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First published online November 8, 2006
doi: 10.1242/10.1242/jcs.03247
Commentary |
1 Department of Biomedical Science and Biotechnology, Firth Court, Western Bank, University of Sheffield, Sheffield, S10 2TN, UK
2 Department of Molecular Biology and Biotechnology, Firth Court, Western Bank, University of Sheffield, Sheffield, S10 2TN, UK
* Author for correspondence (e-mail: k.ayscough{at}sheffield.ac.uk)
Accepted 6 September 2006
Increasing evidence from a variety of cell types has highlighted the importance of the actin cytoskeleton during endocytosis. No longer is actin viewed as a passive barrier that must be removed to allow endocytosis to proceed. Rather, actin structures are dynamically organised to assist the remodelling of the cell surface to allow inward movement of vesicles. The majority of our mechanistic insight into the role of actin in endocytosis has come from studies in budding yeast. Although endocytosis in mammalian cells is clearly more complex and subject to a greater array of regulatory signals, recent advances have revealed actin, and actin-regulatory proteins, to be present at endocytic sites. Furthermore, live cell imaging indicates that spatiotemporal aspects of actin recruitment and vesicle formation are likely to be conserved across eukaryotic evolution.
Key words: Clathrin, Budding yeast, Vesicle trafficking
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