spacer gif spacer gif spacer gif spacer gif spacer gif
 QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

First published online September 18, 2007
doi: 10.1242/10.1242/jcs.010389


Journal of Cell Science 120, 3163-3172 (2007)
Published by The Company of Biologists 2007
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Donninger, H.
Right arrow Articles by Clark, G. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Donninger, H.
Right arrow Articles by Clark, G. J.
Social Bookmarking
 Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Commentary

The RASSF1A tumor suppressor

Howard Donninger1, Michele D. Vos2 and Geoffrey J. Clark1,*

1 Molecular Targets Group, Department of Medicine, J. G. Brown Cancer Center, University of Louisville, 119C Baxter Boulevard, 580 S. Preston Street, Louisville, KY 40202, USA
2 Research Analysis and Evaluation Branch, NCI, Rockville, MD, USA

* Author for correspondence (e-mail: gjclar01{at}louisville.edu)

Accepted 23 July 2007

RASSF1A (Ras association domain family 1 isoform A) is a recently discovered tumor suppressor whose inactivation is implicated in the development of many human cancers. Although it can be inactivated by gene deletion or point mutations, the most common contributor to loss or reduction of RASSF1A function is transcriptional silencing of the gene by inappropriate promoter methylation. This epigenetic mechanism can inactivate numerous tumor suppressors and is now recognized as a major contributor to the development of cancer.

RASSF1A lacks apparent enzymatic activity but contains a Ras association (RA) domain and is potentially an effector of the Ras oncoprotein. RASSF1A modulates multiple apoptotic and cell cycle checkpoint pathways. Current evidence supports the hypothesis that it serves as a scaffold for the assembly of multiple tumor suppressor complexes and may relay pro-apoptotic signaling by K-Ras.

Key words: Epigenetic, RASSF1A, Ras, Tumor suppressor


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
Cancer Res.Home page
D. F. Calvisi, H. Donninger, M. D. Vos, M. J. Birrer, L. Gordon, V. Leaner, and G. J. Clark
NORE1A Tumor Suppressor Candidate Modulates p21CIP1 via p53
Cancer Res., June 1, 2009; 69(11): 4629 - 4637.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
J. Avruch, R. Xavier, N. Bardeesy, X.-f. Zhang, M. Praskova, D. Zhou, and F. Xia
Rassf Family of Tumor Suppressor Polypeptides
J. Biol. Chem., April 24, 2009; 284(17): 11001 - 11005.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
S. Thaler, P. S. Hahnel, A. Schad, R. Dammann, and M. Schuler
RASSF1A Mediates p21Cip1/Waf1-Dependent Cell Cycle Arrest and Senescence through Modulation of the Raf-MEK-ERK Pathway and Inhibition of Akt
Cancer Res., March 1, 2009; 69(5): 1748 - 1757.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
D. Macheiner, C. Gauglhofer, C. Rodgarkia-Dara, M. Grusch, A. Brachner, C. Bichler, D. Kandioler, H. Sutterluty, W. Mikulits, R. Schulte-Hermann, et al.
NORE1B Is a Putative Tumor Suppressor in Hepatocarcinogenesis and May Act via RASSF1A
Cancer Res., January 1, 2009; 69(1): 235 - 242.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
S. Hoare, K. Hoare, M. K. Reinhard, Y. J. Lee, S. P. Oh, and W. S. May Jr.
Tnk1/Kos1 Knockout Mice Develop Spontaneous Tumors
Cancer Res., November 1, 2008; 68(21): 8723 - 8732.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
Y. Hao, A. Chun, K. Cheung, B. Rashidi, and X. Yang
Tumor Suppressor LATS1 Is a Negative Regulator of Oncogene YAP
J. Biol. Chem., February 29, 2008; 283(9): 5496 - 5509.
[Abstract] [Full Text] [PDF]




© The Company of Biologists Ltd 2007