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First published online February 21, 2007
doi: 10.1242/10.1242/jcs.000786

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T-cell-receptor-dependent actin regulatory mechanisms

Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia and University of Pennsylvania School of Medicine, 816D Abramson Research Center, 3615 Civic Center Blvd., Philadelphia, PA 19104, USA

^* Author for correspondence (e-mail: jburkhar{at}mail.med.upenn.edu)

Accepted 2 January 2007

Following stimulation, T cells undergo marked changes in actin architecture that are required for productive immune responses. T-cell-receptor-dependent reorganization of the actin cytoskeleton is necessary for the formation of the immunological synapse at the T-cell–antigen-presenting-cell contact site and the distal pole complex at the opposite face of the T cell. Convergence of specific signaling molecules within these two plasma membrane domains facilitates downstream signaling events leading to full T-cell activation. Recent studies have identified many of the relevant actin-regulatory proteins, and significant progress has been made in our understanding of how these proteins choreograph molecular movements associated with T-cell activation. Proteins such as WASp, WAVE2, HS1 and cofilin direct the formation of a cortical actin scaffold at the immune synapse, while actin-binding proteins such as ezrin and moesin direct binding of signaling molecules to actin filaments within the distal pole complex.

Key words: Actin, T cells, Lymphocyte, WASp, WAVE, HS1, Cofilin, Ezrin, Moesin, Immune synapse, Distal pole complex

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