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First published online August 29, 2005
doi: 10.1242/10.1242/jcs.02524

Journal of Cell Science 118, 4039-4048 (2005)
Published by The Company of Biologists 2005
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Research Article

Roles of ARFRP1 (ADP-ribosylation factor-related protein 1) in post-Golgi membrane trafficking

Hye-Won Shin1,2,*, Hiromi Kobayashi2,*, Masashi Kitamura1, Satoshi Waguri3, Tatsuo Suganuma4, Yasuo Uchiyama3 and Kazuhisa Nakayama1,{ddagger}

1 Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan
2 Laboratory of Molecular Biology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa, Ishikawa 920-0934, Japan
3 Department of Cell Biology and Neuroscience, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan
4 Department of Anatomy, Faculty of Medicine, University of Miyazaki, Kiyotake, Miyazaki 889-1692, Japan

{ddagger} Author for correspondence (e-mail: kazunaka{at}pharm.kyoto-u.ac.jp)

Accepted 7 June 2005

ADP-ribosylation factor (ARF)-related protein 1 (ARFRP1) is a small GTPase with significant similarity to the ARF family. However, little is known about the function of ARFRP1 in mammalian cells, although knockout mice of its gene are embryonic lethal. In the present study, we demonstrate that ARFRP1 is associated mainly with the trans-Golgi compartment and the trans-Golgi network (TGN) and is an essential regulatory factor for targeting of Arl1 and GRIP domain-containing proteins, golgin-97 and golgin-245, onto Golgi membranes. Furthermore, we show that, in concert with Arl1 and GRIP proteins, ARFRP1 is implicated in the Golgi-to-plasma membrane transport of the vesicular stomatitis virus G protein as well as in the retrograde transport of TGN38 and Shiga toxin from endosomes to the TGN.

Key words: ARFRP1, Arl1, Golgin, TGN38, Shiga toxin, VSVG




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