QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

First published online September 18, 2007
doi: 10.1242/10.1242/jcs.010850

This Article Figures Only Full Text Full Text (PDF) Supplementary Material Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Gorfinkiel, N. Articles by Arias, A. M. Search for Related Content PubMed PubMed Citation Articles by Gorfinkiel, N. Articles by Arias, A. M. Social Bookmarking                         What's this?

Requirements for adherens junction components in the interaction between epithelial tissues during dorsal closure in Drosophila

Department of Genetics, University of Cambridge, Cambridge, CB2 3EH, UK

e-mails: ng288{at}hermes.cam.ac.uk; ama11{at}cam.ac.uk

Accepted 26 June 2007

Dynamic interactions between epithelial sheets are a regular feature of morphogenetic processes. Dorsal closure in Drosophila relies on the coordinated movements of two epithelia, the epidermis and the amnioserosa, and provides an excellent model system for a genetic and cell biological approach. Here, we have analyzed the contribution of junctional organization of these epithelia to dorsal closure. We observe a stringent requirement for adherens junctions at the leading edge, the interface between the amnioserosa and the epidermis, for the transmission of the forces generated during the process. We also find that interactions between Armadillo and E-cadherin play an important role in maintaining the adhesion at the leading edge, revealing the particular dynamics of this interface. Our results show that regulated cell adhesion is a crucial element of the interactions that shape epithelial sheets in morphogenetic processes.

Key words: Adhesion, Dynamic, Epithelia

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				N. Gorfinkiel, G. B. Blanchard, R. J. Adams, and A. Martinez Arias Mechanical control of global cell behaviour during dorsal closure in Drosophila Development, June 1, 2009; 136(11): 1889 - 1898. [Abstract] [Full Text] [PDF]

				M. Narasimha, A. Uv, A. Krejci, N. H. Brown, and S. J. Bray Grainy head promotes expression of septate junction proteins and influences epithelial morphogenesis J. Cell Sci., March 15, 2008; 121(6): 747 - 752. [Abstract] [Full Text] [PDF]