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First published online August 9, 2007
doi: 10.1242/10.1242/jcs.007633

Journal of Cell Science 120, 2755-2761 (2007)
Published by The Company of Biologists 2007
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Commentary

Transcriptional interference: an unexpected layer of complexity in gene regulation

Alexander Mazo1, Jacob W. Hodgson2, Svetlana Petruk1, Yurii Sedkov1 and Hugh W. Brock2,*

1 Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
2 Molecular Epigenetics Group, Life Sciences Institute, Department of Zoology, University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC, V6T 1Z3, Canada

* Author for correspondence (e-mail: brock{at}zoology.ubc.ca)

Accepted 25 June 2007

Much of the genome is transcribed into long untranslated RNAs, mostly of unknown function. Growing evidence suggests that transcription of sense and antisense untranslated RNAs in eukaryotes can repress a neighboring gene by a phenomenon termed transcriptional interference. Transcriptional interference by the untranslated RNA may prevent recruitment of the initiation complex or prevent transcriptional elongation. Recent work in yeast, mammals, and Drosophila highlights the diverse roles that untranslated RNAs play in development. Previously, untranslated RNAs of the bithorax complex of Drosophila were proposed to be required for its activation. Recent studies show that these untranslated RNAs in fact silence Ultrabithorax in early embryos, probably by transcriptional interference.

Key words: Drosophila, Hox, cis-acting, Repression, Untranslated RNA


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© The Company of Biologists Ltd 2007