spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

First published online 17 January 2006
doi: 10.1242/jcs.02769

Journal of Cell Science 119, 482-489 (2006)
Published by The Company of Biologists 2006
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplementary Material
Right arrow All Versions of this Article:
jcs.02769v1
119/3/482    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Den, Z.
Right arrow Articles by Koch, P. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Den, Z.
Right arrow Articles by Koch, P. J.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Research Article

Desmocollin 3 is required for pre-implantation development of the mouse embryo

Zhining Den1,*, Xing Cheng1,*, Maria Merched-Sauvage1 and Peter J. Koch1,2,{ddagger}

1 Department of Dermatology, Baylor College of Medicine, Houston, TX 77030, USA
2 Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA

{ddagger} Author for correspondence (e-mail: pkoch{at}bcm.tmc.edu)

Accepted 27 October 2005

Desmocollin 3 (Dsc3) is a transmembrane glycoprotein that belongs to the cadherin family of cell adhesion receptors. Together with desmoglein(s), it forms the transmembrane core of desmosomes, a multiprotein complex involved in cell adhesion, organization of the cytoskeleton, cell sorting and cell signaling. Previous reports have suggested that Dsc3 synthesis is largely restricted to stratified epithelia, and that it plays a role in the proper differentiation of these tissues during mammalian embryonic development. To test these hypotheses, we generated Dsc3-null mice. Unexpectedly, homozygous mutants show a pre-implantation lethal phenotype. In fact, most mutants die even before mature desmosomes are formed in the embryo, suggesting a new and unexpected role of Dsc3 during early development.

Key words: Desmocollin 3, Desmosomal cadherin, Cell adhesion, Desmosome, Embryogenesis, Pre-implantation lethality


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 JCBHome page
S. Getsios, C. L. Simpson, S.-i. Kojima, R. Harmon, L. J. Sheu, R. L. Dusek, M. Cornwell, and K. J. Green
Desmoglein 1-dependent suppression of EGFR signaling promotes epidermal differentiation and morphogenesis
J. Cell Biol., June 29, 2009; 185(7): 1243 - 1258.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
J. Chen, Z. Den, and P. J. Koch
Loss of desmocollin 3 in mice leads to epidermal blistering
J. Cell Sci., September 1, 2008; 121(17): 2844 - 2849.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
X. Xu, C. Dong, and B. E. Vogel
Hemicentins Assemble on Diverse Epithelia in the Mouse
J. Histochem. Cytochem., February 1, 2007; 55(2): 119 - 126.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2006