spacer gif spacer gif spacer gif spacer gif Propose a workshop for 2011 spacer gif
 QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

First published online January 24, 2007
doi: 10.1242/10.1242/jcs.03363


Journal of Cell Science 120, 385-393 (2007)
Published by The Company of Biologists 2007
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hoppler, S.
Right arrow Articles by Kavanagh, C. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hoppler, S.
Right arrow Articles by Kavanagh, C. L.
Social Bookmarking
 Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Commentary

Wnt signalling: variety at the core

Stefan Hoppler* and Claire Louise Kavanagh

Institute of Medical Sciences, University of Aberdeen, Aberdeen, AB25 2ZD, UK

* Author for correspondence (e-mail: s.p.hoppler{at}abdn.ac.uk)

Accepted 27 November 2006

The Wnt/β-catenin pathway is a conserved cell-cell signalling mechanism in animals that regulates gene expression via TCF/LEF DNA-binding factors to coordinate many cellular processes. Vertebrates normally have four Tcf/Lef genes, which, through alternative splicing and alternative promoter use give rise to a variety of TCF/LEF isoforms. Recent evidence from several experimental systems suggests that this diversity of TCF/LEF factors is functionally important in vertebrates for mediating tissue- and stage-specific Wnt regulation in embryonic development, stem cell differentiation and associated diseases, such as cancer.

Key words: Wnt, LEF, TCF, Signalling, β-catenin, Tissue-specificity, Vertebrates, Embryonic development, Stem cells, Alternative splicing


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
J. Biol. Chem.Home page
S. Dennler, J. Andre, F. Verrecchia, and A. Mauviel
Cloning of the Human GLI2 Promoter: TRANSCRIPTIONAL ACTIVATION BY TRANSFORMING GROWTH FACTOR-{beta} VIA SMAD3/{beta}-CATENIN COOPERATION
J. Biol. Chem., November 13, 2009; 284(46): 31523 - 31531.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Cell Physiol.Home page
R. A. Shanely, K. A. Zwetsloot, T. E. Childs, S. J. Lees, R. W. Tsika, and F. W. Booth
IGF-I activates the mouse type IIb myosin heavy chain gene
Am J Physiol Cell Physiol, October 1, 2009; 297(4): C1019 - C1027.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. Biol.Home page
H.-S. Kwon, H.-S. Lee, Y. Ji, J. S. Rubin, and S. I. Tomarev
Myocilin Is a Modulator of Wnt Signaling
Mol. Cell. Biol., April 15, 2009; 29(8): 2139 - 2154.
[Abstract] [Full Text] [PDF]


Home page
IOVSHome page
S. Fuhrmann, A. N. Riesenberg, A. M. Mathiesen, E. C. Brown, M. L. Vetter, and N. L. Brown
Characterization of a Transient TCF/LEF-Responsive Progenitor Population in the Embryonic Mouse Retina
Invest. Ophthalmol. Vis. Sci., January 1, 2009; 50(1): 432 - 440.
[Abstract] [Full Text] [PDF]


Home page
Mol Hum ReprodHome page
H.-X. Wang, F. R. Tekpetey, and G. M. Kidder
Identification of WNT/{beta}-CATENIN signaling pathway components in human cumulus cells
Mol. Hum. Reprod., January 1, 2009; 15(1): 11 - 17.
[Abstract] [Full Text] [PDF]


Home page
Endocr Relat CancerHome page
C. Weidinger, K. Krause, A. Klagge, S. Karger, and D. Fuhrer
Forkhead box-O transcription factor: critical conductors of cancer's fate
Endocr. Relat. Cancer, December 1, 2008; 15(4): 917 - 929.
[Abstract] [Full Text] [PDF]


Home page
J Med MicrobiolHome page
L. T. Nguyen, T. Uchida, K. Murakami, T. Fujioka, and M. Moriyama
Helicobacter pylori virulence and the diversity of gastric cancer in Asia
J. Med. Microbiol., December 1, 2008; 57(12): 1445 - 1453.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. Biol.Home page
T. J. Phesse, L. Parry, K. R. Reed, K. B. Ewan, T. C. Dale, O. J. Sansom, and A. R. Clarke
Deficiency of Mbd2 Attenuates Wnt Signaling
Mol. Cell. Biol., October 1, 2008; 28(19): 6094 - 6103.
[Abstract] [Full Text] [PDF]


Home page
CarcinogenesisHome page
W. Gao, Y. Kondo, L. Shen, Y. Shimizu, T. Sano, K. Yamao, A. Natsume, Y. Goto, M. Ito, H. Murakami, et al.
Variable DNA methylation patterns associated with progression of disease in hepatocellular carcinomas
Carcinogenesis, October 1, 2008; 29(10): 1901 - 1910.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
T. Shimokawa, U. Tostar, M. Lauth, R. Palaniswamy, M. Kasper, R. Toftgard, and P. G. Zaphiropoulos
Novel Human Glioma-associated Oncogene 1 (GLI1) Splice Variants Reveal Distinct Mechanisms in the Terminal Transduction of the Hedgehog Signal
J. Biol. Chem., May 23, 2008; 283(21): 14345 - 14354.
[Abstract] [Full Text] [PDF]


Home page
DevelopmentHome page
H. Zhao, K. Tanegashima, H. Ro, and I. B. Dawid
Lrig3 regulates neural crest formation in Xenopus by modulating Fgf and Wnt signaling pathways
Development, April 1, 2008; 135(7): 1283 - 1293.
[Abstract] [Full Text] [PDF]


Home page
GeneticsHome page
U. Yazdani, Z. Huang, and J. R. Terman
The Glucose Transporter (GLUT4) Enhancer Factor Is Required for Normal Wing Positioning in Drosophila
Genetics, February 1, 2008; 178(2): 919 - 929.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
K. Lim, C. Han, L. Xu, K. Isse, A. J. Demetris, and T. Wu
Cyclooxygenase-2 Derived Prostaglandin E2 Activates -Catenin in Human Cholangiocarcinoma Cells: Evidence for Inhibition of These Signaling Pathways by {omega}3 Polyunsaturated Fatty Acids
Cancer Res., January 15, 2008; 68(2): 553 - 560.
[Abstract] [Full Text] [PDF]




© The Company of Biologists Ltd 2007