor Signaling Is Modulated by the Protein Kinase DYRK1A Mol. Cell. Biol., October 1, 2008; 28(19): 5899 - 5911. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. J. Caunt, S. P. Armstrong, C. A. Rivers, M. R. Norman, and C. A. McArdle Spatiotemporal Regulation of ERK2 by Dual Specificity Phosphatases J. Biol. Chem., September 26, 2008; 283(39): 26612 - 26623. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. S. Verbeek, J. Goedhart, L. Bruinsma, R. J. Sinke, and E. A. Reits PKC{gamma} mutations in spinocerebellar ataxia type 14 affect C1 domain accessibility and kinase activity leading to aberrant MAPK signaling J. Cell Sci., July 15, 2008; 121(14): 2339 - 2349. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Komiya, N. Kurabe, K. Katagiri, M. Ogawa, A. Sugiyama, Y. Kawasaki, and F. Tashiro A Novel Binding Factor of 14-3-3{beta} Functions as a Transcriptional Repressor and Promotes Anchorage-independent Growth, Tumorigenicity, and Metastasis J. Biol. Chem., July 4, 2008; 283(27): 18753 - 18764. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Jacamo, J. Sinnett-Smith, O. Rey, R. T. Waldron, and E. Rozengurt Sequential Protein Kinase C (PKC)-dependent and PKC-independent Protein Kinase D Catalytic Activation via Gq-coupled Receptors: DIFFERENTIAL REGULATION OF ACTIVATION LOOP SER744 AND SER748 PHOSPHORYLATION J. Biol. Chem., May 9, 2008; 283(19): 12877 - 12887. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Caunt, C. A. Rivers, B. L. Conway-Campbell, M. R. Norman, and C. A. McArdle Epidermal Growth Factor Receptor and Protein Kinase C Signaling to ERK2: SPATIOTEMPORAL REGULATION OF ERK2 BY DUAL SPECIFICITY PHOSPHATASES J. Biol. Chem., March 7, 2008; 283(10): 6241 - 6252. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. W Van Tassell and M. A Munger Aliskiren for Renin Inhibition: A New Class of Antihypertensives Ann. Pharmacother., March 1, 2007; 41(3): 456 - 464. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Tresini, A. Lorenzini, C. Torres, and V. J. Cristofalo Modulation of Replicative Senescence of Diploid Human Cells by Nuclear ERK Signaling J. Biol. Chem., February 9, 2007; 282(6): 4136 - 4151. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. P. Bliss, A. M. Navratil, M. Breed, D. C. Skinner, C. M. Clay, and M. S. Roberson Signaling Complexes Associated with the Type I Gonadotropin-Releasing Hormone (GnRH) Receptor: Colocalization of Extracellularly Regulated Kinase 2 and GnRH Receptor within Membrane Rafts Mol. Endocrinol., February 1, 2007; 21(2): 538 - 549. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Ma and G. Pei beta-arrestin signaling and regulation of transcription J. Cell Sci., January 15, 2007; 120(2): 213 - 218. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Sese, M. Corominas, H. Stocker, T. I. Heino, E. Hafen, and F. Serras The Cdi/TESK1 kinase is required for Sevenless signaling and epithelial organization in the Drosophila eye J. Cell Sci., December 15, 2006; 119(24): 5047 - 5056. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-H. Lee, J.-S. Lee, S.-E. Kim, B.-S. Moon, Y.-C. Kim, S.-K. Lee, S.-K. Lee, and K.-Y. Choi Tautomycetin inhibits growth of colorectal cancer cells through p21cip/WAF1 induction via the extracellular signal-regulated kinase pathway Mol. Cancer Ther., December 1, 2006; 5(12): 3222 - 3231. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Dickinson and S. M. Keyse Diverse physiological functions for dual-specificity MAP kinase phosphatases J. Cell Sci., November 15, 2006; 119(22): 4607 - 4615. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Kim, A. L. Clark, A. Kiss, J. W. Hahn, R. Wesselschmidt, C. J. Coscia, and M. M. Belcheva {micro}- and {kappa}-Opioids Induce the Differentiation of Embryonic Stem Cells to Neural Progenitors J. Biol. Chem., November 3, 2006; 281(44): 33749 - 33760. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. T. Ho, A. J. Bardwell, S. Grewal, C. Iverson, and L. Bardwell Interacting JNK-docking Sites in MKK7 Promote Binding and Activation of JNK Mitogen-activated Protein Kinases J. Biol. Chem., May 12, 2006; 281(19): 13169 - 13179. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. D. Vrailas, D. R. Marenda, S. E. Cook, M. A. Powers, J. A. Lorenzen, L. A. Perkins, and K. Moses smoothened and thickveins regulate Moleskin/Importin 7-mediated MAP kinase signaling in the developing Drosophila eye Development, April 15, 2006; 133(8): 1485 - 1494. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Fujioka, K. Terai, R. E. Itoh, K. Aoki, T. Nakamura, S. Kuroda, E. Nishida, and M. Matsuda Dynamics of the Ras/ERK MAPK Cascade as Monitored by Fluorescent Probes J. Biol. Chem., March 31, 2006; 281(13): 8917 - 8926. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. P. G. Hayhoe, A. M. Kamal, E. Solito, R. J. Flower, D. Cooper, and M. Perretti Annexin 1 and its bioactive peptide inhibit neutrophil-endothelium interactions under flow: indication of distinct receptor involvement Blood, March 1, 2006; 107(5): 2123 - 2130. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. L. Apostol, K. Illes, J. Pallos, L. Bodai, J. Wu, A. Strand, E. S. Schweitzer, J. M. Olson, A. Kazantsev, J. L. Marsh, et al. Mutant huntingtin alters MAPK signaling pathways in PC12 and striatal cells: ERK1/2 protects against mutant huntingtin-associated toxicity Hum. Mol. Genet., January 15, 2006; 15(2): 273 - 285. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. R. Marenda, A. D. Vrailas, A. B. Rodrigues, S. Cook, M. A. Powers, J. A. Lorenzen, L. A. Perkins, and K. Moses MAP kinase subcellular localization controls both pattern and proliferation in the developing Drosophila wing Development, January 1, 2006; 133(1): 43 - 51. [Abstract] [Full Text] [PDF]
|
|
