spacer gif spacer gif spacer gif spacer gif spacer gif
 QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

First published online February 8, 2006
doi: 10.1242/10.1242/jcs.02855


Journal of Cell Science 119, 605-614 (2006)
Published by The Company of Biologists 2006
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lindmo, K.
Right arrow Articles by Stenmark, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lindmo, K.
Right arrow Articles by Stenmark, H.
Right arrowPubmed/NCBI databases
*Domain*Gene
*GEO Profiles*HomoloGene
*UniGene
Social Bookmarking
 Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Commentary

Regulation of membrane traffic by phosphoinositide 3-kinases

Karine Lindmo and Harald Stenmark*

Department of Biochemistry, Norwegian Radium Hospital and University of Oslo, Montebello, N-0310 Oslo, Norway

* Author for correspondence (e-mail: stenmark{at}ulrik.uio.no)

Accepted 22 December 2005

Phosphoinositide (PI) 3-kinases control essential cellular functions such as cytoskeletal dynamics, signal transduction and membrane trafficking. FYVE, PX and PH domains mediate the binding of effector proteins to the lipid products of PI 3-kinases. Recent studies have provided significant insights into the roles of PI 3-kinases, their catalytic products and their downstream effectors in membrane trafficking. Class I and II PI 3-kinases trigger receptor-induced trafficking processes, such as phagocytosis, macropinocytosis and regulated exocytosis. Class I PI 3-kinases also function to inhibit autophagy. By contrast, class III PI 3-kinases mainly mediate receptor-independent trafficking events, which mostly are related to endocytic membrane traffic, phagosome maturation and autophagy.

Key words: Autophagy, Endocytosis, Exocytosis, Macropinocytosis, Phagocytosis, PI 3-kinase


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
JCBHome page
S. L. Edwards, N. K. Charlie, J. E. Richmond, J. Hegermann, S. Eimer, and K. G. Miller
Impaired dense core vesicle maturation in Caenorhabditis elegans mutants lacking Rab2
J. Cell Biol., September 21, 2009; 186(6): 881 - 895.
[Abstract] [Full Text] [PDF]


Home page
JCBHome page
A. Simonsen and S. A. Tooze
Coordination of membrane events during autophagy by multiple class III PI3-kinase complexes
J. Cell Biol., September 21, 2009; 186(6): 773 - 782.
[Abstract] [Full Text] [PDF]


Home page
J. Neurosci.Home page
R. Butowt and C. S. von Bartheld
Fates of Neurotrophins after Retrograde Axonal Transport: Phosphorylation of p75NTR Is a Sorting Signal for Delayed Degradation
J. Neurosci., August 26, 2009; 29(34): 10715 - 10729.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Endocrinol. Metab.Home page
J. Avruch, X. Long, S. Ortiz-Vega, J. Rapley, A. Papageorgiou, and N. Dai
Amino acid regulation of TOR complex 1
Am J Physiol Endocrinol Metab, April 1, 2009; 296(4): E592 - E602.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Pathol.Home page
R. A. Bartolome, S. Ferreiro, M. E. Miquilena-Colina, L. Martinez-Prats, M. L. Soto-Montenegro, D. Garcia-Bernal, J. J. Vaquero, R. Agami, R. Delgado, M. Desco, et al.
The Chemokine Receptor CXCR4 and the Metalloproteinase MT1-MMP Are Mutually Required during Melanoma Metastasis to Lungs
Am. J. Pathol., February 1, 2009; 174(2): 602 - 612.
[Abstract] [Full Text] [PDF]


Home page
Mol. Biol. CellHome page
E. Itakura, C. Kishi, K. Inoue, and N. Mizushima
Beclin 1 Forms Two Distinct Phosphatidylinositol 3-Kinase Complexes with Mammalian Atg14 and UVRAG
Mol. Biol. Cell, December 1, 2008; 19(12): 5360 - 5372.
[Abstract] [Full Text] [PDF]


Home page
Mol. Biol. CellHome page
P. J. Wen, S. L. Osborne, I. C. Morrow, R. G. Parton, J. Domin, and F. A. Meunier
Ca2+-regulated Pool of Phosphatidylinositol-3-phosphate Produced by Phosphatidylinositol 3-Kinase C2{alpha} on Neurosecretory Vesicles
Mol. Biol. Cell, December 1, 2008; 19(12): 5593 - 5603.
[Abstract] [Full Text] [PDF]


Home page
J. Cell Sci.Home page
D. Bonanomi, E. F. Fornasiero, G. Valdez, S. Halegoua, F. Benfenati, A. Menegon, and F. Valtorta
Identification of a developmentally regulated pathway of membrane retrieval in neuronal growth cones
J. Cell Sci., November 15, 2008; 121(22): 3757 - 3769.
[Abstract] [Full Text] [PDF]


Home page
JCBHome page
Y. Tian, C. Pate, A. Andreolotti, L. Wang, E. Tuomanen, K. Boyd, E. Claro, and S. Jackowski
Cytokine secretion requires phosphatidylcholine synthesis
J. Cell Biol., October 21, 2008; 181(6): 945 - 957.
[Abstract] [Full Text] [PDF]


Home page
JCBHome page
G. Juhasz, J. H. Hill, Y. Yan, M. Sass, E. H. Baehrecke, J. M. Backer, and T. P. Neufeld
The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila
J. Cell Biol., October 17, 2008; 181(4): 655 - 666.
[Abstract] [Full Text] [PDF]


Home page
JCBHome page
E. L. Axe, S. A. Walker, M. Manifava, P. Chandra, H. L. Roderick, A. Habermann, G. Griffiths, and N. T. Ktistakis
Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum
J. Cell Biol., August 26, 2008; 182(4): 685 - 701.
[Abstract] [Full Text] [PDF]


Home page
JCBHome page
G. V. Mallo, M. Espina, A. C. Smith, M. R. Terebiznik, A. Aleman, B. B. Finlay, L. E. Rameh, S. Grinstein, and J. H. Brumell
SopB promotes phosphatidylinositol 3-phosphate formation on Salmonella vacuoles by recruiting Rab5 and Vps34
J. Cell Biol., August 25, 2008; 182(4): 741 - 752.
[Abstract] [Full Text] [PDF]


Home page
JGPHome page
T.-M. Wang and D. W. Hilgemann
Ca-dependent Nonsecretory Vesicle Fusion in a Secretory Cell
J. Gen. Physiol., July 1, 2008; 132(1): 51 - 65.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
F. L. Robinson, I. R. Niesman, K. K. Beiswenger, and J. E. Dixon
Loss of the inactive myotubularin-related phosphatase Mtmr13 leads to a Charcot-Marie-Tooth 4B2-like peripheral neuropathy in mice
PNAS, March 25, 2008; 105(12): 4916 - 4921.
[Abstract] [Full Text] [PDF]


Home page
Infect. Immun.Home page
K. Picazarri, K. Nakada-Tsukui, and T. Nozaki
Autophagy during Proliferation and Encystation in the Protozoan Parasite Entamoeba invadens
Infect. Immun., January 1, 2008; 76(1): 278 - 288.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. ProteomicsHome page
S. Bidlingmaier and B. Liu
Interrogating Yeast Surface-displayed Human Proteome to Identify Small Molecule-binding Proteins
Mol. Cell. Proteomics, November 1, 2007; 6(11): 2012 - 2020.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
A. A. Herrada, F. J. Contreras, J. A. Tobar, R. Pacheco, and A. M. Kalergis
Immune complex-induced enhancement of bacterial antigen presentation requires Fc{gamma} Receptor III expression on dendritic cells
PNAS, August 14, 2007; 104(33): 13402 - 13407.
[Abstract] [Full Text] [PDF]


Home page
J EndocrinolHome page
E. Hirsch, C. Costa, and E. Ciraolo
Phosphoinositide 3-kinases as a common platform for multi-hormone signaling
J. Endocrinol., August 1, 2007; 194(2): 243 - 256.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
R. V. Stahelin, D. Karathanassis, K. S. Bruzik, M. D. Waterfield, J. Bravo, R. L. Williams, and W. Cho
Structural and Membrane Binding Analysis of the Phox Homology Domain of Phosphoinositide 3-Kinase-C2{alpha}
J. Biol. Chem., December 22, 2006; 281(51): 39396 - 39406.
[Abstract] [Full Text] [PDF]


Home page
J. Cell Sci.Home page
S. Falcone, E. Cocucci, P. Podini, T. Kirchhausen, E. Clementi, and J. Meldolesi
Macropinocytosis: regulated coordination of endocytic and exocytic membrane traffic events
J. Cell Sci., November 15, 2006; 119(22): 4758 - 4769.
[Abstract] [Full Text] [PDF]


Home page
Mol. Biol. CellHome page
T. E. Rusten, L. M.W. Rodahl, K. Pattni, C. Englund, C. Samakovlis, S. Dove, A. Brech, and H. Stenmark
Fab1 Phosphatidylinositol 3-Phosphate 5-Kinase Controls Trafficking but Not Silencing of Endocytosed Receptors
Mol. Biol. Cell, September 1, 2006; 17(9): 3989 - 4001.
[Abstract] [Full Text] [PDF]




© The Company of Biologists Ltd 2006