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First published online May 20, 2008
doi: 10.1242/10.1242/jcs.018036

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Integrin-dependent phagocytosis – spreading from microadhesion to new concepts

Centre for Molecular Microbiology and Infection and Division of Cell and Molecular Biology, Imperial College London, Flowers Building, Armstrong Road, London, SW7 2AZ, UK

^* Author for correspondence (e-mail: e.caron{at}imperial.ac.uk)

Accepted 10 April 2008

By linking actin dynamics to extracellular components, integrins are involved in a wide range of cellular processes that are associated with or require cytoskeletal remodelling and cell-shape changes. One such function is integrin-dependent phagocytosis, a process that several integrins are capable of mediating and that allows the binding and clearance of particles. Integrin-dependent phagocytosis is involved in a wide range of physiological processes, from the clearance of microorganisms and apoptotic-cell removal to extracellular-matrix remodelling. Integrin signalling is also exploited by microbial pathogens for entry into host cells. Far from being a particular property of specific integrins and specialised cells, integrin-dependent uptake is emerging as a general, intrinsic ability of most integrins that is associated with their capacity to signal to the actin cytoskeleton. Integrin-mediated phagocytosis can therefore be used as a robust model in which to study integrin regulation and signalling.

Key words: Integrin, Adhesion, Phagocytosis, Microbial pathogens, Apoptotic cells

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