|
|
|
|
|
|
|
|
|||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | |||||
First published online May 14, 2007
doi: 10.1242/10.1242/jcs.03442
Commentary |
Division of Molecular Medicine, Wadsworth Center, New York State Department of Health, Albany, NY 12201-0509, USA
e-mails: oconnell{at}wadsworth.org; khodj{at}wadsworth.org
Accepted 8 March 2007
Cooperativity is well known to promote the speed of some biochemical reactions by accelerating the activity of enzymes. Recent studies have shown that cooperative interactions also function during the formation of a complex cellular structure, the mitotic spindle. Capture of kinetochores by dynamic astral microtubules was originally proposed as the basis of spindle formation. However, mounting evidence indicates that a more complex series of events occurs. It is now clear that there are multiple microtubule nucleation and capture sites throughout the spindle. Kinetochores, centrosomes and microtubules play multiple roles in establishing connections between spindle components and integrating them into a common structure. These data support a modified search-and-capture model that incorporates additional assembly pathways coordinated by a RanGTP gradient.
Key words: Mitosis, Spindle assembly, Cell division
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  J. Dai, A. V. Kateneva, and J. M. G. Higgins Studies of haspin-depleted cells reveal that spindle-pole integrity in mitosis requires chromosome cohesion J. Cell Sci., November 15, 2009; 122(22): 4168 - 4176. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. K. Cross and M. A. Powers Learning about cancer from frogs: analysis of mitotic spindles in Xenopus egg extracts Dis. Model. Mech., November 1, 2009; 2(11-12): 541 - 547. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. B. O'Connell, J. Loncarek, P. Kalab, and A. Khodjakov Relative contributions of chromatin and kinetochores to mitotic spindle assembly J. Cell Biol., October 5, 2009; 187(1): 43 - 51. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Paul, R. Wollman, W. T. Silkworth, I. K. Nardi, D. Cimini, and A. Mogilner Computer simulations predict that chromosome movements and rotations accelerate mitotic spindle assembly without compromising accuracy PNAS, September 15, 2009; 106(37): 15708 - 15713. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. W. Chan, L. L. Fava, A. Uldschmid, M. H.A. Schmitz, D. W. Gerlich, E. A. Nigg, and A. Santamaria Mitotic control of kinetochore-associated dynein and spindle orientation by human Spindly J. Cell Biol., June 1, 2009; 185(5): 859 - 874. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. S. Rizk, K. P. Bohannon, L. A. Wetzel, J. Powers, S. L. Shaw, and C. E. Walczak MCAK and Paclitaxel Have Differential Effects on Spindle Microtubule Organization and Dynamics Mol. Biol. Cell, March 15, 2009; 20(6): 1639 - 1651. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Zhang, M. Breuer, A. Forster, D. Egger-Adam, and A. Wodarz Mars, a Drosophila protein related to vertebrate HURP, is required for the attachment of centrosomes to the mitotic spindle during syncytial nuclear divisions J. Cell Sci., February 15, 2009; 122(4): 535 - 545. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Q. Rasi, J. D.K. Parker, J. L. Feldman, W. F. Marshall, and L. M. Quarmby Katanin Knockdown Supports a Role for Microtubule Severing in Release of Basal Bodies before Mitosis in Chlamydomonas Mol. Biol. Cell, January 1, 2009; 20(1): 379 - 388. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. B. Mistry, D. E. MacCallum, R. C. Jackson, M. A. J. Chaplain, and F. A. Davidson Modeling the temporal evolution of the spindle assembly checkpoint and role of Aurora B kinase PNAS, December 23, 2008; 105(51): 20215 - 20220. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Zhu, J. A. Coppinger, C.-Y. Jang, J. R. Yates III, and G. Fang FAM29A promotes microtubule amplification via recruitment of the NEDD1-{gamma}-tubulin complex to the mitotic spindle J. Cell Biol., December 1, 2008; 183(5): 835 - 848. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. R. Barr and F. Gergely MCAK-Independent Functions of ch-Tog/XMAP215 in Microtubule Plus-End Dynamics Mol. Cell. Biol., December 1, 2008; 28(23): 7199 - 7211. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Fila, C. Metz, and P. van der Sluijs Juglone Inactivates Cysteine-rich Proteins Required for Progression through Mitosis J. Biol. Chem., August 1, 2008; 283(31): 21714 - 21724. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. W. Bird and A. A. Hyman Building a spindle of the correct length in human cells requires the interaction between TPX2 and Aurora A J. Cell Biol., July 28, 2008; 182(2): 289 - 300. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Ducat, S.-i. Kawaguchi, H. Liu, J. R. Yates III, and Y. Zheng Regulation of Microtubule Assembly and Organization in Mitosis by the AAA+ ATPase Pontin Mol. Biol. Cell, July 1, 2008; 19(7): 3097 - 3110. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. L. Sackett, L. Ozbun, E. Zudaire, L. Wessner, J. M. Chirgwin, F. Cuttitta, and A. Martinez Intracellular Proadrenomedullin-Derived Peptides Decorate the Microtubules and Contribute to Cytoskeleton Function Endocrinology, June 1, 2008; 149(6): 2888 - 2898. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Torosantucci, M. De Luca, G. Guarguaglini, P. Lavia, and F. Degrassi Localized RanGTP Accumulation Promotes Microtubule Nucleation at Kinetochores in Somatic Mammalian Cells Mol. Biol. Cell, May 1, 2008; 19(5): 1873 - 1882. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. R. Barr and F. Gergely Aurora-A: the maker and breaker of spindle poles J. Cell Sci., September 1, 2007; 120(17): 2987 - 2996. [Abstract] [Full Text] [PDF]
|
|
