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First published online March 8, 2006
doi: 10.1242/10.1242/jcs.02893

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The return of the peroxisome

¹ Department of Cellular Protein Chemistry and Academic Biomedical Centre, Utrecht University, Padualaan 8, NL-3548 CH Utrecht, The Netherlands
² Laboratory of Cell Biology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands

^* Author for correspondence (e-mail: a.vanderzand{at}chem.uu.nl)

Accepted 18 January 2006

Of the classical compartments of eukaryotic cells, peroxisomes were the last to be discovered. They are small, single-membrane-bound vesicles involved in cellular metabolism, most notably the ß-oxidation of fatty acids. Characterization of their properties and behavior has progressed rather slowly. However, during the past few years, peroxisomes have entered the limelight as a result of several breakthroughs. These include the observations that they are not autonomously multiplying organelles but are derived from the endoplasmic reticulum, and that partitioning of peroxisomes to progeny cells is an active and well-controlled process. In addition, we are discovering more and more proteins that are not only dedicated to peroxisomes but also serve other organelles.

Key words: Peroxisomes, Peroxisome biogenesis, Endoplasmic reticulum, Organelle, Maintenance, Protein import

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