spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

First published online 2 August 2005
doi: 10.1242/jcs.02491

Journal of Cell Science 118, 3717-3726 (2005)
Published by The Company of Biologists 2005
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
jcs.02491v1
118/16/3717    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in JCS
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Boureux, A.
Right arrow Articles by Roche, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Boureux, A.
Right arrow Articles by Roche, S.

Research Article

Abl tyrosine kinase regulates a Rac/JNK and a Rac/Nox pathway for DNA synthesis and Myc expression induced by growth factors

Anthony Boureux, Olivia Furstoss*, Valérie Simon and Serge Roche{ddagger}

CRBM, CNRS FRE2593, 1919 route de Mende, 34293 Montpellier Cedex 05, France

{ddagger} Author for correspondence (e-mail: serge.roche{at}crbm.cnrs.fr)

Accepted 13 May 2005

The cytoplasmic tyrosine kinase Abl is a Src substrate required for platelet-derived growth factor (PDGF) receptor signaling leading to Myc expression and DNA synthesis. Abl targets are, however, ill defined. Here we report that the small GTPase Rac is an important effector of its mitogenic function. PDGF-induced Rac activation was impaired in cells with inactive Abl and active Rac overcame the mitogenic defects found in these cells. Rac function required both a Jun N-terminal kinase (JNK) and a NADPH oxidase (Nox) pathway. Furthermore, co-activation of JNK and Nox were sufficient to mimic the Rac mitogenic rescue. Abl also regulated PDGF-induced JNK and Nox activation. Finally, we found that Myc is an important target of this signaling cascade: Myc induction was sensitive to small inhibitors of JNK and Nox activities and forced expression of Myc overcame the G1 block induced by dominant interfering mutants of mitogen-activated protein kinase kinase 4 (MKK4) and Nox2 activating subunit. We concluded that cytoplasmic Abl operates on a Rac/JNK and a Rac/Nox pathway for PDGF-induced Myc induction and DNA synthesis.

Key words: Src, Abl, PDGF Receptor, Rac, Mitogenesis, Signaling


Related articles in JCS:

Abl to take the Myc in mitogenesis

JCS 2005 118: 1604. [Full Text]  



This article has been cited by other articles:


Home page
 J. Cell Sci.Home page
S. Mitra, C. Beach, G.-S. Feng, and R. Plattner
SHP-2 is a novel target of Abl kinases during cell proliferation
J. Cell Sci., October 15, 2008; 121(20): 3335 - 3346.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Biol.Home page
L. Veracini, V. Simon, V. Richard, B. Schraven, V. Horejsi, S. Roche, and C. Benistant
The Csk-binding protein PAG regulates PDGF-induced Src mitogenic signaling via GM1
J. Cell Biol., August 11, 2008; 182(3): 603 - 614.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. J. Gu, N. Zhang, Y.-W. He, A. J. Koleske, and A. M. Pendergast
Defective T Cell Development and Function in the Absence of Abelson Kinases
J. Immunol., December 1, 2007; 179(11): 7334 - 7343.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
G. Collin, M. Franco, V. Simon, C. Benistant, and S. Roche
The Tom1L1-Clathrin Heavy Chain Complex Regulates Membrane Partitioning of the Tyrosine Kinase Src Required for Mitogenic and Transforming Activities
Mol. Cell. Biol., November 1, 2007; 27(21): 7631 - 7640.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
L. Veracini, M. Franco, A. Boureux, V. Simon, S. Roche, and C. Benistant
Two distinct pools of Src family tyrosine kinases regulate PDGF-induced DNA synthesis and actin dorsal ruffles
J. Cell Sci., July 15, 2006; 119(14): 2921 - 2934.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
R. E. Clempus and K. K. Griendling
Reactive oxygen species signaling in vascular smooth muscle cells
Cardiovasc Res, July 15, 2006; 71(2): 216 - 225.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
M. Franco, O. Furstoss, V. Simon, C. Benistant, W. J. Hong, and S. Roche
The Adaptor Protein Tom1L1 Is a Negative Regulator of Src Mitogenic Signaling Induced by Growth Factors.
Mol. Cell. Biol., March 1, 2006; 26(5): 1932 - 1947.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2005