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First published online 31 July 2007
doi: 10.1242/jcs.006551

Journal of Cell Science 120, 2924-2934 (2007)
Published by The Company of Biologists 2007
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Research Article

The fatty acid elongase NOA is necessary for viability and has a somatic role in Drosophila sperm development

Anita Jung*,{ddagger}, Martin Hollmann* and Mireille A. Schäfer§

FB18 Zoologie/Entwicklungsbiologie, Universität Kassel, Heinrich-Plett-Str. 40, 34132 Kassel, Germany and III. Zool. Institut-Entwicklungsbiologie, Humboldtallee 34A, 37073 Göttingen, Germany

§ Author for correspondence (e-mail: mirescha{at}uni-kassel.de)

Accepted 13 June 2007

The essential gene noa (CG 3971; also known as Baldspot) encodes a very long chain fatty acid elongase which is most similar to the mammalian elongase ELOVL6. noa is expressed in the nervous system from embryogenesis on, in imaginal discs, the fat body, malpighian tubules and in the gonads of both sexes. Its function is dose dependent, since reduced levels of noa RNA lead to impaired motility and severely reduced viability. In testes, noa RNA is detected in the cyst cells during the postmeiotic phase of germ cell development. An RNAi construct selectively driven in cyst cells leads to male sterility, demonstrating the necessity of noa function for male germline development and the interaction of the somatic cyst cells with the developing sperm.

Key words: Drosophila, Fatty acid elongases, Spermatogenesis, Cyst cells, RNAi, Embryogenesis


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© The Company of Biologists Ltd 2007