spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

First published online 12 September 2006
doi: 10.1242/jcs.03187

Journal of Cell Science 119, 4088-4100 (2006)
Published by The Company of Biologists 2006
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplementary Material
Right arrow All Versions of this Article:
jcs.03187v1
119/19/4088    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Schafer, J. C.
Right arrow Articles by Yoder, B. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Schafer, J. C.
Right arrow Articles by Yoder, B. K.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Research Article

IFTA-2 is a conserved cilia protein involved in pathways regulating longevity and dauer formation in Caenorhabditis elegans

Jenny C. Schafer1, Marlene E. Winkelbauer1, Corey L. Williams1, Courtney J. Haycraft1, Renee A. Desmond2 and Bradley K. Yoder1,*

1 Department of Cell Biology, University of Alabama at Birmingham Medical Center, Birmingham, AL 35294, USA
2 Division of Biostatistics and Bioinformatics, University of Alabama at Birmingham Medical Center, Birmingham, AL 35294, USA

* Author for correspondence (e-mail: Byoder{at}uab.edu)

Accepted 25 July 2006

Defects in cilia are associated with diseases and developmental abnormalities. Proper cilia function is required for sonic hedgehog and PDGFR{alpha} signaling in mammals and for insulin-like growth factor (IGF) signaling in Caenorhabditis elegans. However, the role of cilia in these pathways remains unknown. To begin addressing this issue, we are characterizing putative cilia proteins in C. elegans that are predicted to have regulatory rather than structural functions. In this report, we characterized the novel cilia protein T28F3.6 (IFTA-2, intraflagellar transport associated protein 2), which is homologous to the mammalian Rab-like 5 protein. We found that, unlike the intraflagellar transport (IFT) genes, disruption of ifta-2 does not result in overt cilia assembly abnormalities, nor did it cause chemotaxis or osmotic avoidance defects typical of cilia mutants. Rather, ifta-2 null mutants have an extended lifespan phenotype and are defective in dauer formation. Our analysis indicates that these phenotypes result from defects in the DAF-2 (insulin-IGF-1-like) receptor signaling pathway in ciliated sensory neurons. We conclude that IFTA-2 is not a ciliogenic protein but rather is a regulator of specific cilia signaling activities. Interestingly, a mammalian IFTA-2 homolog is also found in cilia, raising the possibility that its function has been conserved during evolution.

Key words: C. elegans, Cilia, IFT, Rab-like, Insulin-IGF signaling


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 GeneticsHome page
C. Iomini, L. Li, J. M. Esparza, and S. K. Dutcher
Retrograde Intraflagellar Transport Mutants Identify Complex A Proteins With Multiple Genetic Interactions in Chlamydomonas reinhardtii
Genetics, November 1, 2009; 183(3): 885 - 896.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
C. Adhiambo, T. Blisnick, G. Toutirais, E. Delannoy, and P. Bastin
A novel function for the atypical small G protein Rab-like 5 in the assembly of the trypanosome flagellum
J. Cell Sci., March 15, 2009; 122(6): 834 - 841.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
N. J. Bialas, P. N. Inglis, C. Li, J. F. Robinson, J. D. K. Parker, M. P. Healey, E. E. Davis, C. D. Inglis, T. Toivonen, D. C. Cottell, et al.
Functional interactions between the ciliopathy-associated Meckel syndrome 1 (MKS1) protein and two novel MKS1-related (MKSR) proteins
J. Cell Sci., March 1, 2009; 122(5): 611 - 624.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
E. D. Smith, M. Tsuchiya, L. A. Fox, N. Dang, D. Hu, E. O. Kerr, E. D. Johnston, B. N. Tchao, D. N. Pak, K. L. Welton, et al.
Quantitative evidence for conserved longevity pathways between divergent eukaryotic species
Genome Res., April 1, 2008; 18(4): 564 - 570.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
S.-i. Yoshimura, J. Egerer, E. Fuchs, A. K. Haas, and F. A. Barr
Functional dissection of Rab GTPases involved in primary cilium formation
J. Cell Biol., July 24, 2007; 178(3): 363 - 369.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
G. Ou, M. Koga, O. E. Blacque, T. Murayama, Y. Ohshima, J. C. Schafer, C. Li, B. K. Yoder, M. R. Leroux, and J. M. Scholey
Sensory Ciliogenesis in Caenorhabditis elegans: Assignment of IFT Components into Distinct Modules Based on Transport and Phenotypic Profiles
Mol. Biol. Cell, May 1, 2007; 18(5): 1554 - 1569.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2006