spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

First published online August 29, 2005
doi: 10.1242/10.1242/jcs.02524

Journal of Cell Science 118, 4039-4048 (2005)
Published by The Company of Biologists 2005
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplementary Material
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Shin, H.-W.
Right arrow Articles by Nakayama, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Shin, H.-W.
Right arrow Articles by Nakayama, K.
Right arrowPubmed/NCBI databases
*Domain*Gene
*GEO Profiles*HomoloGene
*Protein*UniGene
*Compound via MeSH
*Substance via MeSH
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Research Article

Roles of ARFRP1 (ADP-ribosylation factor-related protein 1) in post-Golgi membrane trafficking

Hye-Won Shin1,2,*, Hiromi Kobayashi2,*, Masashi Kitamura1, Satoshi Waguri3, Tatsuo Suganuma4, Yasuo Uchiyama3 and Kazuhisa Nakayama1,{ddagger}

1 Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan
2 Laboratory of Molecular Biology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa, Ishikawa 920-0934, Japan
3 Department of Cell Biology and Neuroscience, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan
4 Department of Anatomy, Faculty of Medicine, University of Miyazaki, Kiyotake, Miyazaki 889-1692, Japan

{ddagger} Author for correspondence (e-mail: kazunaka{at}pharm.kyoto-u.ac.jp)

Accepted 7 June 2005

ADP-ribosylation factor (ARF)-related protein 1 (ARFRP1) is a small GTPase with significant similarity to the ARF family. However, little is known about the function of ARFRP1 in mammalian cells, although knockout mice of its gene are embryonic lethal. In the present study, we demonstrate that ARFRP1 is associated mainly with the trans-Golgi compartment and the trans-Golgi network (TGN) and is an essential regulatory factor for targeting of Arl1 and GRIP domain-containing proteins, golgin-97 and golgin-245, onto Golgi membranes. Furthermore, we show that, in concert with Arl1 and GRIP proteins, ARFRP1 is implicated in the Golgi-to-plasma membrane transport of the vesicular stomatitis virus G protein as well as in the retrograde transport of TGN38 and Shiga toxin from endosomes to the TGN.

Key words: ARFRP1, Arl1, Golgin, TGN38, Shiga toxin, VSVG


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
A. Saitoh, H.-W. Shin, A. Yamada, S. Waguri, and K. Nakayama
Three Homologous ArfGAPs Participate in Coat Protein I-mediated Transport
J. Biol. Chem., May 15, 2009; 284(20): 13948 - 13957.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. Nishimoto-Morita, H.-W. Shin, H. Mitsuhashi, M. Kitamura, Q. Zhang, L. Johannes, and K. Nakayama
Differential Effects of Depletion of ARL1 and ARFRP1 on Membrane Trafficking between the trans-Golgi Network and Endosomes
J. Biol. Chem., April 17, 2009; 284(16): 10583 - 10592.
[Abstract] [Full Text] [PDF]

Home page
 J Exp BotHome page
B. Yuksel and A. R. Memon
Comparative phylogenetic analysis of small GTP-binding genes of model legume plants and assessment of their roles in root nodules
J. Exp. Bot., October 9, 2008; (2008) ern223v1.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. Zahn, A. Jaschke, J. Weiske, A. Hommel, D. Hesse, R. Augustin, L. Lu, W. Hong, S. Florian, A. Scheepers, et al.
ADP-ribosylation Factor-like GTPase ARFRP1 Is Required for Trans-Golgi to Plasma Membrane Trafficking of E-cadherin
J. Biol. Chem., October 3, 2008; 283(40): 27179 - 27188.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
S. Y. Dejgaard, A. Murshid, A. Erman, O. Kizilay, D. Verbich, R. Lodge, K. Dejgaard, T. B. N. Ly-Hartig, R. Pepperkok, J. C. Simpson, et al.
Rab18 and Rab43 have key roles in ER-Golgi trafficking
J. Cell Sci., August 15, 2008; 121(16): 2768 - 2781.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
R. Ishizaki, H.-W. Shin, H. Mitsuhashi, and K. Nakayama
Redundant Roles of BIG2 and BIG1, Guanine-Nucleotide Exchange Factors for ADP-Ribosylation Factors in Membrane Traffic between the trans-Golgi Network and Endosomes
Mol. Biol. Cell, June 1, 2008; 19(6): 2650 - 2660.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
I. Hofmann and S. Munro
An N-terminally acetylated Arf-like GTPase is localised to lysosomes and affects their motility
J. Cell Sci., April 15, 2006; 119(8): 1494 - 1503.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2005