|
|
|
|
|
|
|
|
|||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | |||||
First published online January 27, 2006
doi: 10.1242/10.1242/jcs.02826
Commentary |
Department of Molecular, Cellular and Developmental Biology, University of Michigan, Natural Science Building, Ann Arbor, MI 48109-1048, USA
* Author for correspondence (e-mail: cadigan{at}umich.edu)
Accepted 5 December 2005
Wnts are secreted proteins that are essential for a wide array of developmental and physiological processes. They signal across the plasma membrane by interacting with serpentine receptors of the Frizzled (Fz) family and members of the low-density-lipoprotein-related protein (LRP) family. Activation of Fz-LRP promotes the stability and nuclear localization of ß-catenin by compromising the ability of a multiprotein complex containing axin, adenomatosis polyposis coli (APC) and glycogen synthase kinase 3 (GSK3) to target it for degradation and block its nuclear import. The Fz-LRP receptor complex probably accomplishes this by generating multiple signals in the cytoplasm. These involve activation of Dishevelled (Dsh), possibly through trimeric G proteins and LRP-mediated axin binding and/or degradation. However, individual Wnts and Fzs can activate both ß-catenin-dependent and -independent pathways, and Fz co-receptors such as LRP probably provide some of this specificity. Additional, conflicting data concern the role of the atypical receptor tyrosine kinase Ryk, which might mediate Wnt signaling independently of Fz and/or function as a Fz co-receptor in some cells.
Key words: Wnt, Frizzled, LRP, Arrow, ß-catenin, Ryk, Dishevelled, Dvl
This article has been cited by other articles:
|
|
 |
|
  F.-Q. Li, A. Mofunanya, K. Harris, and K.-I. Takemaru Chibby cooperates with 14-3-3 to regulate {beta}-catenin subcellular distribution and signaling activity J. Cell Biol., June 30, 2008; 181(7): 1141 - 1154. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. D. Palmer, N. L. Barbosa-Morais, E. L. Gooding, B. Muralidhar, C. M. Thornton, M. R. Pett, I. Roberts, D. T. Schneider, N. Thorne, S. Tavare, et al. Pediatric Malignant Germ Cell Tumors Show Characteristic Transcriptome Profiles Cancer Res., June 1, 2008; 68(11): 4239 - 4247. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Hendriksen, M. Jansen, C. M. Brown, H. van der Velde, M. van Ham, N. Galjart, G. J. Offerhaus, F. Fagotto, and M. Fornerod Plasma membrane recruitment of dephosphorylated {beta}-catenin upon activation of the Wnt pathway J. Cell Sci., June 1, 2008; 121(11): 1793 - 1802. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Bovolenta, P. Esteve, J. M. Ruiz, E. Cisneros, and J. Lopez-Rios Beyond Wnt inhibition: new functions of secreted Frizzled-related proteins in development and disease J. Cell Sci., March 15, 2008; 121(6): 737 - 746. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Peng, Z. Yan, Y. Zhu, and J. Li Regulation of the Arabidopsis GSK3-like Kinase BRASSINOSTEROID-INSENSITIVE 2 through Proteasome-Mediated Protein Degradation Mol Plant, March 1, 2008; 1(2): 338 - 346. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. S. Parker, Y. Y. Ni, J. L. Chang, J. Li, and K. M. Cadigan Wingless Signaling Induces Widespread Chromatin Remodeling of Target Loci Mol. Cell. Biol., March 1, 2008; 28(5): 1815 - 1828. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Hongisto, J. C. Vainio, R. Thompson, M. J. Courtney, and E. T. Coffey The Wnt Pool of Glycogen Synthase Kinase 3{beta} Is Critical for Trophic-Deprivation-Induced Neuronal Death Mol. Cell. Biol., March 1, 2008; 28(5): 1515 - 1527. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P-M Chiang, R-H Yuan, H-C Hsu, T-L Mao, R-H Hu, P-L Lai, and Y-M Jeng Frequent nuclear expression of {beta}-catenin protein but rare {beta}-catenin mutation in pulmonary sclerosing haemangioma J. Clin. Pathol., March 1, 2008; 61(3): 268 - 271. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Ortega-Paino, J. Fransson, S. Ek, and C. A. K. Borrebaeck Functionally associated targets in mantle cell lymphoma as defined by DNA microarrays and RNA interference Blood, February 1, 2008; 111(3): 1617 - 1624. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Zeng, H. Huang, K. Tamai, X. Zhang, Y. Harada, C. Yokota, K. Almeida, J. Wang, B. Doble, J. Woodgett, et al. Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions Development, January 15, 2008; 135(2): 367 - 375. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Y. DAO, X. YANG, D. CHEN, M. ZUSCIK, and R. J. O'KEEFE Axin1 and Axin2 Are Regulated by TGF- and Mediate Cross-talk between TGF- and Wnt Signaling Pathways Ann. N.Y. Acad. Sci., November 1, 2007; 1116(1): 82 - 99. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Kitagawa, W. J. Ray, H. Glantschnig, P. V. Nantermet, Y. Yu, C.-T. Leu, S.-i. Harada, S. Kato, and L. P. Freedman A Regulatory Circuit Mediating Convergence between Nurr1 Transcriptional Regulation and Wnt Signaling Mol. Cell. Biol., November 1, 2007; 27(21): 7486 - 7496. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Yoshida, T. Shimomura, T. Sakabe, K. Ishii, K. Gonda, S. Matsuoka, Y. Watanabe, K. Takubo, H. Tsuchiya, Y. Hoshikawa, et al. A role of Wnt/beta-catenin signals in hepatic fate specification of human umbilical cord blood-derived mesenchymal stem cells Am J Physiol Gastrointest Liver Physiol, November 1, 2007; 293(5): G1089 - G1098. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. L. Daugherty and C. J. Gottardi Phospho-regulation of {beta}-Catenin Adhesion and Signaling Functions Physiology, October 1, 2007; 22(5): 303 - 309. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Y. Sokol and K. A. Wharton Jr WNTers in La Jolla Development, October 1, 2007; 134(19): 3393 - 3399. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Aguilera, C. Pena, J. M. Garcia, M. J. Larriba, P. Ordonez-Moran, D. Navarro, A. Barbachano, I. Lopez de Silanes, E. Ballestar, M. F. Fraga, et al. The Wnt antagonist DICKKOPF-1 gene is induced by 1{alpha},25-dihydroxyvitamin D3 associated to the differentiation of human colon cancer cells Carcinogenesis, September 1, 2007; 28(9): 1877 - 1884. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. E. Harris and S. K. Beckendorf Different Wnt signals act through the Frizzled and RYK receptors during Drosophila salivary gland migration Development, June 1, 2007; 134(11): 2017 - 2025. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Zanardi, L. Giorgetti, O. A. Botrugno, S. Minucci, P. Milani, P. G. Pelicci, and R. Carbone Immunocell-array for Molecular Dissection of Multiple Signaling Pathways in Mammalian Cells Mol. Cell. Proteomics, May 1, 2007; 6(5): 939 - 947. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Dreher and J. Callis Ubiquitin, Hormones and Biotic Stress in Plants Ann. Bot., May 1, 2007; 99(5): 787 - 822. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Benzing, M. Simons, and G. Walz Wnt Signaling in Polycystic Kidney Disease J. Am. Soc. Nephrol., May 1, 2007; 18(5): 1389 - 1398. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Schneikert and J. Behrens The canonical Wnt signalling pathway and its APC partner in colon cancer development Gut, March 1, 2007; 56(3): 417 - 425. [Full Text] [PDF]
|
|
|
|
|
|
S. Hoppler and C. L. Kavanagh Wnt signalling: variety at the core J. Cell Sci., February 1, 2007; 120(3): 385 - 393. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Coudreuse and H. C. Korswagen The making of Wnt: new insights into Wnt maturation, sorting and secretion Development, January 1, 2007; 134(1): 3 - 12. [Full Text] [PDF]
|
|
|
|
 |
|
 M.-C. Su, C.-C. Wang, C.-C. Chen, R.-H. Hu, T.-H. Wang, H.-L. Kao, Y.-M. Jeng, and R.-H. Yuan Nuclear Translocation of {beta}-Catenin Protein but Absence of {beta}-Catenin and APC Mutation in Gastrointestinal Carcinoid Tumor Ann. Surg. Oncol., December 1, 2006; 13(12): 1604 - 1609. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Bovolenta, J. Rodriguez, and P. Esteve Frizzled/RYK mediated signalling in axon guidance Development, November 15, 2006; 133(22): 4399 - 4408. [Full Text] [PDF]
|
|
|
|
|
|
A. Sato, D. K. Khadka, W. Liu, R. Bharti, L. W. Runnels, I. B. Dawid, and R. Habas Profilin is an effector for Daam1 in non-canonical Wnt signaling and is required for vertebrate gastrulation Development, November 1, 2006; 133(21): 4219 - 4231. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Waldrop, C.-C. Chan, T. Cagatay, S. Zhang, R. Rousset, J. Mack, W. Zeng, M. Fish, M. Zhang, M. Amanai, et al. An Unconventional Nuclear Localization Motif Is Crucial for Function of the Drosophila Wnt/Wingless Antagonist Naked Cuticle Genetics, September 1, 2006; 174(1): 331 - 348. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Ahmad-Annuar, L. Ciani, I. Simeonidis, J. Herreros, N. B. Fredj, S. B. Rosso, A. Hall, S. Brickley, and P. C. Salinas Signaling across the synapse: a role for Wnt and Dishevelled in presynaptic assembly and neurotransmitter release J. Cell Biol., July 3, 2006; 174(1): 127 - 139. [Abstract] [Full Text] [PDF]
|
|
