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First published online September 22, 2005
doi: 10.1242/10.1242/jcs.02619
Commentary |
Department of Molecular Biology, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel
* Author for correspondence (e-mail: hanita{at}cc.huji.ac.il)
Accepted 8 August 2005
mazEF is a toxin-antitoxin module located on the Escherichia coli chromosome and that of some other bacteria, including pathogens. mazF specifies for a stable toxin, MazF, and mazE specifies for a labile antitoxin, MazE, that antagonizes MazF. MazF is a sequence-specific mRNA endoribonuclease that initiates a programmed cell death pathway in response to various stresses. The mazEF-mediated death pathway can act as a defense mechanism that prevents the spread of bacterial phage infection, allowing bacterial populations to behave like multicellular organisms.
Key words: Programmed cell death, Bacterial toxin-antitoxins, Stressful conditions
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