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First published online April 24, 2006
doi: 10.1242/10.1242/jcs.02963
Commentary |
Center for Basic Research in Digestive Diseases and Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
* Author for correspondence (e-mail: mcniven.mark{at}mayo.edu)
Accepted 28 February 2006
The large GTPase dynamin, long known for its role in endocytosis, has most recently been implicated as a facilitator of cell migration and invasion. Recent observations link dynamin to the cycle of membrane expansion and retraction essential for cell motility. Its role in actin polymerization, membrane deformation and vesiculation, and focal adhesion dynamics are all important for this process, and the new findings provide exciting directions for studies of this ubiquitous and diverse protein family.
Key words: Dynamin, Cell Motility, Migration, Invasion
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