|
|
|
|
|
|
|
|
|||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | |||||
First published online October 30, 2006
doi: 10.1242/10.1242/jcs.03242
Commentary |
1 Centre for Biochemistry and Molecular Cell Biology, University of Göttingen, Humboldtallee 23, 37073 Göttingen, Germany
2 Max-Planck-Institute for Experimental Medicine, Hermann-Rein-Str. 3, 37075 Göttingen, Germany
* Author for correspondence (e-mail: msimons{at}gwdg.de)
Accepted 6 September 2006
During the development of the central nervous system the reciprocal communication between neurons and oligodendrocytes is essential for the generation of myelin, a multilamellar insulating membrane that ensheathes the axons. Neuron-derived signalling molecules regulate the proliferation, differentiation and survival of oligodendrocytes. Furthermore, neurons control the onset and timing of myelin membrane growth. In turn, signals from oligodendrocytes to neurons direct the assembly of specific subdomains in neurons at the node of Ranvier. Recent work has begun to shed light on the molecules and signaling systems used to coordinate the interaction of neurons and oligodendrocytes. For example, the neuronal signals seem to control the membrane trafficking machinery in oligodendrocytes that leads to myelination. These interconnections at multiple levels show how neurons and glia cooperate to build a complex network during development.
Key words: Neurons, Oligodendrocytes, Myelin
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  P. L. Follett, C. Roth, D. Follett, and O. Dammann White Matter Damage Impairs Adaptive Recovery More Than Cortical Damage in an In Silico Model of Activity-Dependent Plasticity J Child Neurol, September 1, 2009; 24(9): 1205 - 1211. [Abstract] [PDF]
|
|
|
|
 |
|
 C. S. Barros, T. Nguyen, K. S. R. Spencer, A. Nishiyama, H. Colognato, and U. Muller {beta}1 integrins are required for normal CNS myelination and promote AKT-dependent myelin outgrowth Development, August 15, 2009; 136(16): 2717 - 2724. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Nakayama, Y. Suzuki, and I. Yazawa Microtubule Depolymerization Suppresses {alpha}-Synuclein Accumulation in a Mouse Model of Multiple System Atrophy Am. J. Pathol., April 1, 2009; 174(4): 1471 - 1480. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Schaefer and C. Brosamle Zwilling-A and -B, Two Related Myelin Proteins of Teleosts, Which Originate from a Single Bicistronic Transcript Mol. Biol. Evol., March 1, 2009; 26(3): 495 - 499. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. C. Knickmeyer, S. Gouttard, C. Kang, D. Evans, K. Wilber, J. K. Smith, R. M. Hamer, W. Lin, G. Gerig, and J. H. Gilmore A Structural MRI Study of Human Brain Development from Birth to 2 Years J. Neurosci., November 19, 2008; 28(47): 12176 - 12182. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Winterstein, J. Trotter, and E.-M. Kramer-Albers Distinct endocytic recycling of myelin proteins promotes oligodendroglial membrane remodeling J. Cell Sci., March 15, 2008; 121(6): 834 - 842. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Meikle, D. M. Talos, H. Onda, K. Pollizzi, A. Rotenberg, M. Sahin, F. E. Jensen, and D. J. Kwiatkowski A Mouse Model of Tuberous Sclerosis: Neuronal Loss of Tsc1 Causes Dysplastic and Ectopic Neurons, Reduced Myelination, Seizure Activity, and Limited Survival J. Neurosci., May 23, 2007; 27(21): 5546 - 5558. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Kippert, K. Trajkovic, L. Rajendran, J. Ries, and M. Simons Rho Regulates Membrane Transport in the Endocytic Pathway to Control Plasma Membrane Specialization in Oligodendroglial Cells J. Neurosci., March 28, 2007; 27(13): 3560 - 3570. [Abstract] [Full Text] [PDF]
|
|
