QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

First published online 31 October 2006
doi: 10.1242/jcs.03261

This Article Figures Only Full Text Full Text (PDF) Supplementary Material All Versions of this Article: jcs.03261v1 119/22/4710    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Celton-Morizur, S. Articles by Paoletti, A. Search for Related Content PubMed PubMed Citation Articles by Celton-Morizur, S. Articles by Paoletti, A. Social Bookmarking                         What's this?

Pom1 kinase links division plane position to cell polarity by regulating Mid1p cortical distribution

Séverine Celton-Morizur^*, Victor Racine, Jean-Baptiste Sibarita and Anne Paoletti

Institut Curie, Centre de Recherche and CNRS UMR144, Paris, 75248 cedex 05, France

Author for correspondence (e-mail: paoletti{at}curie.fr)

Accepted 15 September 2006

In fission yeast, Mid1p, a major determinant for division plane position, defines a medial cortical compartment where it recruits myosin II at the onset of mitosis to initiate contractile ring assembly. How Mid1p is restricted to the medial cortex is unknown. We report here that in a pom1 polarity mutant, which displays a monopolar growth pattern, Mid1p distribution expands towards the non-growing cell tip, uncoupling Mid1p localization from nuclear position. This accounts for the displacement of the contractile ring during mitosis. By contrast, Mid1p localization is normal in a bud6 strain, indicating that Mid1p misdistribution is not a general consequence of monopolar growth. We conclude that Pom1 kinase acts as a negative regulator of Mid1p distribution, excluding Mid1p from non-growing ends, whereas a Pom1-independent mechanism prevents Mid1p association with growing ends. Our work therefore provides evidence that cell polarity regulators influence the distribution of Mid1p, linking division plane position to cell polarity.

Key words: Cell division, Cytokinesis, Cell polarity, Cytoskeleton

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				F. Chang and S. G. Martin Shaping Fission Yeast with Microtubules Cold Spring Harb Perspect Biol, July 1, 2009; 1(1): a001347 - a001347. [Abstract] [Full Text] [PDF]

				P. Paolo D'Avino How to scaffold the contractile ring for a safe cytokinesis - lessons from Anillin-related proteins J. Cell Sci., April 15, 2009; 122(8): 1071 - 1079. [Abstract] [Full Text] [PDF]

				S. Oliferenko, T. G. Chew, and M. K. Balasubramanian Positioning cytokinesis Genes & Dev., March 15, 2009; 23(6): 660 - 674. [Abstract] [Full Text] [PDF]

				O. Hachet and V. Simanis Mid1p/anillin and the septation initiation network orchestrate contractile ring assembly for cytokinesis Genes & Dev., November 15, 2008; 22(22): 3205 - 3216. [Abstract] [Full Text] [PDF]

				S. Castagnetti, B. Novak, and P. Nurse Microtubules offset growth site from the cell centre in fission yeast J. Cell Sci., July 1, 2007; 120(13): 2205 - 2213. [Abstract] [Full Text] [PDF]