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Journal of Cell Science, Vol 12, 809-830, Copyright © 1973 by Company of Biologists

Submitted on August 11, 1972

Human Chromosomes in 18 Man-Mouse Somatic Hybrid Cell Lines Analysed by Quinacrine Fluorescence

P. W. ALLDERDICE 1, O. J. MILLER 1, P. L. PEARSON 2, G. KLEIN 3, and H. HARRIS 4

1 Department of Human Genetics and Development, and Department of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, New York 10032, U.S.A.
2 M.R.C Clincal Population Genetics Unit, Headington, Oxford, England; Department of Genetics, University of Leiden, Leiden, The Netherlands
3 Department of Tumor Biology, Karolinska Institutet, S-104 01 Stockholm 60, Sweden
4 Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, England

Chromosome studies were done on 18 somatic hybrid cell lines produced by fusing cells of the mouse A 9 line with cells of the human Daudi lymphoblastoid line derived from a patient with Burkitt's lymphoma. The human chromosomes were identified by their quinacrine fluorescent banding patterns. In one hybrid line the human chromosomes were identified also by the centromeric heterochromatin staining technique. Every human chromosome was identified in one or more of the hybrid lines. Some lines were homogeneous in terms of their human chromosome content, while others were quite heterogeneous. Detailed analysis of the A 9 chromosomes in one hybrid line showed very few changes in comparison with the chromosome constitution of the average A 9 cell.

Submitted on August 11, 1972




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[Abstract] [PDF]


© The Company of Biologists Ltd 1973