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First published online 17 July 2007
doi: 10.1242/jcs.007104

Journal of Cell Science 120, 2586-2593 (2007)
Published by The Company of Biologists 2007
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Research Article

Miz1 is required for hair follicle structure and hair morphogenesis

Anneli Gebhardt1, Christian Kosan2, Barbara Herkert3, Tarik Möröy2,4, Werner Lutz3, Martin Eilers3 and Hans-Peter Elsässer1,*

1 Institute for Cell Biology, University of Marburg, Robert-Koch-Str. 6, 35033 Marburg, Germany
2 Institut de recherches cliniques de Montreal, 110 Avenue des Pins West, Montreal, QC, H2W 1R7, Canada
3 Institute for Molecular Biology and Tumor Research (IMT), University of Marburg, Emil-Mannkopff-Str.2, 35033 Marburg, Germany
4 Institut de recherches cliniques de Montreal, Department de Microbiologie et Immunologie, Université de Montréal, 110 Avenue des Pins West, Montreal, QC, H2W 1R7, Canada

* Author for correspondence (e-mail: elsaesse{at}mailer.uni-marburg.de)

Accepted 26 May 2007

Previous work has implicated the Myc-binding transcription factor Miz1 in the control of keratinocyte proliferation and in the cellular response to TGFbeta. Miz1 is expressed in basal keratinocytes of the interfollicular epidermis and in hair follicles. Here we have conditionally knocked out the POZ/BTB transactivation domain of Miz1 in keratinocytes using a keratin 14 (K14)-Cre mouse deleter strain. K14Cre+/Miz1lox/lox mice have rough fur as a result of altered hair follicle orientation, irregular hair pigmentation and disturbed hair fiber structure. A regional thickening of the epidermis at the hair funnel orifice was accompanied by suprabasal proliferation, indicating a delayed exit of keratinocytes from the cell cycle. In addition, the catagen of the hair cycle was delayed in K14Cre+/Miz1lox/lox mice and intrafollicular keratinocyte proliferation was increased. In aged K14Cre+/Miz1lox/lox animals, the number of hair follicles remained unchanged but the number of visible hairs, especially of zigzag hairs, was reduced and a pigmentary incontinence into the dermis developed. Our data show that Miz1 is involved in controlling proliferation and differentiation in hair follicles and in hair fiber morphogenesis.

Key words: Myc, Miz1, Transforming growth factor beta1, Epidermis, Hair follicle, Catagen


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