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First published online January 24, 2007
doi: 10.1242/10.1242/jcs.03363

Journal of Cell Science 120, 385-393 (2007)
Published by The Company of Biologists 2007
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Commentary

Wnt signalling: variety at the core

Stefan Hoppler* and Claire Louise Kavanagh

Institute of Medical Sciences, University of Aberdeen, Aberdeen, AB25 2ZD, UK

* Author for correspondence (e-mail: s.p.hoppler{at}abdn.ac.uk)

Accepted 27 November 2006

The Wnt/beta-catenin pathway is a conserved cell-cell signalling mechanism in animals that regulates gene expression via TCF/LEF DNA-binding factors to coordinate many cellular processes. Vertebrates normally have four Tcf/Lef genes, which, through alternative splicing and alternative promoter use give rise to a variety of TCF/LEF isoforms. Recent evidence from several experimental systems suggests that this diversity of TCF/LEF factors is functionally important in vertebrates for mediating tissue- and stage-specific Wnt regulation in embryonic development, stem cell differentiation and associated diseases, such as cancer.

Key words: Wnt, LEF, TCF, Signalling, beta-catenin, Tissue-specificity, Vertebrates, Embryonic development, Stem cells, Alternative splicing




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