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First published online April 24, 2006
doi: 10.1242/10.1242/jcs.02963

Journal of Cell Science 119, 1683-1690 (2006)
Published by The Company of Biologists 2006
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Commentary

Dynamin as a mover and pincher during cell migration and invasion

Anne E. Kruchten and Mark A. McNiven*

Center for Basic Research in Digestive Diseases and Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA

* Author for correspondence (e-mail: mcniven.mark{at}mayo.edu)

Accepted 28 February 2006

The large GTPase dynamin, long known for its role in endocytosis, has most recently been implicated as a facilitator of cell migration and invasion. Recent observations link dynamin to the cycle of membrane expansion and retraction essential for cell motility. Its role in actin polymerization, membrane deformation and vesiculation, and focal adhesion dynamics are all important for this process, and the new findings provide exciting directions for studies of this ubiquitous and diverse protein family.

Key words: Dynamin, Cell Motility, Migration, Invasion




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